{"id":"https://openalex.org/W2396612800","doi":null,"title":"miR-125b regulates cell progression in chronic myeloid leukemia via targeting BAK1.","display_name":"miR-125b regulates cell progression in chronic myeloid leukemia via targeting BAK1.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2396612800","mag":"2396612800","pmid":"https://pubmed.ncbi.nlm.nih.gov/27158338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4846895"},"language":"en","primary_location":{"id":"pmid:27158338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27158338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4846895/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101860410","display_name":"Quan Li","orcid":"https://orcid.org/0000-0003-4776-8300","observed_orcids":["https://orcid.org/0000-0003-4776-8300"]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Li","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103076014","display_name":"Yaohui Wu","orcid":"https://orcid.org/0000-0002-9888-3731","observed_orcids":["https://orcid.org/0000-0002-9888-3731"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaohui Wu","raw_affiliation_strings":["Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739743","display_name":"Yongkang Zhang","orcid":"https://orcid.org/0000-0002-2156-6762","observed_orcids":["https://orcid.org/0000-0002-2156-6762"]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkang Zhang","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042751662","display_name":"Huapeng Sun","orcid":"https://orcid.org/0000-0001-9797-0510","observed_orcids":["https://orcid.org/0000-0001-9797-0510"]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huapeng Sun","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100967505","display_name":"Zhaoli Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoli Lu","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ke Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Du","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shanshan Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Fang","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Jinzhou Road 136, Xiangyang 441053, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083084563","display_name":"Weiming Li","orcid":"https://orcid.org/0000-0001-6276-1989","observed_orcids":["https://orcid.org/0000-0001-6276-1989"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiming Li","raw_affiliation_strings":["Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1277 Jiefang Avenue, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1277 Jiefang Avenue, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1763,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74469325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"2","first_page":"447","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.09160000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-125b","display_name":"miR-125b","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bak1","display_name":"BAK1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6890000104904175},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9879999756813049},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5659999847412109},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.786034107208252},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.678997278213501},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6594792604446411},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6476754546165466},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.583479642868042},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.573209285736084},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5023488998413086},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4960654675960541},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4959894120693207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4276067912578583},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33232036232948303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3288276195526123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2913646697998047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2821015417575836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1260388195514679},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05555078387260437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:27158338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27158338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4846895","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4846895/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2396612800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27158338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4846895","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4846895/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1515233962","https://openalex.org/W1724536330","https://openalex.org/W1849737288","https://openalex.org/W1951421707","https://openalex.org/W1966197722","https://openalex.org/W1970519397","https://openalex.org/W1974254202","https://openalex.org/W1995973970","https://openalex.org/W1998809856","https://openalex.org/W2002800994","https://openalex.org/W2004503198","https://openalex.org/W2008326956","https://openalex.org/W2011058968","https://openalex.org/W2012153991","https://openalex.org/W2016656445","https://openalex.org/W2020882345","https://openalex.org/W2021929002","https://openalex.org/W2024842934","https://openalex.org/W2034437737","https://openalex.org/W2035243232","https://openalex.org/W2037382204","https://openalex.org/W2069540657","https://openalex.org/W2134055438","https://openalex.org/W2141888384","https://openalex.org/W2144427644","https://openalex.org/W2155396586","https://openalex.org/W2158214783","https://openalex.org/W2158556487"],"related_works":["https://openalex.org/W4285124908","https://openalex.org/W2923411020","https://openalex.org/W4401886454","https://openalex.org/W2968734751","https://openalex.org/W2334151113","https://openalex.org/W2610648374","https://openalex.org/W7204689157","https://openalex.org/W2980764543","https://openalex.org/W2992885855","https://openalex.org/W6887605067"],"abstract_inverted_index":{"Chronic":[0],"myeloid":[1],"leukemia":[2],"(CML)":[3],"is":[4],"a":[5,15,256],"type":[6],"of":[7,14,18,37,49,65,72,102,117,143,151,169,187,212,217,230,235,249],"malignant":[8],"tumor":[9,245],"characterized":[10],"by":[11,183],"the":[12,24,34,47,63,70,88,93,103,115,120,131,141,149,155,159,166,170,185,210,215,239],"accumulation":[13],"large":[16],"number":[17],"immature":[19],"white":[20],"blood":[21,25],"cells":[22],"in":[23,51,76,134,173,190,202,238,251],"and":[26,79,97,123,137,145,147,153,222,243,247],"bone":[27],"marrow.":[28],"BAK1":[29,73,98,144],"was":[30,43],"predicted":[31],"to":[32,45,227],"be":[33],"target":[35],"gene":[36],"microRNA-451":[38],"(miR-125b).":[39],"The":[40],"present":[41],"study":[42,207],"designed":[44],"illustrate":[46],"mechanism":[48],"miR-125b":[50,66,96,104,107,118,156,171,178,197,213],"regulating":[52],"CML":[53,77,80,110,200,250],"via":[54],"targeting":[55],"BAK1.":[56,188],"In":[57,162],"this":[58],"study,":[59],"we":[60,112],"found":[61,113],"that":[62,114,177,209],"expression":[64,71,142,150,186,216,229,234],"increased":[67,140],"strongly,":[68],"whereas":[69],"decreased":[74,119,148,244],"significantly":[75],"patients":[78],"cell":[81,127,220,224],"lines":[82],"compared":[83],"with":[84,126],"healthy":[85],"controls.":[86],"Moreover,":[87],"luciferase":[89],"report":[90],"assay":[91],"confirmed":[92],"interaction":[94],"between":[95],"mRNA.":[99],"After":[100],"transfection":[101],"mimic":[105,157],"or":[106],"inhibitor":[108,172],"into":[109],"cells,":[111,139,175],"inhibition":[116],"proliferation":[121],"rates":[122],"promoted":[124],"apoptosis":[125,221],"cycle":[128],"arrest":[129],"at":[130],"G0/G1":[132],"phase":[133],"both":[135],"K562":[136,174],"NB-4":[138],"Caspase-3,":[146],"Bcl-2":[152],"c-myc;":[154],"yielded":[158],"opposite":[160],"results.":[161],"addition,":[163],"siBAK1":[164],"offset":[165],"suppression":[167,198],"effect":[168],"indicating":[176],"promotes":[179,219],"these":[180,194],"cellular":[181],"processes":[182],"inhibiting":[184],"Further":[189],"vivo":[191],"experiments":[192],"supported":[193],"findings":[195],"because":[196],"reduced":[199],"growth":[201],"mice.":[203],"Taken":[204],"together,":[205],"our":[206],"suggests":[208],"down-regulation":[211],"affects":[214],"BAK1,":[218],"inhibits":[223],"proliferation,":[225],"leading":[226],"up-regulated":[228],"pro-apoptosis":[231],"factors,":[232],"down-regulated":[233],"anti-apoptosis":[236],"factors":[237],"mitochondrial":[240],"apoptotic":[241],"pathway,":[242],"size":[246],"weight":[248],"vivo.":[252],"These":[253],"results":[254],"provide":[255],"potential":[257],"therapeutic":[258],"strategy":[259],"for":[260],"CML.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}