{"id":"https://openalex.org/W2396596957","doi":null,"title":"Circulating atrial natriuretic polypeptide during exercise in patients with essential hypertension.","display_name":"Circulating atrial natriuretic polypeptide during exercise in patients with essential hypertension.","publication_year":1986,"publication_date":"1986-12-01","ids":{"openalex":"https://openalex.org/W2396596957","mag":"2396596957","pmid":"https://pubmed.ncbi.nlm.nih.gov/2956390"},"language":"en","primary_location":{"id":"pmid:2956390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2956390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension. Supplement : official journal of the International Society of Hypertension","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028636839","display_name":"Toshio Nishikimi","orcid":"https://orcid.org/0000-0001-8595-3780","observed_orcids":["https://orcid.org/0000-0001-8595-3780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nishikimi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020356581","display_name":"Michiaki Kohno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kohno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Matsuura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Matsuura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113643271","display_name":"Yoshiharu Kanayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kanayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088983400","display_name":"Kaname Akioka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Akioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039593395","display_name":"Masakazu Teragaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Teragaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Yasuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yasuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005203825","display_name":"Hisao Oku","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Oku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112718537","display_name":"Kazuhide Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Takeuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T Takeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Takeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.146,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.87429379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"4","issue":"6","first_page":"S546","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.04879999905824661,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9599999785423279},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pulmonary-capillary-wedge-pressure","display_name":"pulmonary capillary wedge pressure","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.9330000281333923},{"id":"https://openalex.org/keywords/left-ventricular-systolic-dysfunction","display_name":"left ventricular systolic dysfunction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/left-atrial-pressure","display_name":"left atrial pressure","score":0.8659999966621399},{"id":"https://openalex.org/keywords/fractional-shortening","display_name":"fractional shortening","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8760098218917847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8384685516357422},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.737025260925293},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7197498083114624},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.7158243656158447},{"id":"https://openalex.org/C146556889","wikidata":"https://www.wikidata.org/wiki/Q1414127","display_name":"Pulmonary wedge pressure","level":3,"score":0.5957729816436768},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5809483528137207},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5264837741851807},{"id":"https://openalex.org/C35207712","wikidata":"https://www.wikidata.org/wiki/Q190402","display_name":"Central venous pressure","level":4,"score":0.493208110332489},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.4606468975543976},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.43720531463623047},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.41250383853912354},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3896358907222748},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3249094486236572},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25470155477523804}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011669","descriptor_name":"Pulmonary Wedge Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2956390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2956390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension. Supplement : official journal of the International Society of Hypertension","raw_type":"Journal Article"},{"id":"mag:2396596957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2956390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131600578","https://openalex.org/W2473933886","https://openalex.org/W2184379532","https://openalex.org/W2084376098","https://openalex.org/W2091256494","https://openalex.org/W2039931299","https://openalex.org/W2009125823","https://openalex.org/W2065319800","https://openalex.org/W2090956267","https://openalex.org/W1992024638"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,67,149],"relationship":[3],"between":[4,118],"haemodynamic":[5,44],"measurements":[6],"and":[7,32,43,49,58,75,91,126,169],"plasma":[8,81,127],"atrial":[9,167],"natriuretic":[10],"peptide":[11],"(ANP)":[12],"levels":[13,42,57,83,129,154],"during":[14,50,92,155],"exercise":[15,22,96,156],"in":[16,157],"patients":[17],"with":[18,164],"essential":[19,158],"hypertension.":[20],"The":[21],"protocol":[23],"consisted":[24],"of":[25,53,73,95,151],"three":[26],"fixed":[27],"work":[28,69,133],"loads":[29],"(25,":[30],"50":[31],"75":[33,131],"W)":[34],"using":[35],"a":[36,114],"supine":[37],"bicycle":[38],"ergometer.":[39],"Plasma":[40,55],"ANP":[41,56,82,128,153],"indices":[45],"were":[46,84],"measured":[47],"before":[48,90],"each":[51,93],"stage":[52,94],"exercise.":[54],"pulmonary":[59],"artery":[60],"wedge":[61],"pressure":[62,78,168],"(PAWP)":[63],"significantly":[64],"increased":[65],"at":[66,86,130],"maximum":[68],"load.":[70],"Significant":[71],"correlations":[72],"PAWP":[74],"mean":[76],"arterial":[77,170],"(MAP)":[79],"to":[80],"observed":[85,137],"four":[87],"points":[88],"obtained":[89],"(PAWP,":[97],"r":[98,106],"=":[99,107,139],"0.83,":[100],"P":[101,109,141],"less":[102,110,142],"than":[103,111,143],"0.001;":[104],"MAP,":[105],"0.48,":[108],"0.01).":[112,144],"Furthermore,":[113],"significant":[115],"inverse":[116],"correlation":[117],"shortening":[119],"fraction":[120],"(SF),":[121],"estimated":[122],"by":[123],"M-mode":[124],"echocardiography,":[125],"W":[132],"load":[134],"was":[135],"also":[136],"(r":[138],"-0.66,":[140],"These":[145],"results":[146],"suggest":[147],"that":[148],"increase":[150],"circulating":[152],"hypertensive":[159],"subjects":[160],"may":[161],"be":[162],"associated":[163],"elevated":[165],"left":[166,173],"pressure,":[171],"or":[172],"ventricular":[174],"systolic":[175],"dysfunction.":[176]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}