{"id":"https://openalex.org/W2396508951","doi":null,"title":"[Features of carcinogenesis and aging in knockout male mice PARP-1].","display_name":"[Features of carcinogenesis and aging in knockout male mice PARP-1].","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2396508951","mag":"2396508951","pmid":"https://pubmed.ncbi.nlm.nih.gov/20804055"},"language":"ru","primary_location":{"id":"pmid:20804055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20804055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Voprosy onkologii","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010773359","display_name":"Piskunova Ts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T S Piskunova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754634","display_name":"M A Zabezhinski\u012d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Zabezhinski\u012d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029926107","display_name":"Irina G. Popovich","orcid":"https://orcid.org/0000-0002-9937-025X","observed_orcids":["https://orcid.org/0000-0002-9937-025X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I G Popovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002580677","display_name":"Anna V. Semenchenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A V Semenchenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103513578","display_name":"Irina G. Kovalenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I G Kovalenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110725417","display_name":"\u041f\u043e\u0440\u043e\u0448\u0438\u043d\u0430 \u0422\u0430\u0442\u044c\u044f\u043d\u0430 \u0415\u0432\u0433\u0435\u043d\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-5558-5366","observed_orcids":["https://orcid.org/0000-0001-5558-5366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T E Poroshina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112169575","display_name":"Tyndyk Ml","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Tyndyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109261726","display_name":"Vladimir N. Anisimov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V N Anisimov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21986755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"3","first_page":"321","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8130000233650208},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7509999871253967},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tumor-latency","display_name":"tumor latency","score":0.8669999837875366},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.6679999828338623},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.8367117643356323},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.7313866019248962},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.6307613253593445},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.5648674964904785},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.4916275143623352},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4856499433517456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4731517732143402},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4399428367614746},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4355491101741791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40127646923065186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36784470081329346},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34034067392349243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2894805669784546},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.27688509225845337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2527855336666107},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24307963252067566},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.23078903555870056},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20804055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20804055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Voprosy onkologii","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049977607","https://openalex.org/W7095812665","https://openalex.org/W2411990784","https://openalex.org/W2073732302","https://openalex.org/W2305762476","https://openalex.org/W1989599224","https://openalex.org/W2090747311","https://openalex.org/W2413532049","https://openalex.org/W2101274152","https://openalex.org/W2002433066"],"abstract_inverted_index":{"Poly(ADP-ribosyl)ation":[0],"polymerase-1":[1],"(PARP-1)":[2],"is":[3],"a":[4],"major":[5],"factor":[6],"of":[7,51,65,93,116,127,141],"DNA":[8,142],"repair.":[9],"Age-related":[10],"parameters":[11],"such":[12],"as":[13,27,57,59,131],"body":[14],"weight":[15],"and":[16,39,70,77,97,103,106,124,146],"blood":[17],"cholesterol":[18],"in":[19,60,68,144],"knockout":[20,69],"male":[21],"mice":[22,61,72,110,134],"PARP-1":[23],"were":[24,91],"more":[25],"pronounced":[26],"compared":[28,132],"with":[29,133],"controls.":[30],"Mean":[31,63],"life":[32,120],"span":[33],"was":[34,54,73],"shorter":[35,119],"(486":[36],"+/-":[37,41,75,79],"31.7":[38],"723":[40],"22.6":[42],"days,":[43,81],"respectively,":[44,82],"(p":[45,83,100],"=":[46,101],"0.000005)":[47],"while":[48],"initial":[49],"risk":[50],"death":[52],"(beta)":[53],"8":[55],"times":[56],"high":[58],"PARP-1(+/+).":[62,135],"latency":[64],"all":[66],"tumors":[67,92],"control":[71],"656":[74],"43.5":[76],"782":[78],"33.8":[80],"<":[84],"0.05).":[85],"Among":[86],"the":[87,94,139],"most":[88],"frequent":[89],"neoplasms":[90],"liver":[95,128],"(experimental--22%":[96],"control--8%,":[98],"respectively)":[99],"0.03)":[102],"lungs":[104],"(8%":[105],"12%,":[107],"respectively).":[108],"Hence,":[109],"PARP-1(-/-)":[111],"revealed":[112],"certain":[113],"typical":[114],"charhacteristics":[115],"accelerated":[117],"aging,":[118],"span,":[121],"earlier":[122],"carcinogenesis":[123,145],"higher":[125],"rates":[126],"tumor":[129],"incidence":[130],"Our":[136],"evidence":[137],"highlights":[138],"role":[140],"repair":[143],"aging.":[147]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}