{"id":"https://openalex.org/W2396510141","doi":null,"title":"[Combined effect of doxorubicine and dehydroepiandrosterone on proliferation and oxidative stress in Saccharomyces cerevisiae cells].","display_name":"[Combined effect of doxorubicine and dehydroepiandrosterone on proliferation and oxidative stress in Saccharomyces cerevisiae cells].","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2396510141","mag":"2396510141","pmid":"https://pubmed.ncbi.nlm.nih.gov/20486557"},"language":"ru","primary_location":{"id":"pmid:20486557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20486557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eksperimental'naia i klinicheskaia farmakologiia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040399254","display_name":"Yury Saenko","orcid":"https://orcid.org/0000-0002-4402-1482","observed_orcids":["https://orcid.org/0000-0002-4402-1482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iu V Saenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113752351","display_name":"Napalkova Sm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Napalkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E Sh Enikeev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Sh Enikeev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022879259","display_name":"Evgeniya Vladimirovna Rastorgueva","orcid":"https://orcid.org/0000-0003-1518-4677","observed_orcids":["https://orcid.org/0000-0003-1518-4677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E V Rastorgueva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"73","issue":"4","first_page":"31","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.07270000129938126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":1.0},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ribonucleotide-reductase","display_name":"ribonucleotide reductase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5410000085830688},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8566733598709106},{"id":"https://openalex.org/C4710235","wikidata":"https://www.wikidata.org/wiki/Q420089","display_name":"Ribonucleotide reductase","level":4,"score":0.7841271758079529},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.6993564963340759},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6977595686912537},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6663466691970825},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5958520174026489},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.5952402949333191},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5670779943466187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5349743366241455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4524978995323181},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4283849596977234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3899881839752197},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3382801413536072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3320009112358093},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2835997939109802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2608411908149719},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.1628006100654602},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.13820987939834595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1348540186882019},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12101864814758301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.0},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012264","descriptor_name":"Ribonucleotide Reductases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:20486557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20486557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eksperimental'naia i klinicheskaia farmakologiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992173311","https://openalex.org/W2061720736","https://openalex.org/W2154836031","https://openalex.org/W2001393578","https://openalex.org/W4240438648","https://openalex.org/W3092265513","https://openalex.org/W1996700809","https://openalex.org/W2139947047","https://openalex.org/W2384583431","https://openalex.org/W2043448301"],"abstract_inverted_index":{"Results":[0],"of":[1,5,8,45,51,72,83,94,98,105,120,123,128,137],"a":[2,78,88,95],"comparative":[3],"study":[4],"the":[6,43,49,55,62,70,81,92,103,106,113,118,135,142],"influence":[7],"doxorubicine":[9],"(DOX)":[10],"and":[11,17,34,47,75,132,140],"dehydroepiandrosterone":[12],"(DHEA)":[13],"on":[14],"cell":[15,40,84],"proliferation":[16],"oxidative":[18],"stress":[19],"in":[20,54,80,91,100],"Saccharomyces":[21],"cerevisiae":[22],"cells":[23,129],"are":[24],"presented.":[25],"Three":[26],"treatment":[27,64,114,127],"schedules":[28],"were":[29],"assessed--DOX":[30],"only,":[31,33],"DHEA":[32,68,86,133],"DOX":[35,66,116,131],"simultaneously":[36],"with":[37,65,115],"DHEA--in":[38],"examining":[39],"proliferation,":[41],"measuring":[42],"content":[44,93],"glutathione,":[46],"evaluating":[48],"expression":[50,71],"ribonucleotide":[52,73],"reductase":[53,74],"test":[56],"cells.":[57],"The":[58,125],"results":[59],"indicate":[60],"that":[61],"separate":[63],"or":[67],"stimulates":[69],"leads":[76],"to":[77],"decrease":[79,90],"rate":[82],"proliferation.":[85],"produces":[87],"dose-dependent":[89],"reduced":[96],"form":[97,108],"glutathione":[99,139],"cells,":[101],"whereas":[102],"concentration":[104],"oxidized":[107],"remains":[109],"unchanged.":[110],"In":[111],"contrast,":[112],"increased":[117,134],"concentrations":[119],"both":[121],"forms":[122],"glutathione.":[124],"simultaneous":[126],"by":[130],"accumulation":[136],"intracellular":[138],"decreased":[141],"total":[143],"antiproliferative":[144],"effect.":[145]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}