{"id":"https://openalex.org/W2396615909","doi":null,"title":"[Comparison of the effect of Angelica polysaccharide, platelet-derived growth factor and thrombopoietin on megakaryocytopoiesis].","display_name":"[Comparison of the effect of Angelica polysaccharide, platelet-derived growth factor and thrombopoietin on megakaryocytopoiesis].","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2396615909","mag":"2396615909","pmid":"https://pubmed.ncbi.nlm.nih.gov/18353239"},"language":"zh","primary_location":{"id":"pmid:18353239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18353239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua er ke za zhi = Chinese journal of pediatrics","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060304821","display_name":"Shu Mo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159428","display_name":"Children's Hospital of Chongqing Medical University","ror":"https://ror.org/05pz4ws32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159428"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Mo","raw_affiliation_strings":["Department of Hematology/Oncology, Chongqing Children's Hospital, Chongqing Medical University, Chongqing 400014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Chongqing Children's Hospital, Chongqing Medical University, Chongqing 400014, China","institution_ids":["https://openalex.org/I4210159428","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672930","display_name":"Jie Yu","orcid":"https://orcid.org/0000-0002-7987-0599","observed_orcids":["https://orcid.org/0000-0002-7987-0599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112130452","display_name":"Mo Yang","orcid":"https://orcid.org/0009-0004-5119-4842","observed_orcids":["https://orcid.org/0009-0004-5119-4842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mo Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027800938","display_name":"Zhi-guang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-guang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090563684","display_name":"Guixia Li","orcid":"https://orcid.org/0000-0003-3948-7488","observed_orcids":["https://orcid.org/0000-0003-3948-7488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gui-xia Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100726868","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-4938-096X","observed_orcids":["https://orcid.org/0000-0002-4938-096X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31231602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"1","first_page":"45","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angelica-polysaccharide","display_name":"Angelica polysaccharide","score":0.996999979019165},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":1.0},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/megakaryocyte-proliferation","display_name":"megakaryocyte proliferation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6819999814033508},{"id":"https://openalex.org/keywords/platelet-indices","display_name":"platelet indices","score":0.4000000059604645},{"id":"https://openalex.org/keywords/platelet-morphology","display_name":"platelet morphology","score":0.33000001311302185},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.3799999952316284},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.45399999618530273},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.7884727716445923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7017651796340942},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.678756058216095},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.617406964302063},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.6169387698173523},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.6093257665634155},{"id":"https://openalex.org/C2777918643","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocytopoiesis","level":5,"score":0.5719097256660461},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5586350560188293},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5050581097602844},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.49060097336769104},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.48981043696403503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4219197630882263},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37777939438819885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33071035146713257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21582475304603577},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.1572953164577484},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.12956956028938293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09925681352615356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08920344710350037},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002232","descriptor_name":"Carbocyanines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D029969","descriptor_name":"Angelica","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D034061","descriptor_name":"Thrombopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:18353239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18353239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua er ke za zhi = Chinese journal of pediatrics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2991760544","https://openalex.org/W2579419677","https://openalex.org/W2093222242","https://openalex.org/W1997942538","https://openalex.org/W2006840197","https://openalex.org/W1964193188","https://openalex.org/W2367461710","https://openalex.org/W7118965","https://openalex.org/W1510842546","https://openalex.org/W1979028006"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,17,31,83,87,89,95,103,106,113,123,154,163,167,185,194,207,224,233],"effect":[4,265],"of":[5,21,34,76,91,105,162,169,202,274],"Angelica":[6],"polysaccharide":[7],"(APS),":[8],"platelet-derived":[9],"growth":[10],"factor":[11],"(PDGF)":[12],"and":[13,19,30,48,68,98,102,126,136,172,181,187,210,220,245,248,251,261,269],"thrombopoietin":[14],"(TPO)":[15],"on":[16],"proliferation":[18,268],"apoptosis":[20,59,273],"human":[22],"megakaryocytic":[23],"cell":[24,204],"line":[25],"M-07e.":[26],"METHODS:":[27],"Cell":[28],"count":[29],"viability":[32],"testing":[33],"M-07e":[35,92,275],"cells":[36,93,121],"(trypan":[37],"blue":[38],"exclusion":[39],"assay)":[40],"were":[41,70,109,129,149,174,213,254],"performed":[42,71],"at":[43,79],"24":[44],"hours,":[45],"48":[46],"hours":[47,50,81],"72":[49,80],"after":[51,82],"treatment":[52],"with":[53],"APS,":[54,96,124,170,208,259],"PDGF":[55,97,125,171,188,209,246,260],"or":[56],"TPO.":[57],"Three":[58],"related":[60],"flow":[61,142],"cytometric":[62],"assays":[63],"including":[64],"Annexin":[65,145],"V,":[66],"Caspase-3":[67],"JC-1":[69,240],"to":[72,153,193,232],"determine":[73],"apoptotic":[74],"rate":[75],"each":[77],"group":[78,100,115,128,156,168,189,196,212,228,235],"treatment.":[84],"RESULTS:":[85],"After":[86],"incubation,":[88],"number":[90],"in":[94,122,166,206,226,266],"TPO":[99,127,173,211,252,262],"increased":[101],"viabilities":[104],"three":[107],"groups":[108,247,253],"significantly":[110,150,191,230],"higher":[111],"than":[112],"control":[114,155,195,234],"(P":[116],"<":[117],"0.05).":[118],"The":[119,160,200],"dead":[120],"(19.41":[130],"+/-":[131,134,138,158,176,179,183,198,215,218,222,237],"7.59)%,":[132],"(21.38":[133],"7.25)%":[135],"(18.77":[137],"8.00)%,":[139],"respectively":[140],"by":[141,239],"cytometry":[143],"using":[144],"V":[146],"method,":[147],"which":[148],"lower":[151],"compared":[152,192,231],"(34.33":[157],"5.46)%.":[159],"expression":[161],"activated":[164],"caspase-3":[165],"(12.27":[175],"5.18)%,":[177],"(12.39":[178],"6.26)%":[180],"(13.75":[182],"8.25)%,":[184],"APS":[186,227,244,250],"decreased":[190,229],"(18.92":[197],"6.09)%.":[199],"ratio":[201,225],"total":[203],"deaths":[205],"(23.64":[214],"6.69)%,":[216],"(28.00":[217],"10.05)%":[219],"(27.99":[221],"8.99)%,":[223],"(39.48":[236],"11.86)%":[238],"method.":[241],"Differences":[242],"between":[243,249],"not":[255],"statistically":[256],"significant.":[257],"CONCLUSION:":[258],"have":[263],"similar":[264],"stimulating":[267],"inhibiting":[270],"serum-free-culture":[271],"induced":[272],"cells.":[276]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
