{"id":"https://openalex.org/W2396782896","doi":null,"title":"Morphological aspects of altered basement membrane metabolism in invasive carcinomas of the breast and the larynx.","display_name":"Morphological aspects of altered basement membrane metabolism in invasive carcinomas of the breast and the larynx.","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2396782896","mag":"2396782896","pmid":"https://pubmed.ncbi.nlm.nih.gov/9858933"},"language":"en","primary_location":{"id":"pmid:9858933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9858933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058718221","display_name":"Michael L. Nerlich","orcid":"https://orcid.org/0000-0001-6562-1017","observed_orcids":["https://orcid.org/0000-0001-6562-1017"]},"institutions":[{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A G Nerlich","raw_affiliation_strings":["Pathologisches Institut, Universit\u00e4t M\u00fcnchen, Germany. Andreas.Nerlich@lrz.uni-muenchen.de","Pathologisches Institut, Universit\u00e4t M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathologisches Institut, Universit\u00e4t M\u00fcnchen, Germany. Andreas.Nerlich@lrz.uni-muenchen.de","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Pathologisches Institut, Universit\u00e4t M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110582762","display_name":"Annette Lebeau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lebeau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112103638","display_name":"Hjalmar G. Hagedorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H G Hagedorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000079750","display_name":"Ulrich Sauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Sauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088588511","display_name":"Schleicher Ed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Schleicher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1285,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.76336499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"5A","first_page":"3515","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.3328000009059906,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.3328000009059906,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.15970000624656677,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.9700000286102295},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6209999918937683},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.890999972820282},{"id":"https://openalex.org/keywords/laminin-1","display_name":"laminin-1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/perlecan","display_name":"perlecan","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/type-vii-collagen","display_name":"type VII collagen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.7861357927322388},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6658322811126709},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6609958410263062},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6432314515113831},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.6006818413734436},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5743064284324646},{"id":"https://openalex.org/C22731427","wikidata":"https://www.wikidata.org/wiki/Q2071346","display_name":"Perlecan","level":4,"score":0.563639760017395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.542058527469635},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.45327579975128174},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.44845080375671387},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.42814281582832336},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.40111517906188965},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3217664957046509},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.2172728180885315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1451529562473297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11958613991737366}],"mesh":[{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9858933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9858933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},{"id":"mag:2396782896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9858933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992814841","https://openalex.org/W111455835","https://openalex.org/W2118468425","https://openalex.org/W2032692583","https://openalex.org/W2065584855","https://openalex.org/W2054032281","https://openalex.org/W2407388602","https://openalex.org/W2385693411","https://openalex.org/W2019215817","https://openalex.org/W2045327046"],"abstract_inverted_index":{"In":[0,123,160,194],"the":[1,6,21,35,59,104,113,118,124,138,145,161,181,197,203,233,252,262,275,298,305,312,324],"present":[2],"study":[3],"we":[4,206],"compared":[5,322],"localization":[7],"of":[8,20,37,45,166,174,183,192,202,211,251,261,302,317],"major":[9,281],"basement":[10],"membrane":[11],"(BM)":[12],"components":[13,141],"and":[14,24,40,74,97,179,217,228,240,268],"their":[15],"mRNAs":[16,263],"between":[17,224],"invasive":[18,114],"carcinomas":[19,26,51,149,307],"breast":[22,50,125,267,306],"(adenocarcinomas)":[23],"larynx":[25,105,269],"(squamous":[27],"cell":[28,235],"carcinomas,":[29,115,126,270],"SCC),":[30],"in":[31,42,103,112,133,144,266,274,283,304],"order":[32],"to":[33,196,232,311,323],"determine":[34],"extent":[36,182],"BM":[38,81,140,154],"production":[39],"deposition":[41,277],"malignant":[43],"tumors":[44,136],"biologically":[46],"different":[47],"behaviour.":[48],"Thus,":[49],"usually":[52],"show":[53,63],"a":[54,64,85,127,171,189,208,247,258],"rapid":[55],"locoregional/systemic":[56],"spread,":[57],"while":[58,143],"laryngeal":[60,75],"SCCs":[61,146],"normally":[62],"more":[65,153,248,313],"locally":[66],"restricted":[67],"growth":[68],"pattern.":[69],"While":[70],"normal":[71],"mammary":[72],"glands":[73],"mucosa":[76],"revealed":[77],"an":[78,163],"intact":[79],"epithelial":[80],"as":[82,100],"evidenced":[83],"by":[84,200],"continuous":[86,108],"linear":[87],"staining":[88,109],"for":[89,213,264],"collagen":[90,101,167,175,214],"IV,":[91,176,215],"laminin-1,":[92],"heparan":[93],"sulfate":[94],"proteoglycan":[95],"(perlecan)":[96],"fibronectin-as":[98],"well":[99,134,147],"VII":[102,168],"mucosa-,":[106],"this":[107],"was":[110,130,222],"lost":[111],"however,":[116,186],"affecting":[117,137],"two":[119],"tumor":[120,226,234,238],"types":[121,227],"differently.":[122],"complete":[128],"loss":[129,165,173],"seen":[131],"even":[132],"differentiated":[135,148,158],"various":[139],"similarly,":[142],"had":[150],"retained":[151],"significantly":[152,230],"material":[155],"than":[156],"poorly":[157],"ones.":[159],"SCCs,":[162],"\"early\"":[164],"contrasted":[169],"with":[170,188,246],"\"later\"":[172],"laminin,":[177],"perlecan":[178,216],"fibronectin":[180],"which":[184],"was,":[185],"associated":[187],"decreasing":[190],"degree":[191],"differentiation.":[193,236],"contrast":[195],"protein":[198],"findings,":[199],"use":[201],"in-situ":[204],"hybridization":[205],"observed":[207],"significant":[209,272],"expression":[210],"mRNA":[212],"fibronectin.":[218],"The":[219],"resulting":[220],"pattern":[221],"comparable":[223],"both":[225],"not":[229],"related":[231],"Both":[237],"cells":[239,242],"stroma":[241,253],"were":[243],"positively":[244],"labelled":[245],"extensive":[249],"labelling":[250],"cells.":[254],"Our":[255],"observations":[256],"indicate":[257],"similar":[259],"upregulation":[260],"BM-components":[265],"but":[271],"differences":[273,282],"BM-protein":[276],"so":[278],"that":[279,297],"either":[280],"presumed":[284],"BM-proteolysis":[285],"or":[286],"further":[287],"translational":[288],"defects":[289],"are":[290],"suggested.":[291],"Furthermore,":[292],"it":[293],"can":[294],"be":[295,309],"speculated":[296],"far":[299],"lesser":[300],"amount":[301],"BM-material":[303],"may":[308],"linked":[310],"aggressive":[314],"metastatic":[315],"spread":[316],"those":[318],"tumors,":[319],"particularly":[320],"when":[321],"SCCs.":[325]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}