{"id":"https://openalex.org/W2396062653","doi":null,"title":"Androgens and breast cancer.","display_name":"Androgens and breast cancer.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2396062653","mag":"2396062653","pmid":"https://pubmed.ncbi.nlm.nih.gov/1551135"},"language":"en","primary_location":{"id":"pmid:1551135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer detection and prevention","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111984456","display_name":"Fernand Labrie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F Labrie","raw_affiliation_strings":["MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada","institution_ids":["https://openalex.org/I4210139308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058755438","display_name":"Jacques Simard","orcid":"https://orcid.org/0000-0001-6906-3390","observed_orcids":["https://orcid.org/0000-0001-6906-3390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Simard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077662799","display_name":"Yvan de Launoit","orcid":"https://orcid.org/0000-0003-1837-9808","observed_orcids":["https://orcid.org/0000-0003-1837-9808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y de Launoit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113767773","display_name":"R. Poulin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Poulin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Th\u00e9riault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Th\u00e9riault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058111076","display_name":"Martine Dumont","orcid":"https://orcid.org/0000-0002-5488-4839","observed_orcids":["https://orcid.org/0000-0002-5488-4839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Dumont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036519601","display_name":"Sophie Dauvois","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Dauvois","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107825354","display_name":"C\u00e9line Martel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Martel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034249927","display_name":"S M Li","orcid":"https://orcid.org/0009-0006-5199-5564","observed_orcids":["https://orcid.org/0009-0006-5199-5564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3298,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.78329734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"1","first_page":"31","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":0.9089999794960022},{"id":"https://openalex.org/keywords/zr-75-1-cells","display_name":"ZR-75-1 cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/antiestrogen-therapy","display_name":"antiestrogen therapy","score":0.6690000295639038},{"id":"https://openalex.org/keywords/gcdfp-15","display_name":"GCDFP-15","score":0.8289999961853027},{"id":"https://openalex.org/keywords/progestins","display_name":"progestins","score":0.6740000247955322},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7562257051467896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.749895453453064},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.6217286586761475},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.6156620979309082},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.580095112323761},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.43476784229278564},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.4266824722290039},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.4152846038341522},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3813502788543701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3756147623062134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35182327032089233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.309704065322876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3020671010017395},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1932935118675232},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1551135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer detection and prevention","raw_type":"Journal Article"},{"id":"mag:2396062653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1551135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033535637","https://openalex.org/W2138042394","https://openalex.org/W2076033558","https://openalex.org/W2064332615","https://openalex.org/W2155622098","https://openalex.org/W1975557160","https://openalex.org/W1971344086","https://openalex.org/W2026268878","https://openalex.org/W1629702889","https://openalex.org/W2070998674"],"abstract_inverted_index":{"We":[0,180],"have":[1,80,181],"recently":[2,183],"demonstrated":[3,184],"that":[4,71,151,168,177],"physiological":[5],"levels":[6,235],"of":[7,18,43,52,99,117,130,141,160,172,178,200,218,226],"androgens":[8,44,72,100,122,173,194,219],"exert":[9,124],"direct":[10,126],"and":[11,37,73,195,202,220,228,232,236],"potent":[12],"inhibitory":[13,41,97,127],"effects":[14,82,217],"on":[15,49,101,115,138,197,230,247],"the":[16,50,58,67,74,96,118,121,139,142,169,191,198,244],"growth":[17,51,249],"human":[19,187,211],"breast":[20,84,188],"cancer":[21,85,189],"ZR-75-1":[22,106,186,251],"cells":[23,107,190],"in":[24,26,32,57,63,83,86,104,109,185,210,250],"vivo":[25],"nude":[27],"mice":[28],"as":[29,31,163,165,222,224],"well":[30,164,223],"vitro":[33],"under":[34],"both":[35],"basal":[36],"estrogen-stimulated":[38],"conditions.":[39],"The":[40,216],"effect":[42,114,128,137],"has":[45],"also":[46,123,182],"been":[47],"confirmed":[48],"dimethylbenz(a)anthracene":[53],"(DMBA)-induced":[54],"mammary":[55],"carcinoma":[56],"rat.":[59],"Such":[60],"observations":[61,146],"are":[62,205,238],"close":[64],"agreement":[65],"with":[66],"clinical":[68,148],"data":[69,149],"showing":[70,150],"androgenic":[75,152],"compound":[76],"medroxyprogesterone":[77],"acetate":[78],"(MPA)":[79],"beneficial":[81],"women":[87],"comparable":[88],"to":[89,176,240],"other":[90],"endocrine":[91],"therapies,":[92],"including":[93],"tamoxifen.":[94],"Although":[95],"action":[98,171],"cell":[102,143,248],"proliferation":[103],"estrogen-induced":[105],"results,":[108],"part,":[110],"from":[111],"their":[112],"suppressive":[113],"expression":[116,199],"estrogen":[119],"receptor,":[120],"a":[125,134],"independent":[129],"estrogens.":[131],"Androgens":[132],"cause":[133],"global":[135],"slowing":[136],"duration":[140],"cycle.":[144],"These":[145],"support":[147],"compounds":[153],"induce":[154],"an":[155],"objective":[156],"remission":[157],"after":[158],"failure":[159],"antiestrogen":[161],"therapy":[162],"those":[166,225,241],"indicating":[167],"antiproliferative":[170],"is":[174],"additive":[175],"antiestrogens.":[179],"antagonism":[192],"between":[193],"estrogens":[196,221],"GCDFP-15":[201,231],"GCDFP-24":[203,233],"which":[204],"two":[206],"major":[207],"proteins":[208],"secreted":[209],"gross":[212],"cystic":[213],"disease":[214],"fluid.":[215],"progestins":[227],"glucocorticoids":[229],"mRNA":[234],"secretion":[237],"opposite":[239],"induced":[242],"by":[243],"same":[245],"steroids":[246],"cells.(ABSTRACT":[252],"TRUNCATED":[253],"AT":[254],"250":[255],"WORDS)":[256]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}