{"id":"https://openalex.org/W2395963407","doi":"https://doi.org/10.14406/acu.2014.006","title":"Inhibitory Effects of Syzygium aromaticum Ethanol Extracts on IgE Mediated RBL-2H3 cell Activation","display_name":"Inhibitory Effects of Syzygium aromaticum Ethanol Extracts on IgE Mediated RBL-2H3 cell Activation","publication_year":2014,"publication_date":"2014-03-27","ids":{"openalex":"https://openalex.org/W2395963407","doi":"https://doi.org/10.14406/acu.2014.006","mag":"2395963407"},"language":"en","primary_location":{"id":"doi:10.14406/acu.2014.006","doi":"https://doi.org/10.14406/acu.2014.006","is_oa":false,"landing_page_url":"https://doi.org/10.14406/acu.2014.006","pdf_url":null,"source":{"id":"https://openalex.org/S4306517621","display_name":"Korean Journal of Acupuncture","issn_l":"2287-3368","issn":["2287-3368","2287-3376"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Acupuncture","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058135488","display_name":"Joon-Hee Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joon-Hee Chung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100616254","display_name":"Yong\u2010Min Kim","orcid":"https://orcid.org/0000-0002-3064-9412","observed_orcids":["https://orcid.org/0000-0002-3064-9412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Min Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075178914","display_name":"Jong-Phil Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong-Phil Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629609","display_name":"Tae\u2010Yeon Kim","orcid":"https://orcid.org/0000-0003-4743-6023","observed_orcids":["https://orcid.org/0000-0003-4743-6023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae-Yeon Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020573367","display_name":"Ee\u2010Hwa Kim","orcid":"https://orcid.org/0000-0003-0400-9056","observed_orcids":["https://orcid.org/0000-0003-0400-9056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ee-Hwa Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"1","first_page":"14","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syzygium-aromaticum","display_name":"Syzygium aromaticum","score":1.0},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.968999981880188},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ige-mediated-activation","display_name":"IgE-mediated activation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antiallergic-activity","display_name":"anti-allergic activity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.8130000233650208},{"id":"https://openalex.org/keywords/beta-hexosaminidase-release","display_name":"beta-hexosaminidase release","score":0.8799999952316284},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.906000018119812},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/allergic-reactions","display_name":"allergic reactions","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8446232676506042},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.8067965507507324},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7420367002487183},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5553805828094482},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5425028204917908},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5347033739089966},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5063821077346802},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5024354457855225},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4950065016746521},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4653303027153015},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4481047987937927},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.42776575684547424},{"id":"https://openalex.org/C2776953665","wikidata":"https://www.wikidata.org/wiki/Q4732121","display_name":"Allergic response","level":4,"score":0.4169895350933075},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.37981700897216797},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3445158004760742},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3099094033241272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30948716402053833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2854684591293335},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24324706196784973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1916603446006775},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15109285712242126},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.050190091133117676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14406/acu.2014.006","doi":"https://doi.org/10.14406/acu.2014.006","is_oa":false,"landing_page_url":"https://doi.org/10.14406/acu.2014.006","pdf_url":null,"source":{"id":"https://openalex.org/S4306517621","display_name":"Korean Journal of Acupuncture","issn_l":"2287-3368","issn":["2287-3368","2287-3376"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Acupuncture","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1526116399","https://openalex.org/W1564011208","https://openalex.org/W1587892340","https://openalex.org/W1750204594","https://openalex.org/W1983399406","https://openalex.org/W1984582122","https://openalex.org/W1990746160","https://openalex.org/W2018939007","https://openalex.org/W2020877804","https://openalex.org/W2026687368","https://openalex.org/W2038175841","https://openalex.org/W2048345403","https://openalex.org/W2050066579","https://openalex.org/W2082379544","https://openalex.org/W2093216993","https://openalex.org/W2140152586","https://openalex.org/W2158921004","https://openalex.org/W2397705603","https://openalex.org/W4313317760","https://openalex.org/W6712559572"],"related_works":["https://openalex.org/W2073133444","https://openalex.org/W2980084464","https://openalex.org/W2102239399","https://openalex.org/W2400983259","https://openalex.org/W2604214581","https://openalex.org/W2491312303","https://openalex.org/W1982912970","https://openalex.org/W2039685238","https://openalex.org/W2339076098","https://openalex.org/W2018877931"],"abstract_inverted_index":{"Objectives":[0],":":[1,32,94,125],"In":[2],"this":[3],"report,":[4],"we":[5,76],"investigated":[6],"the":[7,19,64,71,78,83,117,144],"effect":[8,67,79],"of":[9,12,29,44,66,68,73,80,85,146],"ethanol":[10,133],"extract":[11,134],"Syzygium":[13,131],"aromaticum(L.)":[14],"Merr.":[15],"&":[16],"Perry.(SAE)":[17],"on":[18,34,70,82,99],"RBL-2H3":[20,35,108],"cell-mediated":[21],"allergic":[22,139],"response":[23],"and":[24,50,55,111,141],"studied":[25],"its":[26],"possible":[27],"mechanisms":[28,65],"action.":[30],"Methods":[31],"Cytotoxicity":[33],"cell":[36,109,137],"was":[37,46],"evaluated":[38],"by":[39,48,60],"MTT":[40],"assay.":[41,62],"Anti-allergic":[42],"activity":[43],"SAE":[45,69,81,95,105,114],"assessed":[47],"-Hexosaminidase":[49],"Histamine":[51,56],"secretion,":[52],"-":[53],"Hexosaminidase":[54],"secretion":[57,72],"were":[58],"measured":[59],"ELISA":[61],"Evaluate":[63],"degranulate":[74],"mediators,":[75],"examined":[77],"activation":[84],"mitogen-activated":[86,120],"protein":[87,121],"kinases":[88],"using":[89],"western":[90],"blot":[91],"analysis.":[92],"Results":[93],"had":[96],"no":[97],"cytotoxicity":[98],"rat":[100],"basophilic":[101],"leukemia":[102],"cell(RBL-2H3).":[103],"Moreover":[104],"dose-dependently":[106],"inhibited":[107],"degranulation":[110],"histamine":[112],"release.":[113],"specifically":[115],"blocked":[116],"IgE-induced":[118],"p38":[119,147],"kinase":[122],"activation.":[123],"Conclusions":[124],"Our":[126],"findings":[127],"provide":[128],"evidence":[129],"that":[130],"aromaticum":[132],"inhibits":[135],"mast":[136],"derived":[138],"reaction,":[140],"also":[142],"demonstrate":[143],"involvement":[145],"MAPK":[148],"phosphorylation.":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
