{"id":"https://openalex.org/W2396729574","doi":"https://doi.org/10.1093/ajh/6.11.944","title":"Effect of Long-Term Administration of 1,25 (OH)2 Vitamin D3 on Blood Pressure and Resistance Artery Contractility in the Spontaneously Hypertensive Rat","display_name":"Effect of Long-Term Administration of 1,25 (OH)2 Vitamin D3 on Blood Pressure and Resistance Artery Contractility in the Spontaneously Hypertensive Rat","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2396729574","doi":"https://doi.org/10.1093/ajh/6.11.944","mag":"2396729574","pmid":"https://pubmed.ncbi.nlm.nih.gov/8305169"},"language":"en","primary_location":{"id":"doi:10.1093/ajh/6.11.944","doi":"https://doi.org/10.1093/ajh/6.11.944","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/6.11.944","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112091674","display_name":"Richard D. Bukoski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard D. Bukoski","raw_affiliation_strings":["Hypertension Laboratory, University of Texas Medical Branch, Galveston Island 77550","Hypertension and Vascular Research Laboratories, University of Texas Medical Branch, Galveston Island, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension Laboratory, University of Texas Medical Branch, Galveston Island 77550","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Hypertension and Vascular Research Laboratories, University of Texas Medical Branch, Galveston Island, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363204","display_name":"Junyi Li","orcid":"https://orcid.org/0000-0001-8435-2262","observed_orcids":["https://orcid.org/0000-0001-8435-2262"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junyi Li","raw_affiliation_strings":["Hypertension and Vascular Research Laboratories, University of Texas Medical Branch, Galveston Island, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Vascular Research Laboratories, University of Texas Medical Branch, Galveston Island, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jie Bo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Bo","raw_affiliation_strings":["Hypertension and Vascular Research Laboratories, University of Texas Medical Branch, Galveston Island, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Vascular Research Laboratories, University of Texas Medical Branch, Galveston Island, Texas","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112091674"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.5419,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.70787328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"6","issue":"11_Pt_1","first_page":"944","last_page":"950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hereditary-hypertension","display_name":"genetic hypertension","score":0.625},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9779999852180481},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mesenteric-resistance-arteries","display_name":"mesenteric resistance arteries","score":0.871999979019165},{"id":"https://openalex.org/keywords/vascular-contractility","display_name":"vascular contractility","score":0.9259999990463257},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7490000128746033},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acetylcholine-induced-relaxation","display_name":"acetylcholine-induced relaxation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/serum-ionized-calcium","display_name":"serum ionized calcium","score":0.8650000095367432},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8757089972496033},{"id":"https://openalex.org/C2779941686","wikidata":"https://www.wikidata.org/wiki/Q6947930","display_name":"Myograph","level":3,"score":0.7362385988235474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7356473803520203},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7129958271980286},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.706646740436554},{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.5798316597938538},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5684487819671631},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5669586062431335},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4911081790924072},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.4633851945400238},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.4554769992828369},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.3867112100124359}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajh/6.11.944","doi":"https://doi.org/10.1093/ajh/6.11.944","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/6.11.944","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:8305169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8305169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G366079477","display_name":"CALCIOTROPIC HORMONE ACTION ON ARTERIAL MUSCLE","funder_award_id":"R29HL041816","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096693851","https://openalex.org/W2415286928","https://openalex.org/W2404866822","https://openalex.org/W2121792192","https://openalex.org/W2365287040","https://openalex.org/W2145839234","https://openalex.org/W7120381946","https://openalex.org/W6999142008","https://openalex.org/W2396355358","https://openalex.org/W2096434218"],"abstract_inverted_index":{"The":[0,196],"effect":[1],"of":[2,6,33,40,49,91,163,200,270],"long-term":[3],"daily":[4,46],"injection":[5,269],"1,25":[7,52,110,173,189,219,253,271],"(OH)2":[8,53,111,174,190,220,254,272],"vitamin":[9,54,112,175,191,221,255,273],"D3":[10,55,113,192,222,256,274],"on":[11],"blood":[12,69,134,293],"pressure":[13,70,99,135,294],"and":[14,67,83,107,117,153,170,205,216],"contractile":[15,92],"force":[16],"generation":[17,278],"by":[18,279],"subsequently":[19],"isolated":[20,88],"mesenteric":[21,84],"resistance":[22,85,201,280],"arteries":[23,86,202,281],"was":[24,78,140,157,180,208,237,245,260],"examined":[25],"using":[26,94],"the":[27,103,121,126,144,149,161,184,248,289,296],"spontaneously":[28],"hypertensive":[29],"rat":[30],"(SHR)":[31],"model":[32],"genetic":[34],"hypertension.":[35],"Beginning":[36],"at":[37,56],"6":[38,152],"weeks":[39,116,130],"age,":[41],"male":[42],"SHR":[43],"were":[44,71,87,233],"given":[45],"intraperitoneal":[47],"injections":[48],"vehicle,":[50],"or":[51,59],"20,":[57],"30,":[58],"40":[60,108,122,171,217,251],"ng/100":[61],"g":[62],"body":[63],"weight.":[64],"Body":[65],"weight":[66,164],"systolic":[68],"determined":[72],"weekly.":[73],"After":[74],"9":[75,154],"weeks,":[76,155],"serum":[77],"prepared":[79],"for":[80,89],"electrolyte":[81],"analysis":[82],"assessment":[90],"function":[93],"a":[95,158,285],"wire":[96],"myograph.":[97],"Blood":[98],"became":[100],"elevated":[101,119,182,210],"in":[102,120,160,166,183,211,227,239,247,288,292,295],"rats":[104,167,212],"receiving":[105,168,250],"20":[106],"ng":[109,123,172,218,252],"after":[114],"5":[115],"remained":[118],"group":[124,249],"during":[125,148],"sixth":[127],"week.":[128],"Between":[129],"six":[131],"to":[132,137,203,230],"nine,":[133],"continued":[136],"rise":[138,291],"but":[139,224,244,282],"not":[141],"different":[142],"among":[143],"groups.":[145],"In":[146],"addition,":[147],"period":[150],"between":[151],"there":[156],"decline":[159],"rate":[162],"gain":[165],"30":[169,215],"D3.":[176],"Serum":[177],"ionized":[178],"Ca2+":[179],"significantly":[181,209],"three":[185],"groups":[186],"treated":[187],"with":[188,194,242,262],"compared":[193],"control.":[195],"active":[197,276],"stress":[198,277],"response":[199],"norepinephrine":[204],"arginine":[206,263],"vasopressin":[207],"that":[213,267],"received":[214],",":[223],"no":[225],"differences":[226],"apparent":[228],"sensitivity":[229],"these":[231],"agonists":[232],"detected.":[234],"Acetylcholine-induced":[235],"relaxation":[236],"unaltered":[238],"vessels":[240],"pre-contracted":[241],"norepinephrine,":[243],"enhanced":[246],"when":[257],"pre-relaxation":[258],"tone":[259],"induced":[261],"vasopressin.":[264],"We":[265],"conclude":[266],"chronic":[268],"increases":[275],"has":[283],"only":[284],"slight":[286],"increase":[287],"normal":[290],"growing":[297],"SHR.":[298],"Am":[299],"J":[300],"Hypertens":[301],"1993;6:":[302],"944-950":[303]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
