{"id":"https://openalex.org/W2396658786","doi":"https://doi.org/10.1177/030089169708300309","title":"Lack of Prognostic Value of p53 Protein Expression in Node-Negative Breast Cancer","display_name":"Lack of Prognostic Value of p53 Protein Expression in Node-Negative Breast Cancer","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2396658786","doi":"https://doi.org/10.1177/030089169708300309","mag":"2396658786","pmid":"https://pubmed.ncbi.nlm.nih.gov/9267486"},"language":"en","primary_location":{"id":"doi:10.1177/030089169708300309","doi":"https://doi.org/10.1177/030089169708300309","is_oa":false,"landing_page_url":"https://doi.org/10.1177/030089169708300309","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030791431","display_name":"Simonetta Bianchi","orcid":"https://orcid.org/0000-0002-2605-4758","observed_orcids":["https://orcid.org/0000-0002-2605-4758"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simonetta Bianchi","raw_affiliation_strings":["Institute of Anatomical Pathology and Histology, University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomical Pathology and Histology, University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043890978","display_name":"Anna Calzolari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Calzolari","raw_affiliation_strings":["Institute of Anatomical Pathology and Histology, University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomical Pathology and Histology, University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005304256","display_name":"Vania Vezzosi","orcid":"https://orcid.org/0000-0002-1344-4837","observed_orcids":["https://orcid.org/0000-0002-1344-4837"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vania Vezzosi","raw_affiliation_strings":["Institute of Anatomical Pathology and Histology, University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomical Pathology and Histology, University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110776195","display_name":"Giancarlo Zampi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Zampi","raw_affiliation_strings":["Institute of Anatomical Pathology and Histology, University of Florence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomical Pathology and Histology, University of Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111498347","display_name":"Gaetano Cardona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Cardona","raw_affiliation_strings":["Department of Surgery, Camerata Hospital, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Camerata Hospital, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111457671","display_name":"Luigi Cataliotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Cataliotti","raw_affiliation_strings":["Institute of Clinical Surgery I, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Surgery I, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108469037","display_name":"Rita Bonardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rita Bonardi","raw_affiliation_strings":["Center of Cancer Research and Prevention, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cancer Research and Prevention, Florence, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107865442","display_name":"Stefano Ciatto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Ciatto","raw_affiliation_strings":["Center of Cancer Research and Prevention, Florence, Italy","Department of Surgery, Camerata Hospital, Florence, Italy","Institute of Anatomical Pathology and Histology, University of Florence","Institute of Clinical Surgery I, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cancer Research and Prevention, Florence, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery, Camerata Hospital, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Institute of Anatomical Pathology and Histology, University of Florence","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Institute of Clinical Surgery I, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.9898,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.73955743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"3","first_page":"669","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-expression","display_name":"p53 expression","score":0.984000027179718},{"id":"https://openalex.org/keywords/node-negative-breast-cancer","display_name":"node-negative breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6759999990463257},{"id":"https://openalex.org/keywords/nuclear-grade","display_name":"nuclear grade","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.9200000166893005},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8980000019073486},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7811378240585327},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7684125900268555},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.7480404376983643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7254288792610168},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6514211297035217},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6403918862342834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6086722016334534},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4901481568813324},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.48689308762550354},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4808422029018402},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.46279123425483704},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.44356536865234375},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4270440936088562},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.41970324516296387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3278481960296631},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.27056360244750977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09923473000526428},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001365","descriptor_name":"Axilla","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/030089169708300309","doi":"https://doi.org/10.1177/030089169708300309","is_oa":false,"landing_page_url":"https://doi.org/10.1177/030089169708300309","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},{"id":"pmid:9267486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9267486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/206577","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/206577","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W38177479","https://openalex.org/W1970344879","https://openalex.org/W1978718921","https://openalex.org/W1979168838","https://openalex.org/W2002259547","https://openalex.org/W2029638249","https://openalex.org/W2059336275","https://openalex.org/W2098567881","https://openalex.org/W2105298270","https://openalex.org/W2111703821","https://openalex.org/W2113954582","https://openalex.org/W2116330177","https://openalex.org/W2116474489","https://openalex.org/W2181681964","https://openalex.org/W2394531554","https://openalex.org/W2396523113","https://openalex.org/W2412341678","https://openalex.org/W2616889400","https://openalex.org/W3041047318","https://openalex.org/W3147894994"],"related_works":["https://openalex.org/W2182932164","https://openalex.org/W2402384264","https://openalex.org/W2005819738","https://openalex.org/W1992890770","https://openalex.org/W2116330177","https://openalex.org/W2007833486","https://openalex.org/W2044745912","https://openalex.org/W134934188","https://openalex.org/W2034521896","https://openalex.org/W2419349840"],"abstract_inverted_index":{"AIMS":[0],"AND":[1],"BACKGROUND:":[2],"The":[3,52],"association":[4,53,104,117,142],"of":[5,30,36,39,54,66,82,99,130,171,190],"p53":[6,31,55,85,108,154,172],"protein":[7,56],"accumulation":[8,57,86],"and":[9,20,25,41,76,94,109,127,133,139,148],"prognosis":[10,59],"in":[11,22,63,174],"node-negative":[12,68,191],"breast":[13,69,192],"cancer":[14,70,193],"patients":[15,71],"has":[16],"been":[17],"alternately":[18],"demonstrated":[19],"denied":[21],"literature":[23],"reports,":[24],"opinions":[26],"on":[27,91],"the":[28,169],"use":[29,170],"expression":[32],"as":[33,42,177,183],"an":[34,178],"indicator":[35,181],"high":[37],"risk":[38],"recurrence":[40],"a":[43,64,80,115,137,184],"guide":[44],"for":[45,79,143,153,187],"adjuvant":[46,188],"therapy":[47],"are":[48],"controversial.":[49],"STUDY":[50],"DESIGN:":[51],"with":[58,73,118],"was":[60,87,105,121,159],"retrospectively":[61],"evaluated":[62],"series":[65],"221":[67],"treated":[72],"surgery":[74],"alone":[75],"followed":[77],"up":[78],"minimum":[81],"10":[83],"years.":[84],"determined":[88],"by":[89],"immunohistochemistry":[90],"archive":[92],"material,":[93],"classified":[95],"into":[96],"four":[97],"grades":[98],"increasing":[100],"immunostaining.":[101],"RESULTS:":[102],"No":[103],"observed":[106],"between":[107],"age":[110],"or":[111,182],"pT":[112],"category,":[113],"whereas":[114],"significant":[116,138],"nuclear":[119,149],"grade":[120,157],"found":[122],"(P":[123],"=":[124],"0.0014).":[125],"Univariate":[126],"multivariate":[128],"analysis":[129],"10-yr":[131],"disease-free":[132],"overall":[134],"survival":[135],"showed":[136],"independent":[140,179],"prognostic":[141,180],"tumor":[144],"size":[145],"(pT":[146],"category)":[147],"grading":[150],"but":[151],"not":[152,164],"expression,":[155],"whatever":[156],"grouping":[158],"used.":[160],"CONCLUSIONS:":[161],"We":[162],"did":[163],"find":[165],"any":[166],"evidence":[167],"supporting":[168],"immunostaining":[173],"current":[175],"practice":[176],"discriminant":[185],"factor":[186],"treatment":[189],"patients.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
