{"id":"https://openalex.org/W2396414156","doi":null,"title":"99mTc-Labeled anti-receptor for advanced glycation endproducts monoclonal antibody F(ab\u2019)2 fragments","display_name":"99mTc-Labeled anti-receptor for advanced glycation endproducts monoclonal antibody F(ab\u2019)2 fragments","publication_year":2010,"publication_date":"2010-08-16","ids":{"openalex":"https://openalex.org/W2396414156","mag":"2396414156"},"language":"en","primary_location":{"id":"mag:2396414156","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/20734504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027369782","display_name":"Liang Shan","orcid":"https://orcid.org/0000-0002-8833-2514","observed_orcids":["https://orcid.org/0000-0002-8833-2514"]},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liang Shan","raw_affiliation_strings":["National Center for Biotechnology Information, NLM, NIH"],"raw_orcid":"https://orcid.org/0000-0002-8833-2514","affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, NLM, NIH","institution_ids":["https://openalex.org/I4210109390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027369782"],"corresponding_institution_ids":["https://openalex.org/I4210109390"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f-ab-2-fragments","display_name":"F(ab')2 fragments","score":0.8650000095367432},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9559999704360962},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.949999988079071},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-imaging","display_name":"atherosclerotic plaque imaging","score":0.8790000081062317},{"id":"https://openalex.org/keywords/spect-imaging","display_name":"SPECT imaging","score":0.7829999923706055},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3009999990463257},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.38999998569488525},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.609000027179718},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.4740000069141388},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.382999986410141},{"id":"https://openalex.org/keywords/inflammation-imaging","display_name":"inflammation imaging","score":0.3790000081062317},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.882696270942688},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8472808599472046},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6059461236000061},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.6007118225097656},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.5398975610733032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5304065942764282},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4899367690086365},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4427797794342041},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4272240400314331},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.364197701215744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3511900305747986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33832815289497375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3092811703681946},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27778303623199463},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06955301761627197}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2396414156","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/20734504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1965914404","https://openalex.org/W1967839371","https://openalex.org/W2026597856","https://openalex.org/W2054082659","https://openalex.org/W2075890859","https://openalex.org/W2076619655","https://openalex.org/W2110278814","https://openalex.org/W2118046722","https://openalex.org/W2127620487","https://openalex.org/W2143716620"],"related_works":["https://openalex.org/W2110278814","https://openalex.org/W2075890859","https://openalex.org/W4388417963","https://openalex.org/W3030789089","https://openalex.org/W4256533313","https://openalex.org/W131595916","https://openalex.org/W2030825396","https://openalex.org/W4384921388","https://openalex.org/W2220691751","https://openalex.org/W2907148443"],"abstract_inverted_index":{"The":[0,70,131,184,206,294,397,441],"99mTc-labeled":[1,338],"anti-receptor":[2],"for":[3,27,81,140,247,286],"advanced":[4,132],"glycation":[5,133],"endproducts":[6,134],"(RAGE)":[7],"monoclonal":[8,388,399],"antibody":[9,340,389,400],"F(ab\u2019)2":[10,341,409],"fragment,":[11],"abbreviated":[12],"as":[13,179,328],"99mTc-anti-RAGE":[14,17,417,447],"mF(ab\u2019)2":[15,448],"or":[16],"F(ab\u2019)2,":[18],"is":[19,44,79,99,115,162,240,278],"a":[20,45,105,110,119,144,171,271,312,329,337,365,387,434],"radiotracer":[21,416,424],"developed":[22,336,386],"by":[23,31,210],"Tekabe":[24,333,383],"et":[25,334,384],"al.":[26,335,385],"imaging":[28,363,420],"atherosclerotic":[29,292,304,355],"lesions":[30,428],"targeting":[32],"highly":[33,116],"expressed":[34,100,117,279],"RAGE":[35,43,85,98,114,189,276,321,344,395],"with":[36,360,379,404,446],"single-photon":[37],"emission":[38],"computed":[39],"tomography":[40],"(SPECT)":[41],"(1).":[42,396,463],"35-kDa":[46],"transmembrane":[47,64],"receptor":[48],"of":[49,74,107,121,147,160,194,236,258,291,315,320,331,350,394],"the":[50,137,211,237,256,287,317,351,354,375,380,391,407,415,423],"immunoglobulin":[51],"(Ig)":[52],"superfamily":[53],"(2,":[54,181],"3).RAGE":[55],"has":[56],"one":[57,63,67],"V":[58,71],"domain,":[59,65],"two":[60,75],"C":[61],"domains,":[62],"and":[66,78,92,123,128,149,166,168,188,196,198,227,249,252,266,289,302,307,325,345,406,459],"cytoplasmic":[68],"tail.":[69],"domain":[72,393],"consists":[73],"N-glycosylation":[76],"sites":[77],"responsible":[80],"extracellular":[82,392],"ligand":[83],"binding.":[84],"exists":[86],"in":[87,104,109,118,200,263,274,280,353,364,429,438,456,461],"three":[88],"forms:":[89],"full-length,":[90],"membrane-bound,":[91],"soluble":[93],"(2-4).":[94],"Under":[95],"physiological":[96],"conditions,":[97,268],"at":[101],"low":[102],"levels":[103],"variety":[106],"cells":[108,195],"regulated":[111],"manner,":[112],"but":[113,269],"series":[120],"age-":[122,248],"diabetes-related":[124,250],"chronic":[125],"inflammatory":[126],"diseases":[127],"cancer":[129,253],"(5-8).":[130],"(AGEs)":[135],"are":[136,143,261],"major":[138],"ligands":[139],"RAGE.":[141],"AGEs":[142,161,187,260],"heterogeneous":[145],"group":[146],"peptides":[148],"proteins":[150],"derived":[151],"from":[152],"non-enzymatic":[153],"glycosylation":[154],"processes":[155],"(3,":[156],"5).":[157],"Large":[158],"amounts":[159],"formed":[163,262],"through":[164],"metabolism":[165],"aging,":[167],"this":[169],"establishes":[170],"positive":[172],"feedback":[173],"cycle":[174],"under":[175],"pathological":[176,207],"conditions":[177,251],"such":[178],"diabetes":[180],"4,":[182],"9).":[183,310],"interaction":[185,213,239,296],"between":[186],"affects":[190],"almost":[191],"all":[192,282],"types":[193,284],"molecules":[197],"results":[199,442],"pro-inflammatory":[201],"gene":[202],"activation":[203],"(8,":[204,309],"10).":[205],"effects":[208],"induced":[209],"AGEs/RAGE":[212,238,295],"include":[214],"increasing":[215],"vascular":[216,219,300],"permeability,":[217],"inhibiting":[218],"dilation,":[220],"inducing":[221],"cytokine":[222],"secretion,":[223],"enhancing":[224],"oxidative":[225],"stress,":[226],"modulating":[228],"cell":[229,283],"response":[230],"to":[231,242,270,298,413,433,452],"exogenous":[232],"growth":[233],"factors.":[234],"Understanding":[235],"crucial":[241],"develop":[243],"new":[244],"treatment":[245],"regimens":[246],"(4,":[254],"10).In":[255],"case":[257],"atherosclerosis,":[259,332],"both":[264],"diabetic":[265,299,430],"nondiabetic":[267,366,439],"greater":[272],"extent":[273],"diabetes.":[275],"itself":[277],"nearly":[281],"pertinent":[285],"development":[288,306],"progression":[290,308],"plaque.":[293],"leads":[297],"complications":[301],"augments":[303],"plaque":[305],"In":[311],"proof-of-concept":[313],"study":[314],"whether":[316],"expression":[318],"level":[319],"could":[322,357],"be":[323,358,450],"detected":[324],"thus":[326],"used":[327,451],"marker":[330],"polyclonal":[339,381],"fragment":[342,352,410],"against":[343,390],"further":[346],"demonstrated":[347],"that":[348,422,444],"uptake":[349],"plaques":[356],"visualized":[359],"planar":[361],"\u03b3":[362],"apolipoprotein":[367],"E\u2013null":[368],"(ApoE\u2013/\u2013)":[369],"mouse":[370],"model":[371],"(2).":[372],"To":[373],"reduce":[374],"nonspecific":[376],"binding":[377],"associated":[378],"antibody,":[382],"intact":[398],"was":[401,411],"then":[402],"digested":[403],"pepsin,":[405],"generated":[408],"radiolabeled":[412],"produce":[414],"mF(ab\u2019)2.":[418],"SPECT":[419,445],"showed":[421],"identified":[425],"early":[426],"accelerated":[427],"ApoE\u2013/\u2013":[431],"mice":[432],"better":[435],"degree":[436],"than":[437],"mice.":[440],"indicated":[443],"may":[449],"assess":[453],"novel":[454],"therapies":[455],"experimental":[457],"animals":[458],"possibly":[460],"humans":[462]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}