{"id":"https://openalex.org/W2396068152","doi":"https://doi.org/10.1152/ajprenal.1997.273.3.f463","title":"EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney","display_name":"EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2396068152","doi":"https://doi.org/10.1152/ajprenal.1997.273.3.f463","mag":"2396068152","pmid":"https://pubmed.ncbi.nlm.nih.gov/9321921"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1997.273.3.f463","doi":"https://doi.org/10.1152/ajprenal.1997.273.3.f463","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1997.273.3.f463","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H. Sakurai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Sakurai","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076893733","display_name":"Tatsuo Tsukamoto","orcid":"https://orcid.org/0000-0003-2896-5595","observed_orcids":["https://orcid.org/0000-0003-2896-5595"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Tsukamoto","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069326153","display_name":"Crystal Kjelsberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Kjelsberg","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. G. Cantley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. G. Cantley","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022684460","display_name":"Sanjay K. Nig\u00e1m","orcid":"https://orcid.org/0000-0003-0757-3066","observed_orcids":["https://orcid.org/0000-0003-0757-3066"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. K. Nigam","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston,Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":3.6266,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.9289012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"273","issue":"3","first_page":"F463","last_page":"F472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egf-receptor-ligands","display_name":"EGF receptor ligands","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9020000100135803},{"id":"https://openalex.org/keywords/embryonic-kidney","display_name":"embryonic kidney","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mimcd3-cells","display_name":"mIMCD3 cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.7129999995231628},{"id":"https://openalex.org/keywords/urokinase-receptor","display_name":"urokinase receptor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heparin-binding-egf","display_name":"heparin-binding EGF","score":0.8519999980926514},{"id":"https://openalex.org/keywords/betacellulin","display_name":"betacellulin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/amphiregulin","display_name":"amphiregulin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.8090000152587891},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.7896198630332947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6302220821380615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6218255162239075},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.6100111603736877},{"id":"https://openalex.org/C2780806702","wikidata":"https://www.wikidata.org/wiki/Q14866198","display_name":"Amphiregulin","level":4,"score":0.5904995203018188},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5751394629478455},{"id":"https://openalex.org/C130010870","wikidata":"https://www.wikidata.org/wiki/Q2500532","display_name":"Ureteric bud","level":5,"score":0.5200130939483643},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.4323660135269165},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.43024975061416626},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.38784974813461304},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3471672236919403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34630143642425537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3407529592514038},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33034801483154297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12341555953025818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07445278763771057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004627","descriptor_name":"Embryonic Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010618","descriptor_name":"Phenanthrolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.1997.273.3.f463","doi":"https://doi.org/10.1152/ajprenal.1997.273.3.f463","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1997.273.3.f463","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:9321921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9321921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5181715228","display_name":"SIGNAL TRANSDUCTION BY THE C-MET RECEPTOR","funder_award_id":"R01DK048871","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023586869","https://openalex.org/W2110278880","https://openalex.org/W2038409050","https://openalex.org/W2252983407","https://openalex.org/W2022422012","https://openalex.org/W1985218254","https://openalex.org/W2083535082","https://openalex.org/W2166001167","https://openalex.org/W2306558186","https://openalex.org/W2032002630"],"abstract_inverted_index":{"Much":[0],"attention":[1],"has":[2],"recently":[3],"focused":[4],"upon":[5],"hepatocyte":[6],"growth":[7,91,190,233],"factor":[8,92],"(HGF)":[9],"as":[10],"a":[11,80,119,130],"potential":[12],"regulator":[13],"of":[14,39,114,133,205],"epithelial":[15,61,148],"branching":[16,30,44,107,134,178,237],"morphogenesis.":[17],"However,":[18],"since":[19],"neither":[20],"the":[21,36,52,74,89,138,159,218,225],"HGF":[22,40,173],"nor":[23],"c-met":[24,153,163],"\"knockout\"":[25],"mice":[26,155],"show":[27],"abnormal":[28],"kidney":[29,60,140],"morphogenesis,":[31],"we":[32,77],"sought":[33],"to":[34,176],"analyze":[35],"relative":[37],"importance":[38],"in":[41,42,70,106,180],"vitro":[43],"morphogenesis":[45],"compared":[46],"with":[47,73,158],"other":[48],"factors":[49],"secreted":[50,136],"by":[51,109,137,217],"embryonic":[53,75,139,147,160],"kidney.":[54],"Exploiting":[55],"an":[56,146],"assay":[57],"that":[58,79,84,125,227],"employs":[59],"cells":[62,165],"(murine":[63],"inner":[64],"medullary":[65],"collecting":[66],"duct,":[67],"mIMCD3)":[68],"seeded":[69],"collagen":[71],"cocultured":[72,157],"kidney,":[76,161],"found":[78],"tyrosine":[81],"kinase":[82],"inhibitor":[83,220],"is":[85],"highly":[86],"specific":[87],"for":[88,129],"epidermal":[90],"(EGF)":[93],"receptor":[94],"(EGFR),":[95],"tyrphostin":[96],"AG1478,":[97],"inhibited":[98,216],"mIMCD3":[99,198],"cell":[100,149,199],"process":[101,167],"formation":[102],"(an":[103],"early":[104],"step":[105],"tubulogenesis)":[108],"40%,":[110],"whereas":[111],"high":[112],"concentrations":[113],"neutralizing":[115],"anti-HGF":[116],"antibodies":[117],"had":[118],"lesser":[120],"effect":[121],"(20%":[122],"inhibition),":[123],"suggesting":[124],"EGFR":[126,169,184,201],"ligands":[127,170,185,202],"account":[128],"larger":[131],"fraction":[132],"morphogens":[135],"than":[141],"HGF.":[142],"In":[143],"addition,":[144],"when":[145],"line":[150],"derived":[151],"from":[152],"(-/-)":[154,164],"was":[156],"these":[162,181],"underwent":[166],"formation.":[168],"but":[171],"not":[172],"were":[174],"able":[175],"induce":[177],"tubulogenesis":[179,213],"cells.":[182],"All":[183],"tested,":[186],"including":[187],"EGF,":[188,193],"transforming":[189],"factor-alpha,":[191],"heparin-binding":[192],"betacellulin,":[194],"and":[195,209,212,230],"amphiregulin,":[196],"induced":[197],"tubulogenesis.":[200,238],"caused":[203],"upregulation":[204],"urokinase,":[206],"urokinase":[207],"receptor,":[208],"matrix":[210],"metalloprotease-1,":[211],"could":[214],"be":[215],"metalloprotease":[219],"1,10-phenanthroline.":[221],"Our":[222],"results":[223],"support":[224],"notion":[226],"multiple":[228],"parallel":[229],"potentially":[231],"redundant":[232],"factor-dependent":[234],"pathways":[235],"regulate":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
