{"id":"https://openalex.org/W2396148708","doi":null,"title":"Hot-flashes in breast cancer survivors: effectiveness of low-dosage fluoxetine. A pilot study.","display_name":"Hot-flashes in breast cancer survivors: effectiveness of low-dosage fluoxetine. A pilot study.","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2396148708","mag":"2396148708","pmid":"https://pubmed.ncbi.nlm.nih.gov/16270523"},"language":"en","primary_location":{"id":"pmid:16270523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16270523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090715927","display_name":"Luigi Mariani","orcid":"https://orcid.org/0000-0001-6208-4084","observed_orcids":["https://orcid.org/0000-0001-6208-4084","https://orcid.org/0000-0002-1971-5095"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Mariani","raw_affiliation_strings":["Dept. of Gynecologic Oncology, Regina Elena National Cancer Institute of Rome, Rome, Italy. luciorm@libero.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Gynecologic Oncology, Regina Elena National Cancer Institute of Rome, Rome, Italy. luciorm@libero.it","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Quattrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Quattrini","raw_affiliation_strings":["Istituto Nazionale Tumori Regina Elena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori Regina Elena","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026463431","display_name":"Marco Atlante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Atlante","raw_affiliation_strings":["Istituto Nazionale Tumori Regina Elena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori Regina Elena","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Galati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Galati","raw_affiliation_strings":["Istituto Regina Elena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Regina Elena","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017588854","display_name":"Antonella Barbati","orcid":"https://orcid.org/0000-0002-8774-8956","observed_orcids":["https://orcid.org/0000-0002-8774-8956"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Barbati","raw_affiliation_strings":["University of Perugia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Perugia","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086743021","display_name":"Diana Giannarelli","orcid":"https://orcid.org/0000-0002-6085-1195","observed_orcids":["https://orcid.org/0000-0002-6085-1195"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Giannarelli","raw_affiliation_strings":["Istituto Regina Elena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Regina Elena","institution_ids":["https://openalex.org/I4387152244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1663,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56254688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"3","first_page":"373","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/breast-cancer-survivors","display_name":"breast cancer survivors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vasomotor-symptoms","display_name":"vasomotor symptoms","score":0.9900000095367432},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8930000066757202},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.5289999842643738},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.8731800317764282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7983616590499878},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.692131519317627},{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.5925332903862},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5877536535263062},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5233330130577087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4981555938720703},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4547197222709656},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.436451256275177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3870645761489868},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38702404499053955},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019584","descriptor_name":"Hot Flashes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16270523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16270523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Clinical Trial"},{"id":"mag:2396148708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16270523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2111093019","https://openalex.org/W1973757681","https://openalex.org/W2075331084","https://openalex.org/W2107117826","https://openalex.org/W2119945022","https://openalex.org/W1865738444","https://openalex.org/W2099390608","https://openalex.org/W1977155028","https://openalex.org/W2133675074","https://openalex.org/W2058646840"],"abstract_inverted_index":{"Breast":[0],"carcinoma":[1],"survivors":[2],"suffering":[3],"from":[4],"hot-flashes":[5,76,82],"experience":[6],"a":[7,35,66],"negative":[8],"impact":[9],"on":[10],"their":[11],"quality":[12],"of":[13,41,64,70,74,100],"life.":[14],"Antidepressants":[15],"have":[16],"recently":[17],"been":[18,89],"proven":[19],"to":[20,50,93],"be":[21,113],"effective":[22],"in":[23,33,103],"these":[24,104,116],"women,":[25],"significantly":[26],"reducing":[27],"the":[28,57,62,71,94,98],"vasomotor":[29],"symptoms.":[30],"With":[31],"this":[32],"mind,":[34],"single-arm":[36],"clinical":[37],"trial":[38],"low-dose":[39],"regimen":[40],"Fluoxetine":[42,101],"(10":[43],"mg/day":[44],"for":[45],"4":[46],"weeks)":[47],"was":[48,106],"given":[49],"twenty":[51],"symptomatic":[52],"breast":[53],"cancer":[54],"patients.":[55],"Among":[56],"12":[58],"women":[59],"evaluated":[60],"at":[61],"end":[63],"treatment,":[65],"statistically":[67],"significant":[68],"reduction":[69],"mean":[72],"number":[73],"daily":[75],"(-36.3%,":[77],"p":[78,85],"=":[79,86],"0.001)":[80],"and":[81],"score":[83],"(-46.2%,":[84],"0.0006)":[87],"had":[88],"detected":[90],"as":[91],"compared":[92],"baseline":[95],"data.":[96],"Although":[97],"dosage":[99],"used":[102],"trials":[105],"lower":[107],"than":[108],"earlier":[109],"published,":[110],"it":[111],"should":[112],"noted":[114],"that":[115],"positive":[117],"results":[118],"were":[119],"achieved":[120],"without":[121],"any":[122],"relevant":[123],"side":[124],"effects.":[125]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}