{"id":"https://openalex.org/W2396598809","doi":null,"title":"[Early cirrhosis, an early modality of the evolution of acute hepatitis. The clinico-biological, immunological and morphological aspects].","display_name":"[Early cirrhosis, an early modality of the evolution of acute hepatitis. The clinico-biological, immunological and morphological aspects].","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2396598809","mag":"2396598809","pmid":"https://pubmed.ncbi.nlm.nih.gov/1982190"},"language":"ro","primary_location":{"id":"pmid:1982190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1982190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078092354","display_name":"T Banciu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Banciu","raw_affiliation_strings":["Clinica IV Medical\u0103, I.M. Timi\u015foara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica IV Medical\u0103, I.M. Timi\u015foara","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032619437","display_name":"Nicu Constantin Tudose","orcid":"https://orcid.org/0000-0002-4814-8886","observed_orcids":["https://orcid.org/0000-0002-4814-8886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Tudose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089810037","display_name":"P Arcan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Arcan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30652632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"2","first_page":"167","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-hepatitis","display_name":"acute hepatitis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.9139999747276306},{"id":"https://openalex.org/keywords/alcoholic-hepatitis","display_name":"alcoholic hepatitis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/dyspepsia","display_name":"dyspepsia","score":0.828000009059906},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.7870000004768372},{"id":"https://openalex.org/keywords/bilirubinemia","display_name":"bilirubinemia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hypoproteinemia","display_name":"hypoproteinemia","score":0.7409999966621399},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.8820000290870667},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7418895363807678},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.6336938738822937},{"id":"https://openalex.org/C3018886096","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Acute hepatitis","level":3,"score":0.6231849789619446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5790805816650391},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.5576876997947693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5237143635749817},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5163778066635132},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.4517499804496765},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41656461358070374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33590012788772583},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3207359313964844},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.22080102562904358},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006519","descriptor_name":"Hepatitis, Alcoholic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008104","descriptor_name":"Liver Cirrhosis, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1982190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1982190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","raw_type":"English Abstract"},{"id":"mag:2396598809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1982190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2440857951","https://openalex.org/W2057564500","https://openalex.org/W2142146171","https://openalex.org/W274527891","https://openalex.org/W2425423679","https://openalex.org/W2107349526","https://openalex.org/W2410561987","https://openalex.org/W2384532072","https://openalex.org/W2406779532","https://openalex.org/W4237759491"],"abstract_inverted_index":{"A":[0],"group":[1],"of":[2,43,48,54,59,68,76,81,88,94,99,113],"12":[3],"patients":[4],"with":[5,10,14],"recent":[6],"acute":[7,49],"hepatitis":[8],"(8/86":[9],"HVB":[11],"and":[12,32,57,74,93,103],"4/22":[13],"alcoholic":[15],"hepatitis)":[16],"had":[17],"a":[18,52],"rapid":[19],"evolution":[20,47],"(under":[21],"2":[22],"years)":[23],"towards":[24,83],"hepatic":[25,119],"cirrhosis":[26],"(early":[27],"H.C.).":[28],"The":[29,106],"clinical-biological,":[30],"immunological":[31],"morphological":[33],"study":[34],"made":[35],"evident":[36],"several":[37,60],"characteristics,":[38],"which":[39],"became":[40],"predictive":[41],"markers":[42],"the":[44,66,79,86,89,97,100,114,117],"early":[45,118],"cirrhotic":[46],"hepatitis.":[50],"Clinically,":[51],"persistence":[53],"dyspeptic":[55],"disorders":[56],"appearance":[58],"systemic":[61],"manifestations":[62],"is":[63,109],"noticed.":[64],"Biologically,":[65],"maintenance":[67],"some":[69],"increased":[70,84],"transmainases,":[71],"variable":[72],"bilirubinemia":[73],"decrease":[75,87],"serinemia.":[77],"Immunologically,":[78],"transfer":[80],"IgM":[82],"IgM,":[85],"total":[90],"T":[91,104],"lymphocyte":[92],"T1":[95],"substrate,":[96],"increase":[98],"active":[101],"B":[102],"lymphocyte.":[105],"morphologic":[107],"exploration":[108],"decisive":[110],"for":[111],"specification":[112],"diagnosis":[115],"in":[116],"cirrhosis.":[120]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}