{"id":"https://openalex.org/W2396196877","doi":null,"title":"The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell.","display_name":"The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell.","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W2396196877","mag":"2396196877","pmid":"https://pubmed.ncbi.nlm.nih.gov/7005051"},"language":"en","primary_location":{"id":"pmid:7005051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7005051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research. Supplement series","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006599396","display_name":"Illani J. Atwater","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Atwater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108444719","display_name":"C M Dawson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M Dawson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112117441","display_name":"Angela M. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022128774","display_name":"Geoffrey T. Eddlestone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Eddlestone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109887919","display_name":"E Rojas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Rojas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3697,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.87856218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"Suppl 10","issue":null,"first_page":"100","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/electrical-activity","display_name":"electrical activity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/burst-firing","display_name":"burst firing","score":0.460999995470047},{"id":"https://openalex.org/keywords/oscillations","display_name":"oscillations","score":0.4970000088214874},{"id":"https://openalex.org/keywords/calcium-activated-potassium-channels","display_name":"calcium-activated potassium channels","score":0.49000000953674316},{"id":"https://openalex.org/keywords/quinine","display_name":"quinine","score":0.878000020980835},{"id":"https://openalex.org/keywords/calcium-permeability","display_name":"calcium permeability","score":0.6439999938011169},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.6019999980926514},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.847000002861023},{"id":"https://openalex.org/keywords/potassium-levels","display_name":"potassium concentration","score":0.5950000286102295},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.4690000116825104},{"id":"https://openalex.org/keywords/mouse-islets","display_name":"mouse islets","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.8105512857437134},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.672042965888977},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6672878265380859},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.6511939167976379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5276502370834351},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4994797706604004},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.4835936427116394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47836703062057495},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.47326019406318665},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.47291502356529236},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.46949461102485657},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.45040422677993774},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.44641411304473877},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3051472306251526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24604421854019165},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.24127301573753357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1878502070903778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12250977754592896},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011803","descriptor_name":"Quinine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7005051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7005051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research. Supplement series","raw_type":"Journal Article"},{"id":"mag:2396196877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7005051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1548039665","https://openalex.org/W2082358964","https://openalex.org/W2430565266","https://openalex.org/W2044187333","https://openalex.org/W2086944507","https://openalex.org/W2055727632","https://openalex.org/W1968599975","https://openalex.org/W2443412354","https://openalex.org/W2340855943","https://openalex.org/W7096502809"],"abstract_inverted_index":{"The":[0,47,180],"typical":[1],"burst":[2],"pattern":[3],"of":[4,10,16,28,33,39,74,96,105,113,151,161,175],"electrical":[5,118],"activity":[6,119],"recorded":[7],"from":[8,23,124],"beta-cells":[9],"mouse":[11,126],"islets":[12],"in":[13,26,110,149,172,183],"the":[14,34,40,71,75,94,97,102,106,111,143,146,162,173,186],"presence":[15],"11.1":[17],"mM":[18],"glucose":[19],"has":[20,139],"been":[21,140],"compared":[22],"225":[24],"cells":[25],"terms":[27,150],"two":[29,48],"parameters:":[30],"relative":[31,72,103],"duration":[32,73,104],"active":[35,43,76,107],"phase":[36,77],"and":[37,44,54,117,120,130,165,200],"periodicity":[38,58],"oscillations":[41],"between":[42,155],"silent":[45],"phases.":[46],"parameters":[49],"show":[50],"different":[51],"distributions,":[52],"Gaussian":[53],"bimodal":[55],"respectively.":[56],"Burst":[57],"was":[59,78],"found":[60],"to":[61],"increase":[62,171],"dramatically":[63],"at":[64,81],"external":[65,89],"potassium":[66,166,191],"concentrations":[67,82],"below":[68],"2mM,":[69],"while":[70],"little":[79],"affected":[80],"as":[83,85],"low":[84],"0.5":[86],"mM.":[87],"Increasing":[88],"calcium":[90,156,178],"concentration":[91,174],"significantly":[92],"increased":[93],"amplitude":[95],"bursts":[98],"but":[99],"greatly":[100],"decreased":[101],"phase.":[108],"Quinine,":[109],"absence":[112],"glucose,":[114],"induced":[115],"depolarization":[116,160],"stimulated":[121],"insulin":[122,131,201],"release":[123,132],"perifused":[125],"islets;":[127],"spike":[128],"frequency":[129],"followed":[133],"a":[134,152,189],"monophasic":[135],"pattern.":[136],"A":[137],"model":[138],"proposed":[141],"for":[142],"beta-cell":[144],"explaining":[145],"experimental":[147],"results":[148,181],"feedback":[153],"mechanism":[154],"permeability":[157,167],"activated":[158,168],"by":[159,169,195],"cell":[163],"membrane":[164,198],"an":[170],"intracellular":[176],"ionized":[177],"[Ca2+]i.":[179],"are":[182],"agreement":[184],"with":[185],"hypothesis":[187],"that":[188],"[Ca2+]i-dependent":[190],"permeability,":[192],"specifically":[193],"blocked":[194],"quinine,":[196],"controls":[197],"potential":[199],"release.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
