{"id":"https://openalex.org/W2396715517","doi":"https://doi.org/10.3390/polym8050188","title":"Repair Effect of Seaweed Polysaccharides with Different Contents of Sulfate Group and Molecular Weights on Damaged HK-2 Cells","display_name":"Repair Effect of Seaweed Polysaccharides with Different Contents of Sulfate Group and Molecular Weights on Damaged HK-2 Cells","publication_year":2016,"publication_date":"2016-05-19","ids":{"openalex":"https://openalex.org/W2396715517","doi":"https://doi.org/10.3390/polym8050188","mag":"2396715517","pmid":"https://pubmed.ncbi.nlm.nih.gov/30979293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6431945"},"language":"en","primary_location":{"id":"doi:10.3390/polym8050188","doi":"https://doi.org/10.3390/polym8050188","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym8050188","pdf_url":"https://www.mdpi.com/2073-4360/8/5/188/pdf?version=1463638864","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4360/8/5/188/pdf?version=1463638864","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051091708","display_name":"Poonam Bhadja","orcid":"https://orcid.org/0000-0003-2060-4189","observed_orcids":["https://orcid.org/0000-0003-2060-4189"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Poonam Bhadja","raw_affiliation_strings":["Department of Chemistry, Jinan University, Guangzhou 510632, China","Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062931068","display_name":"Cai-Yan Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai-Yan Tan","raw_affiliation_strings":["Department of Chemistry, Jinan University, Guangzhou 510632, China","Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053951868","display_name":"Jian\u2010Ming Ouyang","orcid":"https://orcid.org/0000-0001-8075-3915","observed_orcids":["https://orcid.org/0000-0001-8075-3915"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Ming Ouyang","raw_affiliation_strings":["Department of Chemistry, Jinan University, Guangzhou 510632, China","Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kai Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Yu","raw_affiliation_strings":["Department of Chemistry, Jinan University, Guangzhou 510632, China","Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053951868"],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":9.1166,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.97640798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"188","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10643","display_name":"Marine and coastal plant biology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1910","display_name":"Oceanography"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seaweed-polysaccharides","display_name":"seaweed polysaccharides","score":0.9990000128746033},{"id":"https://openalex.org/keywords/low-molecular-weight-polysaccharides","display_name":"low molecular weight polysaccharides","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sulfate-content","display_name":"sulfate content","score":0.7329999804496765},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/renal-repair","display_name":"renal repair","score":0.656000018119812},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7730000019073486},{"id":"https://openalex.org/keywords/saccharina-japonica","display_name":"Laminaria japonica","score":0.7379999756813049},{"id":"https://openalex.org/keywords/porphyra-yezoensis","display_name":"Porphyra yezoensis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gracilariopsis-lemaneiformis","display_name":"Gracilaria lemaneiformis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sargassum-fusiforme","display_name":"Sargassum fusiforme","score":1.0},{"id":"https://openalex.org/keywords/undaria-pinnatifida","display_name":"Undaria pinnatifida","score":1.0},{"id":"https://openalex.org/keywords/hydrogen-peroxide-decomposition","display_name":"hydrogen peroxide decomposition","score":0.6620000004768372},{"id":"https://openalex.org/keywords/kidney-stone-prevention","display_name":"kidney stone prevention","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.7681441307067871},{"id":"https://openalex.org/C2778343803","wikidata":"https://www.wikidata.org/wiki/Q172290","display_name":"Sulfate","level":2,"score":0.6323466897010803},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.5899302363395691},{"id":"https://openalex.org/C559758991","wikidata":"https://www.wikidata.org/wiki/Q37868","display_name":"Algae","level":2,"score":0.5658060312271118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47618189454078674},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.43890708684921265},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3068050444126129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.263241171836853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2500072717666626},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20802080631256104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06832614541053772}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/polym8050188","doi":"https://doi.org/10.3390/polym8050188","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym8050188","pdf_url":"https://www.mdpi.com/2073-4360/8/5/188/pdf?version=1463638864","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5429748","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6431945","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6431945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6431945","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers (Basel)","raw_type":"Text"},{"id":"pmid:30979293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30979293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:07b341cf7c3747cbb1b41c29986df9d3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/07b341cf7c3747cbb1b41c29986df9d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Polymers, Vol 8, Iss 5, p 188 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/polym8050188","doi":"https://doi.org/10.3390/polym8050188","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym8050188","pdf_url":"https://www.mdpi.com/2073-4360/8/5/188/pdf?version=1463638864","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.8899999856948853,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4861652770","display_name":null,"funder_award_id":"21371077","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2396715517.pdf","grobid_xml":"https://content.openalex.org/works/W2396715517.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W317714569","https://openalex.org/W833729729","https://openalex.org/W1576217319","https://openalex.org/W1582534203","https://openalex.org/W1966623843","https://openalex.org/W1973884378","https://openalex.org/W1977077814","https://openalex.org/W1978211370","https://openalex.org/W1980732776","https://openalex.org/W1982609685","https://openalex.org/W1982686225","https://openalex.org/W1983939939","https://openalex.org/W1984587475","https://openalex.org/W1988987416","https://openalex.org/W1993612702","https://openalex.org/W1995539445","https://openalex.org/W2000834839","https://openalex.org/W2009110442","https://openalex.org/W2011740016","https://openalex.org/W2016746548","https://openalex.org/W2021667666","https://openalex.org/W2029224019","https://openalex.org/W2030074580","https://openalex.org/W2036698624","https://openalex.org/W2037833392","https://openalex.org/W2037920204","https://openalex.org/W2038385687","https://openalex.org/W2039765829","https://openalex.org/W2047671425","https://openalex.org/W2052165270","https://openalex.org/W2057728040","https://openalex.org/W2073515589","https://openalex.org/W2077724427","https://openalex.org/W2078326461","https://openalex.org/W2078477215","https://openalex.org/W2090589673","https://openalex.org/W2090606649","https://openalex.org/W2103481916","https://openalex.org/W2218291607","https://openalex.org/W2279858157"],"related_works":["https://openalex.org/W2736002691","https://openalex.org/W2887381918","https://openalex.org/W2789439207","https://openalex.org/W2951711598","https://openalex.org/W2955786841","https://openalex.org/W2901555020","https://openalex.org/W3123237905","https://openalex.org/W3000810219","https://openalex.org/W3135734556","https://openalex.org/W2990806285"],"abstract_inverted_index":{"The":[0,70,115,134],"structure\u2013activity":[1],"relationships":[2],"and":[3,45,85,88,110,128,150,203],"repair":[4,116,155,172,181],"mechanism":[5],"of":[6,56,75,107,113,118,165,200],"six":[7,77],"low-molecular-weight":[8,176],"seaweed":[9],"polysaccharides":[10,119,178],"(SPSs)":[11],"on":[12,157,183],"oxalate-induced":[13,158],"damaged":[14,159,184],"human":[15],"kidney":[16,201],"proximal":[17],"tubular":[18],"epithelial":[19],"cells":[20,186],"(HK-2)":[21],"were":[22],"investigated.":[23],"These":[24,50],"SPSs":[25,51,78,139],"included":[26],"Laminaria":[27],"japonica":[28],"polysaccharide,":[29,33,37,41,44],"degraded":[30,34,38,46,177],"Porphyra":[31],"yezoensis":[32],"Gracilaria":[35],"lemaneiformis":[36],"Sargassum":[39],"fusiforme":[40],"Eucheuma":[42],"gelatinae":[43],"Undaria":[47],"pinnatifida":[48],"polysaccharide.":[49],"have":[52],"a":[53,154],"narrow":[54],"difference":[55,101],"molecular":[57],"weight":[58],"(from":[59],"1968":[60],"to":[61,95],"4020":[62],"Da)":[63],"after":[64],"degradation":[65],"by":[66,125,131],"controlling":[67],"H2O2":[68],"concentration.":[69],"sulfate":[71],"group":[72],"(\u2013SO3H)":[73],"content":[74,164],"the":[76,89,105,163,175,198],"was":[79,102,120,168],"21.7%,":[80],"17.9%,":[81],"13.3%,":[82],"8.2%,":[83],"7.0%,":[84],"5.5%,":[86],"respectively,":[87],"\u2013COOH":[90,111],"contents":[91,106],"varied":[92],"between":[93],"1.0%":[94],"1.7%.":[96],"After":[97],"degradation,":[98],"no":[99],"significant":[100],"observed":[103],"in":[104,147],"characteristic":[108],"\u2013SO3H":[109,167],"groups":[112],"polysaccharides.":[114],"effect":[117,156],"determined":[121],"using":[122],"cell-viability":[123],"test":[124,130],"CCK-8":[126],"assay":[127],"cell-morphology":[129],"hematoxylin-eosin":[132],"staining.":[133],"results":[135,192],"revealed":[136],"that":[137],"these":[138],"within":[140],"0.1\u2013100":[141],"\u03bcg/mL":[142],"did":[143],"not":[144],"express":[145],"cytotoxicity":[146],"HK-2":[148,160,185],"cells,":[149],"each":[151],"polysaccharide":[152,166,208],"had":[153],"cells.":[161],"Simultaneously,":[162],"positively":[169],"correlated":[170],"with":[171],"ability.":[173],"Furthermore,":[174],"showed":[179],"better":[180],"activity":[182],"than":[187],"their":[188],"undegraded":[189],"counterpart.":[190],"Our":[191],"can":[193],"provide":[194],"reference":[195],"for":[196,204],"inhibiting":[197],"formation":[199],"stones":[202],"developing":[205],"original":[206],"anti-stone":[207],"drugs.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}