{"id":"https://openalex.org/W2396650646","doi":null,"title":"[C-peptide excretion in 24 hours-urine as an indicator of B-cell residual function in children and adolescents with type-I-diabetes (author's transl)].","display_name":"[C-peptide excretion in 24 hours-urine as an indicator of B-cell residual function in children and adolescents with type-I-diabetes (author's transl)].","publication_year":1982,"publication_date":"1982-04-01","ids":{"openalex":"https://openalex.org/W2396650646","mag":"2396650646","pmid":"https://pubmed.ncbi.nlm.nih.gov/7048077"},"language":"de","primary_location":{"id":"pmid:7048077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7048077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030517325","display_name":"Reinhard Zick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Zick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043449826","display_name":"P H\u00fcrter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P H\u00fcrter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Lange","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Lange","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173162","display_name":"H. J. Mitzkat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Mitzkat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21444122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"4","first_page":"209","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.8360000252723694},{"id":"https://openalex.org/keywords/residual-beta-cell-function","display_name":"residual beta-cell function","score":0.8960000276565552},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.8949999809265137},{"id":"https://openalex.org/keywords/diabetes-duration","display_name":"diabetes duration","score":0.8849999904632568},{"id":"https://openalex.org/keywords/insulin-requirement","display_name":"insulin requirement","score":0.8650000095367432},{"id":"https://openalex.org/keywords/beta-cell-function-decline","display_name":"beta-cell function decline","score":0.6190000176429749},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8510729074478149},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.8028704524040222},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6897545456886292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6893378496170044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6890939474105835},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6664342284202576},{"id":"https://openalex.org/C2778875212","wikidata":"https://www.wikidata.org/wiki/Q419107","display_name":"C-peptide","level":3,"score":0.6636382341384888},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5783427953720093},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5158128142356873},{"id":"https://openalex.org/C2909593344","wikidata":"https://www.wikidata.org/wiki/Q1366695","display_name":"Residual urine","level":4,"score":0.4366293251514435},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.42144858837127686},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7048077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7048077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde","raw_type":"Journal Article"},{"id":"mag:2396650646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7048077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054349458","https://openalex.org/W1968189813","https://openalex.org/W2426593817","https://openalex.org/W2062358800","https://openalex.org/W2018037892","https://openalex.org/W2089373039","https://openalex.org/W2911426571","https://openalex.org/W956982966","https://openalex.org/W2120781934","https://openalex.org/W2472372750"],"abstract_inverted_index":{"In":[0,112],"140":[1],"juvenile":[2],"diabetics":[3,80],"residual":[4,41,73,133],"B-cell-function":[5],"was":[6,54],"measured":[7],"according":[8],"to":[9,24,89,105,148,205],"the":[10,13,18,64,69,72,79,98,120,142,151,159,172,175,178,181,196,206],"amount":[11],"of":[12,33,66,71,78,119,131,141,170,174,180,195,208],"immunoreactive":[14],"C-peptide":[15,75,176],"(IRCP)":[16],"in":[17,31],"24":[19],"h-urine.":[20],"We":[21],"were":[22,82,163,185],"able":[23],"repeat":[25],"this":[26],"test":[27],"after":[28],"two":[29],"years":[30,157],"69":[32],"these":[34],"patients.":[35],"All":[36],"diabetic":[37],"children":[38,114,149],"showed":[39,126],"maintained":[40],"insulin":[42,100,144,183],"secretion":[43],"(mean":[44],"+/-":[45,49],"S":[46],"mean":[47],"2.60":[48],"0.31":[50],"nmol/24":[51],"h).":[52],"There":[53],"a":[55,116,127,137,167],"significant":[56],"negative":[57],"relationship":[58],"(p":[59,188],"less":[60,94,109,189],"than":[61,95,110,123,155,190],"0.001)":[62],"between":[63],"duration":[65,118],"diabetes":[67,121,152,171],"and":[68,97,177],"extend":[70],"B-cell-function.":[74],"urine":[76],"excretion":[77],"who":[81],"followed":[83],"up":[84],"dropped":[85],"significantly":[86,103],"(0.08":[87],"down":[88],"0.02":[90],"nmol/kg/24":[91],"h,":[92],"p":[93,108],"0.001),":[96],"daily":[99,143,182],"requirement":[101],"increased":[102],"(0.36":[104],"0.67":[106],"U/kg,":[107],"0.05).":[111],"comparison,":[113],"with":[115,136,150],"shorter":[117],"(less":[122],"3":[124,156],"years)":[125],"more":[128],"rapid":[129],"decrease":[130,173],"their":[132],"B-cell":[134,209],"function":[135],"simultaneously":[138],"greater":[139],"increase":[140,179],"dose":[145,184],"as":[146,199],"opposed":[147],"for":[153],"longer":[154],"at":[158],"time":[160],"when":[161],"they":[162],"first":[164],"seen.":[165],"With":[166],"short":[168],"course":[169],"negatively":[186],"correlated":[187],"0.001).":[191],"The":[192],"clinical":[193],"phenomena":[194],"remission":[197],"period":[198],"known":[200],"until":[201],"now":[202],"are":[203],"related":[204],"decline":[207],"function.":[210]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}