{"id":"https://openalex.org/W2396664545","doi":"https://doi.org/10.1177/135965350701200204","title":"Altered Heterochromatin Organization after Perinatal Exposure to Zidovudine","display_name":"Altered Heterochromatin Organization after Perinatal Exposure to Zidovudine","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W2396664545","doi":"https://doi.org/10.1177/135965350701200204","mag":"2396664545","pmid":"https://pubmed.ncbi.nlm.nih.gov/17503660"},"language":"en","primary_location":{"id":"doi:10.1177/135965350701200204","doi":"https://doi.org/10.1177/135965350701200204","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350701200204","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109296033","display_name":"Sho Senda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sho Senda","raw_affiliation_strings":["U741, INSERM, Paris, France","UMR-S741, Universit\u00e9 Paris Diderot-Paris 7, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U741, INSERM, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR-S741, Universit\u00e9 Paris Diderot-Paris 7, Paris, France","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051621566","display_name":"St\u00e9phane Blanche","orcid":"https://orcid.org/0000-0002-2586-0686","observed_orcids":["https://orcid.org/0000-0002-2586-0686"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405261462","display_name":"Laboratoire d'h\u00e9matologie","ror":"https://ror.org/05b9w4n89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4405261462"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Blanche","raw_affiliation_strings":["EA3620, Facult\u00e9 Ren\u00e9 Descartes, Universit\u00e9 Paris Descartes, Paris, France","Unit\u00e9 d'Immunologie H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA3620, Facult\u00e9 Ren\u00e9 Descartes, Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Unit\u00e9 d'Immunologie H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4405261462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039272561","display_name":"Dominique G. Costagliola","orcid":"https://orcid.org/0000-0003-0765-0869","observed_orcids":["https://orcid.org/0000-0003-0765-0869"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Costagliola","raw_affiliation_strings":["U720, INSERM, Paris, France","UMR-S720, Facult\u00e9 de m\u00e9decine, Universit\u00e9 Pierre et Marie Curie-Paris6, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U720, INSERM, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR-S720, Facult\u00e9 de m\u00e9decine, Universit\u00e9 Pierre et Marie Curie-Paris6, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057503568","display_name":"Christian Cibert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113761","display_name":"Institut Jacques Monod","ror":"https://ror.org/02c5gc203","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210113761"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Cibert","raw_affiliation_strings":["UMRCNRS 7592, Institut Jacques Monod, Universit\u00e9 Paris Diderot-Paris7, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMRCNRS 7592, Institut Jacques Monod, Universit\u00e9 Paris Diderot-Paris7, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113761","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058946936","display_name":"Fabienne Nigon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabienne Nigon","raw_affiliation_strings":["U741, INSERM, Paris, France","UMR-S741, Universit\u00e9 Paris Diderot-Paris 7, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U741, INSERM, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR-S741, Universit\u00e9 Paris Diderot-Paris 7, Paris, France","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109076115","display_name":"Ghislaine Firtion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210097533","display_name":"Maternit\u00e9 Port Royal","ror":"https://ror.org/00x72gm71","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097533"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ghilaine Firtion","raw_affiliation_strings":["Maternit\u00e9 H\u00f4pital Cochin-Port Royal, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9 H\u00f4pital Cochin-Port Royal, Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210097533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112840702","display_name":"Corinne Floch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087884","display_name":"H\u00f4pital Louis-Mourier","ror":"https://ror.org/004nnf780","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087884","https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Floch","raw_affiliation_strings":["Maternit\u00e9, H\u00f4pital Louis Mourrier, Assistance Publique-H\u00f4pitaux de Paris, Colombes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9, H\u00f4pital Louis Mourrier, Assistance Publique-H\u00f4pitaux de Paris, Colombes, France","institution_ids":["https://openalex.org/I4210087884","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111882923","display_name":"Sophie Parat","orcid":"https://orcid.org/0000-0002-0919-728X","observed_orcids":["https://orcid.org/0000-0002-0919-728X"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Parat","raw_affiliation_strings":["Maternit\u00e9, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911183","display_name":"E. Vi\u00e9gas-P\u00e8quignot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Evani Viegas-P\u00e9quignot","raw_affiliation_strings":["U741, INSERM, Paris, France","UMR-S741, Universit\u00e9 Paris Diderot-Paris 7, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U741, INSERM, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR-S741, Universit\u00e9 Paris Diderot-Paris 7, Paris, France","institution_ids":["https://openalex.org/I4387154366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5111911183"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387154366"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.4294,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.64501223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"2","first_page":"179","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.16930000483989716,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":1.0},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/perinatal-exposure","display_name":"perinatal exposure","score":0.7059999704360962},{"id":"https://openalex.org/keywords/constitutive-heterochromatin","display_name":"constitutive heterochromatin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.7663853168487549},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.5094354748725891},{"id":"https://openalex.org/C3018923374","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Prenatal exposure","level":4,"score":0.44461894035339355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42341169714927673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40913641452789307},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.34040898084640503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2798692584037781},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2497110664844513},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.21363916993141174},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.19308391213417053},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.18565517663955688},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.11087626218795776},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002885","descriptor_name":"Chromosomes, Human, Pair 16","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/135965350701200204","doi":"https://doi.org/10.1177/135965350701200204","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135965350701200204","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:17503660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17503660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00199454v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00199454","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antiviral Therapy, 2007, 12 (2), pp.179-87","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1504303645","https://openalex.org/W1652583010","https://openalex.org/W1807570076","https://openalex.org/W1974877011","https://openalex.org/W1977339483","https://openalex.org/W1985970412","https://openalex.org/W1988744335","https://openalex.org/W1993530067","https://openalex.org/W1994598239","https://openalex.org/W2004172747","https://openalex.org/W2007478376","https://openalex.org/W2016546804","https://openalex.org/W2019468853","https://openalex.org/W2024088186","https://openalex.org/W2031087599","https://openalex.org/W2033271100","https://openalex.org/W2036813260","https://openalex.org/W2038025726","https://openalex.org/W2040271842","https://openalex.org/W2050361501","https://openalex.org/W2052244563","https://openalex.org/W2052668971","https://openalex.org/W2054748846","https://openalex.org/W2055203805","https://openalex.org/W2061471485","https://openalex.org/W2070139934","https://openalex.org/W2077339522","https://openalex.org/W2078446401","https://openalex.org/W2084412363","https://openalex.org/W2085530204","https://openalex.org/W2085560533","https://openalex.org/W2086081150","https://openalex.org/W2092263607","https://openalex.org/W2096770291","https://openalex.org/W2136905998","https://openalex.org/W2143617373","https://openalex.org/W2143773220","https://openalex.org/W2147603404","https://openalex.org/W2149372476","https://openalex.org/W2181624695","https://openalex.org/W2279697572","https://openalex.org/W2316970929","https://openalex.org/W2531331740","https://openalex.org/W4254245530"],"related_works":["https://openalex.org/W1999697653","https://openalex.org/W3137824518","https://openalex.org/W6588190","https://openalex.org/W2145875051","https://openalex.org/W2085560533","https://openalex.org/W2166970667","https://openalex.org/W2151750080","https://openalex.org/W2011188155","https://openalex.org/W7100508571","https://openalex.org/W2081954329"],"abstract_inverted_index":{"BACKGROUND:":[0],"Zidovudine":[1],"(3'-azido-3'-deoxythymidine,":[2],"AZT),":[3],"administered":[4],"to":[5,62,94,100,104,112,117,124,147,153],"pregnant":[6],"women":[7],"alone":[8],"or":[9],"in":[10,55,58,86,159,228],"combination":[11],"with":[12,66,181],"other":[13,69,107,208],"antiretroviral":[14],"drugs,":[15],"greatly":[16],"reduces":[17],"the":[18,45,79,182,202,207,212,221,224],"mother-to-child":[19],"transmission":[20],"of":[21,26,34,48,81,89,169,176,184,191,194,206,211,223,230],"HIV-1.":[22],"The":[23,156,215],"potential":[24],"genotoxicity":[25],"these":[27],"molecules":[28],"is":[29,40],"underestimated":[30],"and":[31,37,121,134,150,179,197,226,233],"wide-ranging":[32],"evaluation":[33],"its":[35,185],"biological":[36],"clinical":[38],"consequences":[39],"required.":[41],"METHODS:":[42],"We":[43,77],"investigated":[44],"nuclear":[46],"organization":[47,80],"constitutive":[49,177],"heterochromatin,":[50],"a":[51,173,188],"major":[52,174],"domain":[53],"participating":[54],"epigenetic":[56],"regulation,":[57],"uninfected":[59],"infants":[60],"born":[61,99,111,123,146,152],"HIV-1-infected":[63,101,113,148],"mothers":[64,102,114,126,149],"treated":[65],"zidovudine":[67,105],"and/or":[68,106],"nucleoside":[70],"reverse":[71],"transcriptase":[72],"inhibitors":[73],"(NRTIs)":[74],"during":[75],"pregnancy.":[76],"studied":[78],"chromosome":[82,195],"1":[83],"heterochromatin":[84,178,199,216],"(1q12)":[85],"peripheral":[87],"leukocytes":[88,229],"25":[90],"HIV-1-uninfected":[91,125],"children":[92,98,110,122,145,151],"(newborn":[93],"9":[95],"years":[96],"old):":[97],"exposed":[103,116],"NRTIs":[108,119],"(n=15),":[109],"not":[115],"any":[118],"(n=6)":[120],"(n=4).":[127],"RESULTS:":[128],"Results":[129],"differed":[130],"significantly":[131],"between":[132,143],"NRTI-exposed":[133],"-unexposed":[135],"children.":[136],"By":[137],"contrast,":[138],"there":[139],"was":[140,166],"no":[141,167],"difference":[142],"NRTI-unexposed":[144],"HIV-uninfected":[154],"mothers.":[155],"anomaly":[157],"persisted":[158],"lymphocytes":[160],"cultured":[161],"for":[162],"48":[163],"h.":[164],"There":[165],"evidence":[168],"abnormal":[170],"DNA":[171],"methylation,":[172],"feature":[175],"associated":[180],"loss":[183],"structure.":[186],"In":[187],"complementary":[189],"sample":[190],"children,":[192],"analysis":[193],"11":[196],"16":[198],"suggests":[200],"that":[201,237],"defect":[203,217],"affects":[204],"most":[205],"heterochromatic":[209],"sites":[210],"human":[213],"genome.":[214],"persists":[218],"long":[219],"after":[220],"end":[222],"exposure":[225],"appears":[227],"both":[231],"myeloid":[232],"lymphoid":[234],"lineages,":[235],"suggesting":[236],"haematopoietic":[238],"stem":[239],"cells":[240],"are":[241],"affected.":[242]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}