{"id":"https://openalex.org/W2396595108","doi":null,"title":"Clinical findings with nimodipine in dementia: test of the calcium hypothesis.","display_name":"Clinical findings with nimodipine in dementia: test of the calcium hypothesis.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2396595108","mag":"2396595108","pmid":"https://pubmed.ncbi.nlm.nih.gov/8821080"},"language":"en","primary_location":{"id":"pmid:8821080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8821080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission. Supplementum","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109928632","display_name":"J. Fritze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Fritze","raw_affiliation_strings":["Department of Psychiatry, University of Frankfurt, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Frankfurt, Federal Republic of Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002883235","display_name":"J. Walden","orcid":"https://orcid.org/0000-0001-5068-4568","observed_orcids":["https://orcid.org/0000-0001-5068-4568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Walden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1373,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.78508342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"46","issue":null,"first_page":"439","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.23520000278949738,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nimodipine","display_name":"nimodipine","score":1.0},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/calcium-hypothesis","display_name":"calcium hypothesis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/calcium-toxicity","display_name":"calcium toxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8809999823570251},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ischemic-brain-lesions","display_name":"ischemic brain lesions","score":0.7699999809265137},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.8849999904632568},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2777294900","wikidata":"https://www.wikidata.org/wiki/Q421429","display_name":"Nimodipine","level":3,"score":0.9350002408027649},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7866969108581543},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5149189233779907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5108320713043213},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5035845637321472},{"id":"https://openalex.org/C2780356492","wikidata":"https://www.wikidata.org/wiki/Q421700","display_name":"Calcium channel blocker","level":3,"score":0.4963584542274475},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.48830556869506836},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.48708274960517883},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47593119740486145},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.46066585183143616},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.44332364201545715},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38123196363449097},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34079623222351074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32876449823379517},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11470842361450195}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009553","descriptor_name":"Nimodipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018849","descriptor_name":"Controlled Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8821080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8821080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission. Supplementum","raw_type":"Journal Article"},{"id":"mag:2396595108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8821080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1584077124","https://openalex.org/W2008171469","https://openalex.org/W2168159865","https://openalex.org/W2413204268","https://openalex.org/W1529339318","https://openalex.org/W130126858","https://openalex.org/W2082832866","https://openalex.org/W4366272286","https://openalex.org/W1565992055","https://openalex.org/W7099625361"],"abstract_inverted_index":{"Calcium":[0],"toxicity":[1,68],"seems":[2],"to":[3,41,51,54,77,94,107],"be":[4,52,70],"involved":[5],"in":[6,11,16,56,62,81,98],"ischemic":[7],"brain":[8],"lesions":[9],"like":[10,101],"vascular":[12],"dementia":[13,19,63,100],"and":[14,33,104],"possibly":[15],"primary":[17],"degenerative":[18],"of":[20,45,60,66],"Alzheimer's":[21],"type.":[22],"The":[23],"calcium":[24,46,67],"channel":[25],"blocker":[26],"nimodipine":[27,49],"readily":[28],"passes":[29],"the":[30,43,64,82,88,105],"blood-brain":[31],"barrier":[32],"may":[34],"thus":[35],"serve":[36],"as":[37,72,85,87],"a":[38,57],"pharmacologic":[39],"probe":[40],"test":[42],"hypothesis":[44],"toxicity.":[47],"Although":[48],"proved":[50],"superior":[53],"placebo":[55],"considerable":[58],"amount":[59],"studies":[61],"concept":[65],"cannot":[69],"accepted":[71],"established.":[73],"This":[74],"is":[75,110],"due":[76],"some":[78],"methodological":[79],"flaws":[80],"clinical":[83],"trials":[84],"well":[86],"limited":[89],"effect":[90],"size.":[91],"Moreover,":[92],"bridging":[93],"other":[95],"findings":[96],"especially":[97],"Alzheimer-type":[99],"amyloid":[102],"deposition":[103],"relationship":[106],"apolipoprotein-E":[108],"isotypes":[109],"still":[111],"far":[112],"from":[113],"complete.":[114]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
