{"id":"https://openalex.org/W2396825804","doi":"https://doi.org/10.1042/bj2670221","title":"Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 \u03b1-ethinyloestradiol. Relative activities of rat and human liver enzymes","display_name":"Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 \u03b1-ethinyloestradiol. Relative activities of rat and human liver enzymes","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W2396825804","doi":"https://doi.org/10.1042/bj2670221","mag":"2396825804","pmid":"https://pubmed.ncbi.nlm.nih.gov/2327982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131267"},"language":"en","primary_location":{"id":"doi:10.1042/bj2670221","doi":"https://doi.org/10.1042/bj2670221","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2670221","pdf_url":"https://portlandpress.com/biochemj/article-pdf/267/1/221/599589/bj2670221.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/267/1/221/599589/bj2670221.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111734586","display_name":"Simon E. Ball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S E Ball","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.S.A","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084169599","display_name":"Lesley M. Forrester","orcid":"https://orcid.org/0000-0002-9717-8299","observed_orcids":["https://orcid.org/0000-0002-9717-8299"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L M Forrester","raw_affiliation_strings":["ICRF Laboratories of Molecular Pharmacology and Drug Metabolism, Department of Biochemistry, University of Edinburgh, Edinburgh EH8 9XD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICRF Laboratories of Molecular Pharmacology and Drug Metabolism, Department of Biochemistry, University of Edinburgh, Edinburgh EH8 9XD, U.K","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087375405","display_name":"C. Roland Wolf","orcid":"https://orcid.org/0000-0002-6969-0113","observed_orcids":["https://orcid.org/0000-0002-6969-0113"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C R Wolf","raw_affiliation_strings":["ICRF Laboratories of Molecular Pharmacology and Drug Metabolism, Department of Biochemistry, University of Edinburgh, Edinburgh EH8 9XD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICRF Laboratories of Molecular Pharmacology and Drug Metabolism, Department of Biochemistry, University of Edinburgh, Edinburgh EH8 9XD, U.K","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042249868","display_name":"David J. Back","orcid":"https://orcid.org/0000-0002-7381-4799","observed_orcids":["https://orcid.org/0000-0002-7381-4799"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D J Back","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.S.A","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2628,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.97392152,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"267","issue":"1","first_page":"221","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p-450-isoenzymes","display_name":"cytochrome P-450 isoenzymes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.6909999847412109},{"id":"https://openalex.org/keywords/antibody-inhibition-of-enzyme-activity","display_name":"antibody inhibition of enzyme activity","score":0.5509999990463257},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.8283436298370361},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.7717556357383728},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.7180598974227905},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6840105056762695},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.636267900466919},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.632466197013855},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6054617166519165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5569778084754944},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.5191839933395386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4914606809616089},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.44770434498786926}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004997","descriptor_name":"Ethinyl Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/bj2670221","doi":"https://doi.org/10.1042/bj2670221","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2670221","pdf_url":"https://portlandpress.com/biochemj/article-pdf/267/1/221/599589/bj2670221.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4425375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1131267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:2327982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2327982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Comparative Study"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/a09848e4-1f39-479d-a46c-49cd9b8d0f9d","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/a09848e4-1f39-479d-a46c-49cd9b8d0f9d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ball, S E, Forrester, L M, Wolf, C R & Back, D J 1990, 'Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17\u03b1-ethinyloestradiol : relative activities of rat and human liver enzymes', Biochemical Journal, vol. 267, no. 1, pp. 221-226. https://doi.org/10.1042/bj2670221","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1042/bj2670221","doi":"https://doi.org/10.1042/bj2670221","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2670221","pdf_url":"https://portlandpress.com/biochemj/article-pdf/267/1/221/599589/bj2670221.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2396825804.pdf","grobid_xml":"https://content.openalex.org/works/W2396825804.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W166341590","https://openalex.org/W181857568","https://openalex.org/W208822947","https://openalex.org/W1500814526","https://openalex.org/W1520965071","https://openalex.org/W1608334798","https://openalex.org/W1614919593","https://openalex.org/W1775749144","https://openalex.org/W1951469402","https://openalex.org/W1974834753","https://openalex.org/W1997443051","https://openalex.org/W2018289835","https://openalex.org/W2022628424","https://openalex.org/W2027458234","https://openalex.org/W2046847066","https://openalex.org/W2046860844","https://openalex.org/W2047389924","https://openalex.org/W2059472777","https://openalex.org/W2063128948","https://openalex.org/W2065670181","https://openalex.org/W2071913214","https://openalex.org/W2075200935","https://openalex.org/W2083548377","https://openalex.org/W2092624958","https://openalex.org/W2101108802","https://openalex.org/W2105416058","https://openalex.org/W2105876917","https://openalex.org/W2108572185","https://openalex.org/W2136358824","https://openalex.org/W2138822530","https://openalex.org/W2151201559","https://openalex.org/W2164646340","https://openalex.org/W2340484157","https://openalex.org/W6600540670"],"related_works":["https://openalex.org/W1992900791","https://openalex.org/W1989397106","https://openalex.org/W2035382226","https://openalex.org/W2380196317","https://openalex.org/W2083675642","https://openalex.org/W1996048503","https://openalex.org/W4388330084","https://openalex.org/W2119955031","https://openalex.org/W2022613565","https://openalex.org/W1994056607"],"abstract_inverted_index":{"The":[0],"metabolism":[1,170],"of":[2,46,74,81,97,118,145,179,200,221,227,229],"oestradiol":[3,66,169],"and":[4,56,133,158,182,217],"17":[5,59,146],"alpha-ethinyloestradiol":[6,147],"to":[7,88,103,111,203],"their":[8,16],"2-hydroxy":[9],"derivatives":[10],"is":[11,150],"an":[12],"important":[13],"determinant":[14],"in":[15,34,100,115,148,168,197,210,215,232],"biological":[17],"effects.":[18],"In":[19,86,162],"this":[20],"work,":[21],"we":[22],"have":[23],"investigated":[24],"which":[25,61,90],"rat":[26,47,104,201],"or":[27],"human":[28,119],"cytochrome":[29,48,106],"P-450":[30,107],"isoenzymes":[31,108],"are":[32,92,171,207],"involved":[33,167,214],"catalysing":[35],"these":[36,98,113,205,230],"reactions.":[37],"Oestradiol":[38],"2-hydroxylation":[39,135,144],"was":[40,76],"catalysed":[41,151],"by":[42,79,130,152],"a":[43,68,116,189,219],"wide":[44],"variety":[45,220],"P-450s":[49,202],"from":[50,65,71,154,172],"gene":[51,84,160,175,184],"families":[52,185],"P450IA,":[53],"P450IIB,":[54],"P450IIC":[55,83,181],"P450IIIA.":[57],"Interestingly,":[58],"alpha-ethinyloestradiol,":[60],"only":[62],"differs":[63],"structurally":[64],"at":[67],"position":[69],"distant":[70],"the":[72,82,95,127,131,134,155,164,173,180,195,198,211,225],"site":[73],"oxidation,":[75],"metabolized":[77],"predominantly":[78],"members":[80,178],"subfamily.":[85],"order":[87],"establish":[89],"enzymes":[91,213],"responsible":[93],"for":[94],"oxidation":[96],"substrates":[99,206],"man,":[101,216],"antibodies":[102,132],"liver":[105,120],"were":[109,137],"used":[110],"inhibit":[112],"reactions":[114],"panel":[117],"microsomal":[121],"fractions.":[122],"Also,":[123],"possible":[124],"correlations":[125],"between":[126],"proteins":[128,166],"recognized":[129],"rate":[136,226],"determined.":[138],"These":[139,191],"experiments":[140],"provide":[141],"evidence":[142],"that":[143,194,218],"man":[149],"cytochromes":[153],"P450IIC,":[156],"P450IIE":[157,183],"P450IIIA":[159],"families.":[161],"contrast,":[163],"major":[165],"P450IA":[174],"family,":[176],"although":[177],"may":[186],"also":[187,208],"play":[188],"role.":[190],"data":[192],"demonstrate":[193],"differences":[196],"capacity":[199],"metabolize":[204],"present":[209],"comparable":[212],"factors":[222],"will":[223],"determine":[224],"disposition":[228],"compounds":[231],"man.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}