{"id":"https://openalex.org/W2396769601","doi":null,"title":"[Involvement of p38 MAPK pathway in GLP-1-induced inhibition of apoptosis in human umbilical vein endothelial cells].","display_name":"[Involvement of p38 MAPK pathway in GLP-1-induced inhibition of apoptosis in human umbilical vein endothelial cells].","publication_year":2012,"publication_date":"2012-08-25","ids":{"openalex":"https://openalex.org/W2396769601","mag":"2396769601","pmid":"https://pubmed.ncbi.nlm.nih.gov/22907305"},"language":"zh","primary_location":{"id":"pmid:22907305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22907305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006581537","display_name":"Hua Xi Xu","orcid":"https://orcid.org/0000-0001-5607-7742","observed_orcids":["https://orcid.org/0000-0001-5607-7742"]},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Xu","raw_affiliation_strings":["Department of Pathophysiology, Ningxia Medical University, Yinchuan 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Ningxia Medical University, Yinchuan 750004, China","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440684","display_name":"Hailong Li","orcid":"https://orcid.org/0000-0003-3669-8052","observed_orcids":["https://orcid.org/0000-0003-3669-8052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai-Long Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060751084","display_name":"Zi-Yong Niu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zi-Yong Niu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103161299","display_name":"Guizhong Li","orcid":"https://orcid.org/0000-0001-7684-0119","observed_orcids":["https://orcid.org/0000-0001-7684-0119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gui-Zhong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053056041","display_name":"Jun Cao","orcid":"https://orcid.org/0000-0002-6894-4011","observed_orcids":["https://orcid.org/0000-0002-6894-4011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047374071","display_name":"Yideng Jiang","orcid":"https://orcid.org/0000-0001-6339-3970","observed_orcids":["https://orcid.org/0000-0001-6339-3970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Deng Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.105,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44542225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64","issue":"4","first_page":"444","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.11420000344514847,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.11249999701976776,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/p38-mapk-pathway","display_name":"p38 MAPK pathway","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.9480000138282776},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/endothelial-protection","display_name":"endothelial protection","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.898961067199707},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7996445894241333},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.7937666177749634},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.753067672252655},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6785584688186646},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49570953845977783},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.47650256752967834},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46289271116256714},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.44919583201408386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44617751240730286},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.42338818311691284},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4148891270160675},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38933905959129333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3560289144515991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34269246459007263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20269381999969482},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.09495452046394348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22907305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22907305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:2396769601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22907305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2517040337","https://openalex.org/W2755428392","https://openalex.org/W2393766216","https://openalex.org/W2498655213","https://openalex.org/W2526156861","https://openalex.org/W7020009214","https://openalex.org/W1979835257","https://openalex.org/W2351945278","https://openalex.org/W2039417521","https://openalex.org/W2772877608"],"abstract_inverted_index":{"The":[0,78],"aim":[1],"of":[2,11,18,53,99,114],"the":[3,9,26,54,112],"present":[4],"study":[5],"was":[6,44,73],"to":[7,39,46],"investigate":[8],"effect":[10,133],"glucagon-like":[12],"peptide-1":[13],"(GLP-1)":[14],"on":[15],"palmitate-induced":[16,97],"apoptosis":[17],"human":[19],"umbilical":[20],"vein":[21],"endothelial":[22],"cells":[23],"(HUVECs)":[24],"and":[25,34,58,91,102,131],"underlying":[27],"mechanism.":[28],"HUVECs":[29,83,128],"were":[30,61],"cultured":[31],"in":[32,105,121],"vitro,":[33],"then":[35],"treated":[36],"by":[37,75,119],"palmitate":[38,120],"induce":[40],"apoptosis.":[41],"Meanwhile,":[42],"GLP-1":[43,87,94,110,126],"added":[45],"explore":[47],"its":[48],"effect.":[49],"After":[50],"24":[51],"h":[52],"treatments,":[55],"Caspase-3":[56,89,100],"activity":[57,90,101],"DNA":[59,92,103],"fragmentation":[60,104],"measured":[62],"using":[63],"ELISA":[64],"kits.":[65],"Phospho-p38":[66],"mitogen-activated":[67],"protein":[68],"kinase":[69],"(p-p38":[70],"MAPK)":[71],"expression":[72,117],"detected":[74],"Western":[76],"blot.":[77],"results":[79,124],"showed":[80],"that":[81],"incubating":[82],"with":[84],"0.125":[85],"mmol/L":[86],"increased":[88],"fragmentation.":[93],"significantly":[95],"inhibited":[96,111],"increases":[98],"a":[106],"concentration-dependent":[107],"manner.":[108],"Moreover,":[109],"up-regulation":[113],"p-p38":[115],"MAPK":[116,140],"induced":[118],"HUVECs.":[122],"These":[123],"suggest":[125],"protects":[127],"against":[129],"lipo-apoptosis,":[130],"this":[132],"may":[134],"be":[135],"mediated":[136],"through":[137],"inhibiting":[138],"p38":[139],"pathway.":[141]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
