{"id":"https://openalex.org/W2396237604","doi":"https://doi.org/10.1177/039139888600900313","title":"Preparation of Small Volume, Leuko and Erythrocyte Very Poor Platelet Concentrates","display_name":"Preparation of Small Volume, Leuko and Erythrocyte Very Poor Platelet Concentrates","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W2396237604","doi":"https://doi.org/10.1177/039139888600900313","mag":"2396237604","pmid":"https://pubmed.ncbi.nlm.nih.gov/3733246"},"language":"en","primary_location":{"id":"doi:10.1177/039139888600900313","doi":"https://doi.org/10.1177/039139888600900313","is_oa":false,"landing_page_url":"https://doi.org/10.1177/039139888600900313","pdf_url":null,"source":{"id":"https://openalex.org/S10751480","display_name":"The International Journal of Artificial Organs","issn_l":"0391-3988","issn":["0391-3988","1724-6040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Artificial Organs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081518269","display_name":"Mauro Valbonesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Valbonesi","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Angelini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Angelini","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050494803","display_name":"Libera Malfanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Malfanti","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024938551","display_name":"Giuseppe Lercari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Lercari","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066869718","display_name":"Mauro Fella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Fella","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078755830","display_name":"S. Calderisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Calderisi","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Anselmo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Anselmo","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057887393","display_name":"Maria Balistreri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Balistreri","raw_affiliation_strings":["Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology Services-Hemophilia Center, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210146472"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21931736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"3","first_page":"189","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukocyte-contamination","display_name":"leukocyte contamination","score":0.777999997138977},{"id":"https://openalex.org/keywords/red-blood-cell-contamination","display_name":"red blood cell contamination","score":0.8960000276565552},{"id":"https://openalex.org/keywords/platelet-yield","display_name":"platelet yield","score":0.7850000262260437},{"id":"https://openalex.org/keywords/plasma-volume-loss","display_name":"plasma volume loss","score":0.5239999890327454},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.5630000233650208},{"id":"https://openalex.org/keywords/ristocetin-induced-platelet-aggregation","display_name":"ristocetin-induced platelet aggregation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7898393869400024},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6336547136306763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6140730977058411},{"id":"https://openalex.org/C2780657338","wikidata":"https://www.wikidata.org/wiki/Q191134","display_name":"Centrifuge","level":2,"score":0.5582566857337952},{"id":"https://openalex.org/C2991747820","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Plasma volume","level":2,"score":0.516758143901825},{"id":"https://openalex.org/C2778285947","wikidata":"https://www.wikidata.org/wiki/Q548079","display_name":"Buffy coat","level":2,"score":0.5110520124435425},{"id":"https://openalex.org/C7623868","wikidata":"https://www.wikidata.org/wiki/Q1967135","display_name":"Centrifugation","level":2,"score":0.5029680132865906},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4567834138870239},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4445386230945587},{"id":"https://openalex.org/C185004128","wikidata":"https://www.wikidata.org/wiki/Q3011536","display_name":"Separator (oil production)","level":2,"score":0.4420742392539978},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.41870272159576416},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35621851682662964},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24882426857948303},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23779815435409546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15269550681114197},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1183747947216034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11386704444885254},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10511168837547302},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002498","descriptor_name":"Centrifugation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004906","descriptor_name":"Erythrocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010983","descriptor_name":"Plateletpheresis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/039139888600900313","doi":"https://doi.org/10.1177/039139888600900313","is_oa":false,"landing_page_url":"https://doi.org/10.1177/039139888600900313","pdf_url":null,"source":{"id":"https://openalex.org/S10751480","display_name":"The International Journal of Artificial Organs","issn_l":"0391-3988","issn":["0391-3988","1724-6040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Artificial Organs","raw_type":"journal-article"},{"id":"pmid:3733246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3733246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of artificial organs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1967736279","https://openalex.org/W1991186452","https://openalex.org/W1999881744","https://openalex.org/W2087482644","https://openalex.org/W2102166551","https://openalex.org/W2173711581","https://openalex.org/W4210357961"],"related_works":["https://openalex.org/W2030954883","https://openalex.org/W2088444469","https://openalex.org/W2075516936","https://openalex.org/W2134804506","https://openalex.org/W2000895569","https://openalex.org/W2077678228","https://openalex.org/W2095029268","https://openalex.org/W4386366043","https://openalex.org/W1999176581","https://openalex.org/W2087818644"],"abstract_inverted_index":{"Recently":[0,174],"developed":[1,82,175,350],"automated":[2,176],"discontinuous":[3,248],"flow":[4,249],"centrifuge":[5,250],"(DFC)":[6,251],"separators":[7,178],"can":[8,179],"produce":[9,47,180,356],"leuko-":[10],"and":[11,79,90,137,151,183,206,227,283,313,333,336,360],"erythrocyte-poor":[12],"platelet":[13,120,168,306],"concentrates":[14,169],"(PC).":[15],"According":[16],"to":[17,26,46,195,320,355],"general":[18],"experience":[19],"with":[20,75,117,255,302,351],"these":[21,189],"machines":[22,190],"it":[23,191],"is":[24,171],"difficult":[25,194],"obtain":[27,196],"more":[28],"than":[29,208],"4":[30,201],"\u00d7":[31,52,124,132,141,202,210,268,289],"10":[32,53,125,133,142,203,211,269,290],"11":[33,54,126,204,270],"platelets,":[34],"though":[35],"a":[36,58,69,80,118,246,274,348],"second":[37],"program":[38,241],"set":[39],"up":[40],"by":[41,156,285,310],"Coffe":[42],"et":[43],"al.":[44],"appears":[45],"PC":[48,112,158,197,264,299],"containing":[49,198,265],"approximately":[50],"5":[51],"platelets":[55,205,271],"suspended":[56,272],"in":[57,273],"plasma":[59,229,282],"volume":[60,110,146],"of":[61,86,111,122,233,239,276,281,297,305,325,331,340],"390":[62],"ml.":[63],"At":[64,243],"our":[65,244,317],"center":[66,245],"we":[67,98,345],"employed":[68],"new":[70],"Dideco":[71],"cell":[72,177,252],"separator":[73,253],"equipped":[74,254],"the":[76,84,100,160,237,240,256,298,322,326,329,337,352],"surge":[77,257],"pump":[78,258],"technique":[81,349],"for":[83,165,236],"production":[85],"small":[87,357],"volume,":[88,358],"RBC":[89,138,152,334],"WBC-very":[91],"poor":[92,186,362],"PC.":[93,187,363],"In":[94,342],"60":[95],"routine":[96],"procedures":[97],"obtained":[99],"following":[101],"results:":[102],"mean":[103,119,275],"processing":[104],"time":[105],"87":[106],"\u00b111":[107],"minutes;":[108],"final":[109],"136":[113],"\u00b1":[114,278,287],"19":[115],"ml,":[116],"yield":[121],"5.21":[123],"platelets.":[127],"WBC":[128,150,292,332,359],"contamination":[129,153,335],"was":[130,259,300],"1.8":[131],"8":[134,143],"(93%":[135],"lymphocytes)":[136],"were":[139,154],"3.1":[140],".":[144],"Plasma":[145],"as":[147,149,221,308],"well":[148],"reduced":[155],"recirculating":[157],"after":[159],"6th":[161],"pass.":[162],"The":[163,295],"demand":[164],"single":[166],"donor":[167,218],"(PC)":[170],"increasing":[172],"progressively.":[173],"leukocyte":[181],"(WBC)":[182],"erythrocyte":[184],"(RBC)":[185],"With":[188],"may":[192],"be":[193],"at":[199],"least":[200],"less":[207],"1":[209],"9":[212,291],"leukocytes":[213],"(1,":[214],"2,":[215],"3)":[216],"since":[217],"variables":[219],"such":[220],"hematocrit,":[222],"precounts,":[223],"buffy":[224],"coat":[225],"formation":[226],"initial":[228],"light":[230,321],"transmission":[231],"are":[232],"paramount":[234],"importance":[235],"efficiency":[238],"(3).":[242],"prototype":[247,354],"studied":[260],"(4).":[261],"It":[262],"produced":[263],"3.58":[266],"\u00b11.5":[267],"346.32":[277],"51.7":[279],"ml":[280],"contaminated":[284],"0.63":[286],"0.51":[288],"(95%":[293],"lymphocytes).":[294],"quality":[296],"satisfactory,":[301],"good":[303],"maintenance":[304],"functions":[307],"measured":[309],"ristocetin-induced":[311],"aggregation":[312],"malonaldehyde":[314],"production,":[315],"but":[316],"study":[318,344],"brought":[319],"main":[323],"limitations":[324],"system,":[327],"namely":[328],"variability":[330],"excessive":[338],"loss":[339],"plasma.":[341],"this":[343],"report":[346],"on":[347],"Unicell":[353],"RBC-very":[361]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}