{"id":"https://openalex.org/W2395972033","doi":"https://doi.org/10.1016/s0022-2275(20)40187-7","title":"In vivo turnover of different cholesterol esters in rat liver and plasma","display_name":"In vivo turnover of different cholesterol esters in rat liver and plasma","publication_year":1964,"publication_date":"1964-10-01","ids":{"openalex":"https://openalex.org/W2395972033","doi":"https://doi.org/10.1016/s0022-2275(20)40187-7","mag":"2395972033","pmid":"https://pubmed.ncbi.nlm.nih.gov/14221103"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)40187-7","doi":"https://doi.org/10.1016/s0022-2275(20)40187-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)40187-7","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0022-2275(20)40187-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111766091","display_name":"DeWitt S. Goodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DeWitt S. Goodman","raw_affiliation_strings":["Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, N. Y","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109869015","display_name":"Tatsuji Shiratori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatsuji Shiratori","raw_affiliation_strings":["Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, N. Y","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.7321,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.96571198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4","first_page":"578","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesteryl-esters","display_name":"cholesterol esters","score":0.9710000157356262},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4909999966621399},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cholesteryl-oleate","display_name":"cholesteryl oleate","score":0.8539999723434448},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cholesteryl-ester-hydrolysis","display_name":"cholesterol ester hydrolysis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7338668704032898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6250946521759033},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5870722532272339},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.5202001929283142},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42179951071739197},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.4124372601509094},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3893372416496277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3703337013721466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2533634901046753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11010092496871948},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.08907672762870789},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.047462016344070435}],"mesh":[{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)40187-7","doi":"https://doi.org/10.1016/s0022-2275(20)40187-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)40187-7","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:14221103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14221103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:45712259b6a44da5bdd415e4213757df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/45712259b6a44da5bdd415e4213757df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 5, Iss 4, Pp 578-586 (1964)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)40187-7","doi":"https://doi.org/10.1016/s0022-2275(20)40187-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)40187-7","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W21836373","https://openalex.org/W58524519","https://openalex.org/W63014412","https://openalex.org/W97730407","https://openalex.org/W207417193","https://openalex.org/W986616971","https://openalex.org/W1491677849","https://openalex.org/W1500243384","https://openalex.org/W1545090014","https://openalex.org/W1567966142","https://openalex.org/W1971268005","https://openalex.org/W1976409113","https://openalex.org/W1976512094","https://openalex.org/W2016856678","https://openalex.org/W2020287482","https://openalex.org/W2028715417","https://openalex.org/W2060980597","https://openalex.org/W2184365605","https://openalex.org/W2186498754","https://openalex.org/W2333232113","https://openalex.org/W2407535432","https://openalex.org/W2413630491","https://openalex.org/W3119629817"],"related_works":["https://openalex.org/W2185374596","https://openalex.org/W7098210070","https://openalex.org/W2014386443","https://openalex.org/W2085632535","https://openalex.org/W1545090014","https://openalex.org/W2002769609","https://openalex.org/W2019055375","https://openalex.org/W1504937743","https://openalex.org/W1974326609","https://openalex.org/W2329922396"],"abstract_inverted_index":{"Turnover":[0],"rates":[1],"of":[2,29,53,84,86,99,108,118,131,141,157,176],"different":[3],"cholesterol":[4,59,80,142,182],"esters":[5,92,113,121,143],"in":[6,89,97,133,144],"rat":[7],"liver":[8,61,79],"and":[9,21,37,57,103,111,122,139],"plasma":[10,22,72,148,166],"were":[11,24,47],"determined":[12],"after":[13],"injecting":[14],"fasting":[15],"rats":[16],"intravenously":[17],"with":[18,44,128,161],"mevalonate-2-C14.":[19],"Liver":[20],"samples":[23,62,149],"collected":[25],"at":[26],"time":[27],"intervals":[28],"21":[30],"min":[31],"to":[32,49,68],"24":[33],"hr.":[34],"Gas\u2013liquid":[35],"chromatography":[36,39],"thin-layer":[38],"on":[40,136],"silica":[41],"gel":[42],"impregnated":[43],"silver":[45],"nitrate":[46],"used":[48],"determine":[50],"specific":[51],"radioactivities":[52],"saturated,":[54],"mono-,":[55],"di-,":[56],"tetra-unsaturated":[58],"esters.The":[60],"showed":[63,73,150],"considerable":[64],"variability":[65],"from":[66],"animal":[67],"animal,":[69],"whereas":[70],"the":[71,82,90,100,104,109,119,129,137,147,158,162,177],"very":[74,178],"little":[75],"individual":[76],"variability.":[77],"In":[78],"esters,":[81,102,183],"rate":[83,107],"appearance":[85],"total":[87],"radioactivity":[88],"monounsaturated":[91],"was":[93,114],"greater":[94,115],"than":[95,116],"that":[96,117],"any":[98],"other":[101,191],"fractional":[105,155],"turnover":[106,156,175],"mono-":[110],"diunsaturated":[112],"saturated":[120],"arachidonate.":[123],"These":[124],"findings":[125,167],"are":[126,193],"consistent":[127],"results":[130],"previous":[132],"vitro":[134],"studies":[135],"hydrolysis":[138],"formation":[140],"liver.":[145],"All":[146],"a":[151,172],"much":[152],"more":[153,173,187],"rapid":[154,174],"monounsaturated,":[159],"compared":[160],"other,":[163],"esters.":[164],"The":[165],"can":[168],"be":[169],"explained":[170],"by":[171],"low":[179],"density":[180],"lipoprotein":[181],"which":[184],"contain":[185],"relatively":[186],"cholesteryl":[188],"oleate,":[189],"although":[190],"explanations":[192],"also":[194],"possible.":[195]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}