{"id":"https://openalex.org/W2395941336","doi":null,"title":"The serum osteocalcin levels in adult and aged hypothyroid patients.","display_name":"The serum osteocalcin levels in adult and aged hypothyroid patients.","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W2395941336","mag":"2395941336","pmid":"https://pubmed.ncbi.nlm.nih.gov/3264931"},"language":"en","primary_location":{"id":"pmid:3264931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3264931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologie","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041052589","display_name":"Ligia Simionescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116739","display_name":"Institutul Na\u021bional de Endocrinologie C.I. Parhon","ror":"https://ror.org/02b4rb907","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210116739"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"L Simionescu","raw_affiliation_strings":["C. I. Parhon Institute of Endocrinology, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. I. Parhon Institute of Endocrinology, Bucharest, Romania","institution_ids":["https://openalex.org/I4210116739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075616412","display_name":"Leonard Dumitriu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Dumitriu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030832725","display_name":"V Dimitriu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Dimitriu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010689448","display_name":"D Zamfir-Grigorescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Zamfir-Grigorescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020347258","display_name":"E Dumitriu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Dumitriu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069503178","display_name":"G C\u00e2mpean","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G C\u00e2mpean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Ionescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ionescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032030641","display_name":"Mariana Purice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Purice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3111,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63637402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"4","first_page":"255","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.26420000195503235,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.968999981880188},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6399999856948853},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.5490000247955322},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.9090241193771362},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.8554767370223999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8402314186096191},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.824619472026825},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.710470974445343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6955075263977051},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.43269792199134827},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20635375380516052},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.123740553855896},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.11013805866241455},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06610068678855896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015055","descriptor_name":"1-Carboxyglutamic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3264931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3264931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinologie","raw_type":"Comparative Study"},{"id":"mag:2395941336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3264931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2392493965","https://openalex.org/W2357787494","https://openalex.org/W2106720703","https://openalex.org/W2996593171","https://openalex.org/W2073693274","https://openalex.org/W2218475635","https://openalex.org/W7125140504","https://openalex.org/W2038198036","https://openalex.org/W2261093661","https://openalex.org/W2610505965"],"abstract_inverted_index":{"Osteocalcin":[0],"(OC)":[1],"or":[2,10,145],"the":[3,31,69,103,115,131,138,152,175],"bone":[4,19],"protein":[5],"containing":[6],"gamma-carboxyglutamic":[7],"acid":[8],"(BGP":[9],"Gla-P),":[11],"is":[12],"a":[13],"specific":[14],"and":[15,51,80,156,181],"sensitive":[16],"marker":[17],"of":[18,33,130,174],"turnover.":[20],"A":[21],"radioimmunoassay":[22],"(RIA)":[23],"system":[24],"for":[25],"human":[26],"osteocalcin":[27,37],"was":[28,38,135],"developed":[29],"with":[30],"sensitivity":[32],"0.5":[34],"ng/ml.":[35,95,171],"The":[36,172],"measured":[39],"in":[40,67,102,137,151,178],"sera":[41],"from":[42,61,81],"33":[43],"hormonally":[44,63,82,143,161],"and/or":[45],"clinically":[46,164],"hypothyroid":[47,104,116,146,165,179],"patients:":[48],"12":[49],"adult":[50,65,84,105,180],"21":[52],"aged":[53,117,139,182],"patients.":[54],"For":[55],"comparison,":[56],"blood":[57],"samples":[58],"were":[59,72,100],"collected":[60],"14":[62],"hyperthyroid":[64,88],"patients":[66,85,106,118,142,159,183],"whom":[68],"OC":[70,91,98,132,149,168,176],"levels":[71,99,134,150,169,177],"16.23":[73],"+/-":[74,78,93,109,120],"7.57":[75],"ng/ml":[76,111,122,155],"(mean":[77],"SD)":[79],"euthyroid":[83,162],"(previously":[86],"treated":[87],"patients)":[89],"having":[90,147],"9.76":[92],"5.32":[94],"Abnormal":[96],"low":[97,167],"noted":[101],"group:":[107],"1.04":[108],"0.23":[110],"by":[112],"comparison":[113],"to":[114],"3.76":[119],"2.38":[121],"(p":[123],"less":[124],"than":[125],"0.001).":[126],"Moreover,":[127],"great":[128],"variability":[129],"serum":[133],"observed":[136],"group,":[140],"four":[141],"eu-":[144],"high":[148],"range:":[153],"13.29-55.45":[154],"other":[157],"three":[158],"although":[160],"but":[163],"had":[166],"0.88-2.27":[170],"abnormalities":[173],"are":[184],"discussed.":[185]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}