{"id":"https://openalex.org/W2395950097","doi":"https://doi.org/10.14374/hfs.2015.23.1.111","title":"Antioxidant effect of Woogyuyeum against hydrogen peroxide-induced oxidative stress in Leydig cells","display_name":"Antioxidant effect of Woogyuyeum against hydrogen peroxide-induced oxidative stress in Leydig cells","publication_year":2015,"publication_date":"2015-06-30","ids":{"openalex":"https://openalex.org/W2395950097","doi":"https://doi.org/10.14374/hfs.2015.23.1.111","mag":"2395950097"},"language":"en","primary_location":{"id":"doi:10.14374/hfs.2015.23.1.111","doi":"https://doi.org/10.14374/hfs.2015.23.1.111","is_oa":true,"landing_page_url":"https://doi.org/10.14374/hfs.2015.23.1.111","pdf_url":"http://koreascience.or.kr:80/article/JAKO201525850280522.pdf","source":{"id":"https://openalex.org/S4306512052","display_name":"Herbal Formula Science","issn_l":"1229-1218","issn":["1229-1218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Herbal Formula Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO201525850280522.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100430994","display_name":"Soo Hyun Kim","orcid":"https://orcid.org/0000-0002-1293-1377","observed_orcids":["https://orcid.org/0000-0002-1293-1377"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo Hyun Kim","raw_affiliation_strings":["Department of Prescriptionology , College of Korean Medicine , Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prescriptionology , College of Korean Medicine , Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072270016","display_name":"Do Rim Kim","orcid":"https://orcid.org/0000-0002-8131-3409","observed_orcids":["https://orcid.org/0000-0002-8131-3409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Do Rim Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102179124","display_name":"Mun Seog Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mun Seog Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102968663","display_name":"Seong Kyu Park","orcid":"https://orcid.org/0000-0002-3589-6180","observed_orcids":["https://orcid.org/0000-0002-3589-6180"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Kyu Park","raw_affiliation_strings":["Department of Prescriptionology , College of Korean Medicine , Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prescriptionology , College of Korean Medicine , Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2676,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61247067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"1","first_page":"111","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.3206000030040741,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.3206000030040741,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.75},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.625},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.9034798741340637},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.8811243176460266},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8490796685218811},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.8267471790313721},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7492684125900269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6685981750488281},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.6213405728340149},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.620387613773346},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5127595067024231},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.43774253129959106},{"id":"https://openalex.org/C2993790521","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxide","level":4,"score":0.43538594245910645},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.41971904039382935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4155372679233551},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3781558573246002},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2978738844394684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15586432814598083},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14506366848945618},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14374/hfs.2015.23.1.111","doi":"https://doi.org/10.14374/hfs.2015.23.1.111","is_oa":true,"landing_page_url":"https://doi.org/10.14374/hfs.2015.23.1.111","pdf_url":"http://koreascience.or.kr:80/article/JAKO201525850280522.pdf","source":{"id":"https://openalex.org/S4306512052","display_name":"Herbal Formula Science","issn_l":"1229-1218","issn":["1229-1218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Herbal Formula Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14374/hfs.2015.23.1.111","doi":"https://doi.org/10.14374/hfs.2015.23.1.111","is_oa":true,"landing_page_url":"https://doi.org/10.14374/hfs.2015.23.1.111","pdf_url":"http://koreascience.or.kr:80/article/JAKO201525850280522.pdf","source":{"id":"https://openalex.org/S4306512052","display_name":"Herbal Formula Science","issn_l":"1229-1218","issn":["1229-1218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Herbal Formula Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2395950097.pdf","grobid_xml":"https://content.openalex.org/works/W2395950097.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W121710899","https://openalex.org/W191793640","https://openalex.org/W202514019","https://openalex.org/W1030653330","https://openalex.org/W2114918609","https://openalex.org/W2272838734","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2007842448","https://openalex.org/W2131515392","https://openalex.org/W7164879194","https://openalex.org/W922367674","https://openalex.org/W2370217675","https://openalex.org/W3010722538","https://openalex.org/W2093214328","https://openalex.org/W1897168898","https://openalex.org/W2260473939","https://openalex.org/W2038092773"],"abstract_inverted_index":{"Objectives":[0],":":[1,23,87,183],"The":[2,61,109],"purpose":[3],"of":[4,13,16,29,51,64,121,135,142,166,179],"this":[5],"study":[6],"was":[7,123,159,171],"to":[8,153],"investigate":[9],"the":[10,26,47,118,150],"antioxidant":[11,119,139,188],"activity":[12,79,158,170],"water":[14],"extract":[15],"Woogyuyeum":[17],"(WGY)":[18],"in":[19,31,46,83,96,105,115,125,195],"Leydig":[20,34,39,84,196],"cells.":[21,85,98,197],"Methods":[22],"We":[24],"investigated":[25],"cytoprotective":[27],"effect":[28],"WGY":[30,43,65,91,99,122,136,147,167,186],"cultured":[32],"mouse":[33],"cells":[35,40,143],"by":[36,112],"MTT":[37],"assay.":[38],"treated":[41],"with":[42,144],"were":[44,81],"incubated":[45],"presence":[48],"or":[49],"absence":[50],"50":[52],"\u03bcM":[53],"hydrogen":[54,67,113,191],"peroxide":[55,72,114],"at":[56,161,174],"37\u2103":[57],"for":[58],"24":[59],"h.":[60],"protective":[62],"effects":[63,120],"against":[66,190],"peroxide-induced":[68,192],"oxidative":[69,193],"stress,":[70],"lipid":[71],"(LPO),":[73],"superoxide":[74],"dismutase":[75],"(SOD),":[76],"and":[77,168],"catalase":[78,169],"assays":[80],"performed":[82],"Results":[86],"As":[88],"a":[89],"result,":[90],"showed":[92,100,137],"no":[93],"significant":[94],"cytotoxicity":[95,110],"Leygdig":[97,116],"cell":[101],"viability":[102],"as":[103],"103.65%":[104],"5":[106],"\u03bcg/ml":[107,133,146,164,177],"concentrations.":[108],"induced":[111],"cells,":[117],"increased":[124,160,173],"1,":[126,162],"5,":[127],"50,":[128,175],"100":[129,132,145,163,176],"ug/ml":[130],"concentraions.":[131],"concentration":[134,152,165],"maximum":[138],"effects.":[140],"Treatment":[141],"significantly":[148,172],"reduced":[149],"MDA":[151],"0.23":[154],"nmoles/mg":[155],"protein.":[156],"SOD":[157],"concentrations":[178],"WGY,":[180],"respectively.":[181],"Conclusions":[182],"In":[184],"conclusion,":[185],"has":[187],"activities":[189],"stress":[194]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}