{"id":"https://openalex.org/W2396688258","doi":null,"title":"Pharmacokinetics and bioavailability of metoclopramide nasal spray versus metoclopramide intravenous in healthy volunteers and cancer patients.","display_name":"Pharmacokinetics and bioavailability of metoclopramide nasal spray versus metoclopramide intravenous in healthy volunteers and cancer patients.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2396688258","mag":"2396688258","pmid":"https://pubmed.ncbi.nlm.nih.gov/8240464"},"language":"en","primary_location":{"id":"pmid:8240464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8240464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000642598","display_name":"Franco Scaglione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Scaglione","raw_affiliation_strings":["Department of Pharmacology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056895830","display_name":"Alberto Scanni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Scanni","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069497601","display_name":"Maurizio Tomirotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Tomirotti","raw_affiliation_strings":["Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico;","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057957704","display_name":"Mariastella Dimaiuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Dimaiuta","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Ferrari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Ferrari","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107639580","display_name":"FRANCO FRASCHINI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Fraschini","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1409,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79684888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"43","issue":"9","first_page":"986","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":1.0},{"id":"https://openalex.org/keywords/nasal-spray","display_name":"nasal spray","score":0.8920000195503235},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.996999979019165},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.593999981880188},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea-and-vomiting","display_name":"chemotherapy-induced nausea and vomiting","score":0.8360000252723694},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cmax","display_name":"Cmax","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2778479196","wikidata":"https://www.wikidata.org/wiki/Q421095","display_name":"Metoclopramide","level":3,"score":0.9498916268348694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7409706711769104},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6534010171890259},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6451231837272644},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6120148301124573},{"id":"https://openalex.org/C2780973058","wikidata":"https://www.wikidata.org/wiki/Q1755275","display_name":"Nasal spray","level":3,"score":0.5952285528182983},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5852245092391968},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5185238122940063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34527063369750977},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.3372519314289093},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.08841177821159363}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008787","descriptor_name":"Metoclopramide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008787","descriptor_name":"Metoclopramide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8240464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8240464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},{"id":"mag:2396688258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8240464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023540817","https://openalex.org/W2472413903","https://openalex.org/W2604576864","https://openalex.org/W7030259441","https://openalex.org/W2004729922","https://openalex.org/W1482441247","https://openalex.org/W2163952486","https://openalex.org/W2073343441","https://openalex.org/W1998896195","https://openalex.org/W2036742150"],"abstract_inverted_index":{"The":[0,44,109,125],"kinetics":[1,214],"and":[2,62,87,96,143,146,153,199,236],"bioavailability":[3],"of":[4,8,99,115,156,174,209,251],"a":[5,32,73,246],"new":[6],"formulation":[7],"metoclopramide":[9,53,63],"(CAS":[10],"364-62-5)":[11],"nasal":[12],"spray":[13,184],"(MTC":[14,28],"NS)":[15],"were":[16,82,103,218],"assessed":[17],"in":[18,105,171,201,219,255],"two":[19,68],"separate":[20],"studies":[21],"versus":[22],"the":[23,131,162,172,182,207,226,256],"same":[24],"drug":[25],"administered":[26],"intravenously":[27],"IV)":[29],"according":[30],"to":[31,119,130,190],"balanced-block":[33],"design":[34,127],"where":[35],"each":[36,51],"study":[37,46,111],"subject":[38,178],"served":[39],"as":[40],"his":[41],"own":[42],"control.":[43],"first":[45],"involved":[47,112],"10":[48,113],"healthy":[49,159,234],"subjects,":[50],"receiving":[52],"NS":[54,241],"20":[55,65],"mg":[56,66],"(one":[57],"10-mg":[58],"puff":[59],"per":[60],"nostril)":[61],"IV":[64],"on":[67],"trial":[69,163],"days":[70],"separated":[71],"by":[72,107,197],"7-day":[74],"washout":[75],"period.":[76],"On":[77],"both":[78],"occasions,":[79],"blood":[80,136],"samples":[81],"obtained":[83],"at":[84,88,139,148],"time":[85],"0":[86],"20,":[89,141],"40,":[90],"60,":[91],"120,":[92],"150,":[93],"210,":[94],"280":[95],"360":[97],"min":[98,145],"dosing.":[100,157],"Metoclopramide":[101,213],"concentrations":[102],"assayed":[104],"plasma":[106],"HPLC.":[108],"second":[110],"patients":[114],"oncologic":[116],"domain,":[117],"scheduled":[118],"receive":[120],"mildly":[121],"emetic":[122],"chemotherapy":[123],"regimes.":[124],"experimental":[126],"was":[128,137,188,195,244],"similar":[129],"one":[132,177],"above":[133],"except":[134],"that":[135],"sampled":[138],"0,":[140],"40":[142],"60":[144],"again":[147],"2,":[149],"3,":[150],"4,":[151],"6,":[152],"8":[154],"h":[155],"All":[158],"subjects":[160,235],"completed":[161],"without":[164],"experiencing":[165],"any":[166],"adverse":[167],"or":[168],"untoward":[169],"events;":[170],"group":[173,259],"cancer":[175,237,257],"patients,":[176],"dropped":[179],"out":[180],"after":[181,215],"nose":[183],"treatment":[185,210],"when":[186],"he":[187],"removed":[189],"another":[191],"department.":[192],"This":[193],"patient":[194,258],"replaced":[196],"another,":[198],"included":[200],"final":[202],"data":[203,224],"analysis":[204],"only":[205,245],"for":[206,225],"segment":[208],"actually":[211],"received.":[212],"intravenous":[216],"dosing":[217],"good":[220],"agreement":[221],"with":[222,229],"known":[223],"active":[227],"substance,":[228],"no":[230],"meaningful":[231],"differences":[232],"between":[233],"patients.":[238],"With":[239],"MTC":[240],"administration":[242],"there":[243],"slight":[247],"but":[248],"significant":[249],"difference":[250],"Cmax,":[252],"being":[253],"lower":[254],"(p":[260],"<":[261],"005).(ABSTRACT":[262],"TRUNCATED":[263],"AT":[264],"250":[265],"WORDS)":[266]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
