{"id":"https://openalex.org/W2396021784","doi":null,"title":"[New approaches to biological immunomodulation therapy of rheumatoid arthritis: neutralization of basic cytokines].","display_name":"[New approaches to biological immunomodulation therapy of rheumatoid arthritis: neutralization of basic cytokines].","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2396021784","mag":"2396021784","pmid":"https://pubmed.ncbi.nlm.nih.gov/9644739"},"language":"ru","primary_location":{"id":"pmid:9644739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9644739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049547284","display_name":"Galina V Lukina","orcid":"https://orcid.org/0000-0001-7958-5926","observed_orcids":["https://orcid.org/0000-0001-7958-5926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G V Lukina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ia A Sigidin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ia A Sigidin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072692456","display_name":"Skurkovich Sv","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S V Skurkovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054459003","display_name":"Skurkovich Bs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B S Skurkovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.2802836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"70","issue":"5","first_page":"32","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6859999895095825},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5989999771118164},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/treatment-resistant-rheumatoid-arthritis","display_name":"treatment-resistant rheumatoid arthritis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9567028284072876},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8070784211158752},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7174381613731384},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6011642217636108},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5676948428153992},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.4689202904701233},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.46575337648391724},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4628675580024719},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.45280906558036804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44812458753585815},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.44629862904548645},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.41624921560287476},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34378135204315186}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9644739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9644739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"Clinical Trial"},{"id":"mag:2396021784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9644739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2414649788","https://openalex.org/W2075100222","https://openalex.org/W2424523693","https://openalex.org/W2135718475","https://openalex.org/W3124379029","https://openalex.org/W2417200896","https://openalex.org/W2104843745","https://openalex.org/W1986474939","https://openalex.org/W2103708944","https://openalex.org/W3022421938"],"abstract_inverted_index":{"AIM:":[0],"Investigation":[1],"of":[2,4,15,22,39,44,52,87,124,130,142,185,191,195,208,211],"efficacy":[3,14],"antibodies":[5,46,104,144,162,167,186,202],"ot":[6],"interferons":[7],"in":[8,26,49,74,110,114,128,140,146,149,159,198],"rheumatoid":[9],"arthritis":[10],"(RA)":[11],"versus":[12],"relevant":[13],"the":[16,23,81,88,122,125,157,178],"tumor":[17],"necrosis":[18],"factor":[19],"(TNF),":[20],"comparison":[21],"above":[24],"cytokines":[25],"monotherapy":[27,147],"and":[28,42,59,63,71,76,148],"combined":[29,172,209],"treatment.":[30],"MATERIALS":[31],"AND":[32],"METHODS:":[33],"An":[34],"open":[35],"controlled":[36],"randomized":[37],"trial":[38],"clinical":[40],"benefit":[41],"tolerance":[43],"anticytokine":[45,103],"was":[47,73,138,156],"performed":[48],"a":[50,206],"group":[51],"RA":[53,199],"patients":[54,82,92,160,212],"at":[55],"stage":[56],"II,":[57],"III":[58,72],"IV":[60],"(1,":[61],"20":[62],"4":[64],"patients,":[65,78],"respectively).":[66],"The":[67,102,132,171],"activity":[68,117],"degree":[69],"II":[70],"10":[75],"15":[77],"respectively.":[79],"All":[80],"had":[83,174],"articular":[84],"functional":[85],"insufficiency":[86],"second":[89],"degree.":[90],"21":[91],"failed":[93],"previous":[94],"therapy":[95,210],"with":[96,151,213],"basic":[97],"drugs":[98],"including":[99],"immunodepressants.":[100],"RESULTS:":[101],"proved":[105],"to":[106,163,187],"be":[107],"highly":[108],"effective":[109],"RA.":[111,215],"Positive":[112],"changes":[113],"teh":[115],"disease":[116],"were":[118],"achieved":[119],"early":[120],"after":[121],"end":[123],"5-day":[126],"course":[127],"88%":[129],"patients.":[131],"most":[133],"definite":[134],"immediate":[135],"therapeutic":[136,183],"effect":[137,155,184],"noted":[139],"usage":[141],"TNF":[143],"both":[145],"combination":[150],"other":[152],"anticytokines.":[153],"Long-term":[154],"best":[158],"given":[161],"interferon":[164],"gamma.":[165],"Interferon-alpha":[166],"produced":[168],"weaker":[169],"effect.":[170],"treatment":[173],"no":[175],"advantages":[176],"over":[177],"monotherapy.":[179],"CONCLUSION:":[180],"A":[181],"significant":[182],"interferon-gamma":[188],"is":[189],"indicative":[190],"an":[192],"important":[193],"role":[194],"this":[196],"cytokine":[197],"pathogenesis.":[200],"Anticytokine":[201],"are":[203],"promising":[204],"as":[205],"component":[207],"resistant":[214]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
