{"id":"https://openalex.org/W2395969936","doi":"https://doi.org/10.1385/1-59259-912-5:017","title":"Direct Optical Detection of Protein-Ligand Interactions","display_name":"Direct Optical Detection of Protein-Ligand Interactions","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2395969936","doi":"https://doi.org/10.1385/1-59259-912-5:017","mag":"2395969936","pmid":"https://pubmed.ncbi.nlm.nih.gov/15939992"},"language":"en","primary_location":{"id":"doi:10.1385/1-59259-912-5:017","doi":"https://doi.org/10.1385/1-59259-912-5:017","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-912-5:017","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2478579739","display_name":"Protein-Ligand Interactions"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084149483","display_name":"Frank Gesellchen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106157433","display_name":"University of Kassel","ror":"https://ror.org/04zc7p361","country_code":"DE","type":"education","lineage":["https://openalex.org/I106157433"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Gesellchen","raw_affiliation_strings":["Department of Biochemistry, University of Kassel, Kassel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kassel, Kassel, Germany","institution_ids":["https://openalex.org/I106157433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031745537","display_name":"Bastian Zimmermann","orcid":"https://orcid.org/0000-0001-5475-2054","observed_orcids":["https://orcid.org/0000-0001-5475-2054"]},"institutions":[{"id":"https://openalex.org/I4210115766","display_name":"Biaffin (Germany)","ror":"https://ror.org/02axw6z74","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210115766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bastian Zimmermann","raw_affiliation_strings":["Biaffin GmbH & Co KG, Kassel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biaffin GmbH & Co KG, Kassel, Germany","institution_ids":["https://openalex.org/I4210115766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006568947","display_name":"Friedrich W. Herberg","orcid":"https://orcid.org/0000-0001-7117-7653","observed_orcids":["https://orcid.org/0000-0001-7117-7653"]},"institutions":[{"id":"https://openalex.org/I106157433","display_name":"University of Kassel","ror":"https://ror.org/04zc7p361","country_code":"DE","type":"education","lineage":["https://openalex.org/I106157433"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedrich W. Herberg","raw_affiliation_strings":["Department of Biochemistry, University of Kassel, Kassel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kassel, Kassel, Germany","institution_ids":["https://openalex.org/I106157433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7369,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93098136,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"305","issue":null,"first_page":"17","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10295","display_name":"Plasmonic and Surface Plasmon Research","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-ligand-interactions","display_name":"protein-ligand interactions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/optical-biosensors","display_name":"optical biosensors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"surface plasmon resonance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reflectometric-interference-spectroscopy","display_name":"reflectometric interference spectroscopy","score":0.996999979019165},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/small-molecules","display_name":"small molecules","score":0.8270000219345093},{"id":"https://openalex.org/keywords/serum-proteins","display_name":"serum proteins","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sensor-calibration","display_name":"sensor calibration","score":0.7300000190734863},{"id":"https://openalex.org/keywords/kinetic-analysis","display_name":"kinetic analysis","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.8255473971366882},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.7537795305252075},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5165192484855652},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.4822043180465698},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.4662075936794281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4283590316772461},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4024471640586853},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39640241861343384},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3031649887561798},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12873637676239014},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0919356644153595},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59259-912-5:017","doi":"https://doi.org/10.1385/1-59259-912-5:017","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-912-5:017","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:15939992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15939992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1508623460","https://openalex.org/W1548692828","https://openalex.org/W1558764429","https://openalex.org/W1964731296","https://openalex.org/W1970899943","https://openalex.org/W1976705206","https://openalex.org/W1986113254","https://openalex.org/W1989837159","https://openalex.org/W1991751920","https://openalex.org/W1991764411","https://openalex.org/W1996108041","https://openalex.org/W1998531611","https://openalex.org/W2002195379","https://openalex.org/W2004391976","https://openalex.org/W2010669949","https://openalex.org/W2017306165","https://openalex.org/W2018956074","https://openalex.org/W2019248942","https://openalex.org/W2019414596","https://openalex.org/W2026149471","https://openalex.org/W2028094132","https://openalex.org/W2034098575","https://openalex.org/W2042383380","https://openalex.org/W2043100866","https://openalex.org/W2050494973","https://openalex.org/W2050534908","https://openalex.org/W2051995369","https://openalex.org/W2053166781","https://openalex.org/W2053427272","https://openalex.org/W2053487601","https://openalex.org/W2058609758","https://openalex.org/W2065954013","https://openalex.org/W2069667670","https://openalex.org/W2078302139","https://openalex.org/W2083976465","https://openalex.org/W2084261354","https://openalex.org/W2084954900","https://openalex.org/W2100429345","https://openalex.org/W2123050413","https://openalex.org/W2156294304","https://openalex.org/W2171875719","https://openalex.org/W2314104404"],"related_works":["https://openalex.org/W1515962894","https://openalex.org/W2161960621","https://openalex.org/W6902149974","https://openalex.org/W2970903754","https://openalex.org/W2040554610","https://openalex.org/W2399724811","https://openalex.org/W2546995728","https://openalex.org/W2035903527","https://openalex.org/W2136828798","https://openalex.org/W7165011219"],"abstract_inverted_index":{"Direct":[0],"optical":[1],"detection":[2,40],"provides":[3],"an":[4,98],"excellent":[5],"means":[6],"to":[7,19],"investigate":[8],"interactions":[9],"of":[10,32,41,97,111,128],"molecules":[11],"in":[12,25,116],"biological":[13],"systems.":[14],"The":[15,94],"dynamic":[16],"equilibria":[17],"inherent":[18],"these":[20],"systems":[21],"can":[22],"be":[23],"described":[24,115],"greater":[26],"detail":[27],"by":[28],"recording":[29],"the":[30,45,126],"kinetics":[31],"a":[33,59,119,122,129,140],"biomolecular":[34],"interaction.":[35],"Optical":[36],"biosensors":[37,55],"allow":[38],"direct":[39],"interaction":[42,99,134],"patterns":[43],"without":[44],"need":[46],"for":[47,105,125],"labeling.":[48],"An":[49],"overview":[50],"covering":[51],"several":[52],"commercially":[53],"available":[54],"is":[56,144],"given,":[57],"with":[58,102,135],"focus":[60],"on":[61,64,139],"instruments":[62],"based":[63],"surface":[65],"plasmon":[66],"resonance":[67],"(SPR)":[68],"and":[69,77,82,109],"reflectometric":[70],"interference":[71],"spectroscopy":[72],"(RIFS).":[73],"Potential":[74],"assay":[75],"formats":[76],"experimental":[78],"design,":[79],"appropriate":[80],"controls,":[81],"calibration":[83],"procedures,":[84],"especially":[85],"when":[86],"handling":[87],"low":[88,130],"molecular":[89,131],"weight":[90,132],"substances,":[91],"are":[92,114],"discussed.":[93],"single":[95],"steps":[96],"analysis":[100,127],"combined":[101],"practical":[103,120],"tips":[104],"evaluation,":[106],"data":[107,113],"processing,":[108],"interpretation":[110],"kinetic":[112],"detail.":[117],"In":[118],"example,":[121],"step-by-step":[123],"procedure":[124],"compound":[133],"serum":[136],"protein,":[137],"determined":[138],"commercial":[141],"SPR":[142],"sensor,":[143],"presented.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
