{"id":"https://openalex.org/W2396512995","doi":null,"title":"Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease.","display_name":"Rectal substance P concentrations are increased in ulcerative colitis but not in Crohn's disease.","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2396512995","mag":"2396512995","pmid":"https://pubmed.ncbi.nlm.nih.gov/7684884"},"language":"en","primary_location":{"id":"pmid:7684884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7684884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112834276","display_name":"C N Bernstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C N Bernstein","raw_affiliation_strings":["Inflammatory Bowel Disease Center, Harbor-UCLA Medical Center, Torrance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammatory Bowel Disease Center, Harbor-UCLA Medical Center, Torrance","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065404892","display_name":"Marie E. Robert","orcid":"https://orcid.org/0000-0002-6385-4578","observed_orcids":["https://orcid.org/0000-0002-6385-4578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Robert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111745150","display_name":"V. E. Eysselein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V E Eysselein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0652,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.87315749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"88","issue":"6","first_page":"908","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":1.0},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/rectal-mucosa","display_name":"rectal mucosa","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease-pathogenesis","display_name":"inflammatory bowel disease pathogenesis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.908839762210846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.860551118850708},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7830502390861511},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7647416591644287},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.755452036857605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7037095427513123},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5291849970817566},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.48477834463119507},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.4720141589641571},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42695122957229614},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3458358645439148},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.16306594014167786},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08580410480499268}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7684884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7684884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Comparative Study"},{"id":"mag:2396512995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7684884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002078683","https://openalex.org/W1986569386","https://openalex.org/W2047624440","https://openalex.org/W2035787320","https://openalex.org/W3093324808","https://openalex.org/W1967620034","https://openalex.org/W1966318970","https://openalex.org/W2414292426","https://openalex.org/W2152833770","https://openalex.org/W4240724239"],"abstract_inverted_index":{"Substance":[0],"P,":[1],"a":[2,133,219],"neurotransmitter":[3],"found":[4],"in":[5,23,45,74,96,103,205,222,237,248,268],"colonic":[6],"mucosa,":[7],"can":[8],"alter":[9],"gut":[10],"immunologic,":[11],"vascular,":[12],"and":[13,30,61,84,128,143,164,175,182,189,209,270],"motor":[14],"phenomena.":[15],"Thus,":[16,214],"it":[17],"may":[18,217,257],"have":[19,218],"an":[20],"important":[21],"role":[22,221],"the":[24,37,126,183,199,223,234,244,260,264,274,280,286],"pathogenesis":[25,224],"of":[26,36,39,71,121,186,225,227,263],"ulcerative":[27],"colitis":[28],"(UC)":[29],"Crohn's":[31],"disease":[32,56],"(CD).":[33],"By":[34],"radioimmunoassay":[35],"extracts":[38],"endoscopically":[40],"obtained":[41],"rectal":[42,111,123,138,159,177,200],"mucosal":[43,50,94,139,160,165,178,187,201,253],"biopsies":[44,62],"affected":[46],"patients,":[47,130],"we":[48],"evaluated":[49],"substance":[51,72,140,161,179,202,215,254],"P":[52,73,141,162,180,203,216,255],"levels.":[53],"Non-inflammatory":[54],"bowel":[55],"patients":[57,75,87,98,117,206,238],"undergoing":[58],"lower":[59,101,114],"endoscopies":[60],"served":[63],"as":[64],"controls.":[65],"There":[66],"were":[67,99],"significantly":[68,100,212],"increased":[69,245],"concentrations":[70,142,163,181,204,236],"with":[76,79,86,88,109,118,207,239],"UC,":[77],"compared":[78,85],"controls":[80,104],"(p":[81,90,105],"<":[82,91,106],"0.05)":[83],"CD":[89,97,112,127,210],"0.005).":[92],"The":[93],"levels":[95,115,256],"than":[102,116,273],"0.05).":[107],"Patients":[108],"active":[110,122],"had":[113],"no":[119],"evidence":[120],"disease.":[124],"For":[125],"UC":[129,208,240,269],"there":[131],"was":[132],"strongly":[134],"positive":[135],"correlation":[136,156],"between":[137],"total":[144],"histologic":[145],"inflammation":[146,246],"scores":[147,168,185],"(r":[148,169,191],"=":[149,152,170,173,192,195],"0.7,":[150,171,193],"p":[151,172,194],"0.001).":[153],"A":[154],"strong":[155],"existed":[157],"for":[158,176],"mononuclear":[166],"cell":[167],"0.001)":[174],"combined":[184],"neutrophils":[188],"eosinophils":[190],"0.002).":[196],"In":[197],"conclusion,":[198],"are":[211,241,283],"different.":[213],"different":[220,265],"each":[226],"these":[228,249],"entities.":[229],"It":[230,276],"is":[231,277],"possible":[232,278],"that":[233,279],"elevated":[235],"contributing":[242,284],"to":[243,285],"seen":[247],"patients.":[250],"Alternatively,":[251],"measured":[252,287],"simply":[258],"reflect":[259],"end":[261],"result":[262],"inflammatory":[266,281],"processes":[267],"CD,":[271],"rather":[272],"cause.":[275],"cells":[282],"concentrations.":[288]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}