{"id":"https://openalex.org/W2395919741","doi":"https://doi.org/10.1007/s12199-016-0540-4","title":"Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression","display_name":"Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression","publication_year":2016,"publication_date":"2016-05-25","ids":{"openalex":"https://openalex.org/W2395919741","doi":"https://doi.org/10.1007/s12199-016-0540-4","mag":"2395919741","pmid":"https://pubmed.ncbi.nlm.nih.gov/27225276","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5305992"},"language":"en","primary_location":{"id":"doi:10.1007/s12199-016-0540-4","doi":"https://doi.org/10.1007/s12199-016-0540-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12199-016-0540-4","pdf_url":"https://environhealthprevmed.biomedcentral.com/track/pdf/10.1007/s12199-016-0540-4","source":{"id":"https://openalex.org/S110451752","display_name":"Environmental Health and Preventive Medicine","issn_l":"1342-078X","issn":["1342-078X","1347-4715"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health and Preventive Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://environhealthprevmed.biomedcentral.com/track/pdf/10.1007/s12199-016-0540-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075711941","display_name":"Khyber Saify","orcid":"https://orcid.org/0000-0003-1461-3943","observed_orcids":["https://orcid.org/0000-0003-1461-3943"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Khyber Saify","raw_affiliation_strings":["Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041290970","display_name":"Iraj Saadat","orcid":"https://orcid.org/0000-0002-8169-4707","observed_orcids":["https://orcid.org/0000-0002-8169-4707"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Iraj Saadat","raw_affiliation_strings":["Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021993256","display_name":"Mostafa Saadat","orcid":"https://orcid.org/0000-0002-0021-4055","observed_orcids":["https://orcid.org/0000-0002-0021-4055"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mostafa Saadat","raw_affiliation_strings":["Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran. saadat@shirazu.ac.ir","Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran. saadat@shirazu.ac.ir","institution_ids":["https://openalex.org/I166459259"]},{"raw_affiliation_string":"Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran","institution_ids":["https://openalex.org/I166459259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021993256"],"corresponding_institution_ids":["https://openalex.org/I166459259"],"apc_list":{"value":2145,"currency":"USD","value_usd":2145},"apc_paid":{"value":2145,"currency":"USD","value_usd":2145},"fwci":1.5718,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.8200149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"5","first_page":"382","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cat-gene","display_name":"cat gene","score":0.7730000019073486},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.7459999918937683},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.609000027179718},{"id":"https://openalex.org/keywords/peripheral-blood-cells","display_name":"peripheral blood cells","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6827542781829834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6352734565734863},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6021762490272522},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5744553804397583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5717047452926636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5324118137359619},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5144317746162415},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4437108337879181},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43816059827804565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4175504744052887},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4106740951538086},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35875338315963745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20015448331832886},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.127976655960083}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013334","descriptor_name":"Students","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014495","descriptor_name":"Universities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12199-016-0540-4","doi":"https://doi.org/10.1007/s12199-016-0540-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12199-016-0540-4","pdf_url":"https://environhealthprevmed.biomedcentral.com/track/pdf/10.1007/s12199-016-0540-4","source":{"id":"https://openalex.org/S110451752","display_name":"Environmental Health and Preventive Medicine","issn_l":"1342-078X","issn":["1342-078X","1347-4715"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health and Preventive Medicine","raw_type":"journal-article"},{"id":"pmid:27225276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27225276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health and preventive medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5305992","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5305992/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Health Prev Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12199-016-0540-4","doi":"https://doi.org/10.1007/s12199-016-0540-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12199-016-0540-4","pdf_url":"https://environhealthprevmed.biomedcentral.com/track/pdf/10.1007/s12199-016-0540-4","source":{"id":"https://openalex.org/S110451752","display_name":"Environmental Health and Preventive Medicine","issn_l":"1342-078X","issn":["1342-078X","1347-4715"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health and Preventive Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1982329176","display_name":null,"funder_award_id":"93GRD3M1741","funder_id":"https://openalex.org/F4320323101","funder_display_name":"Shiraz University"}],"funders":[{"id":"https://openalex.org/F4320323101","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2395919741.pdf","grobid_xml":"https://content.openalex.org/works/W2395919741.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1583052686","https://openalex.org/W1803016753","https://openalex.org/W1854800765","https://openalex.org/W1946623753","https://openalex.org/W1969077764","https://openalex.org/W1974874761","https://openalex.org/W1975773180","https://openalex.org/W1982097792","https://openalex.org/W1995754811","https://openalex.org/W2037908463","https://openalex.org/W2054727077","https://openalex.org/W2067825692","https://openalex.org/W2071679440","https://openalex.org/W2072157296","https://openalex.org/W2074289572","https://openalex.org/W2085437672","https://openalex.org/W2111816936","https://openalex.org/W2114570899","https://openalex.org/W2126783526","https://openalex.org/W2128794003","https://openalex.org/W2146109030","https://openalex.org/W2161555740","https://openalex.org/W2171805636","https://openalex.org/W2173709855","https://openalex.org/W2180590706","https://openalex.org/W2204835925","https://openalex.org/W2287611719","https://openalex.org/W2320949851","https://openalex.org/W2396258599","https://openalex.org/W2407406014","https://openalex.org/W2412608625","https://openalex.org/W2412731695","https://openalex.org/W2413024693","https://openalex.org/W2519663982","https://openalex.org/W4242270522"],"related_works":["https://openalex.org/W2072157296","https://openalex.org/W2407406014","https://openalex.org/W4254596902","https://openalex.org/W2374223237","https://openalex.org/W2106667781","https://openalex.org/W827015488","https://openalex.org/W2128794003","https://openalex.org/W2774917268","https://openalex.org/W3032472607","https://openalex.org/W2085437672"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Catalase":[1],"(CAT,":[2],"OMIM:":[3],"115500)":[4],"is":[5,82],"one":[6],"of":[7,20,27,39,57,73,78,106,110,116,147],"the":[8,18,36,40,54,70,74,79,85,92,117,150,161,173,202,217],"major":[9],"antioxidant":[10],"enzymes,":[11],"which":[12],"plays":[13],"an":[14],"important":[15],"role":[16],"in":[17,35,96,149,164],"clearance":[19],"reactive":[21],"oxygen":[22],"species.":[23],"Three":[24],"genetic":[25,89],"polymorphisms":[26,51,67,119,212],"A-21T":[28],"(rs7943316),":[29],"C-262T":[30],"(rs1001179),":[31],"and":[32,91,154,188,194],"C-844T":[33],"(rs769214)":[34],"promoter":[37],"region":[38],"CAT":[41,93,118,128,148,197],"have":[42],"been":[43,47],"reported.":[44],"It":[45],"has":[46],"suggested":[48],"that":[49,65,210],"these":[50,66,88,211],"may":[52,68],"alter":[53,69],"recognition":[55],"sites":[56],"transcriptional":[58],"factors,":[59],"therefore":[60],"it":[61],"might":[62],"be":[63],"concluded":[64],"expression":[71,130],"levels":[72,95,131,146,163,199],"gene.":[75],"The":[76,102,126,144,186,206],"aim":[77],"present":[80,103,207],"study":[81,104,174],"to":[83],"evaluate":[84],"associations":[86],"between":[87,172],"variations":[90],"mRNA":[94,129,145,162,198],"human":[97],"peripheral":[98],"blood":[99],"cells.":[100],"METHODS:":[101],"consisted":[105],"47":[107],"healthy":[108],"students":[109],"Shiraz":[111],"University":[112],"(south-west":[113],"Iran).":[114],"Genotypes":[115],"were":[120,132,158,213],"determined":[121],"by":[122],"PCR":[123],"based":[124],"method.":[125],"quantitative":[127,135],"investigated":[133],"using":[134],"real-time":[136],"PCR.":[137],"RESULTS:":[138],"=":[139,177,180],"17.03,":[140],"P":[141,183],"<":[142,184],"0.0001).":[143],"AC/TT,":[151],"TC/TC,":[152],"TC/TT,":[153],"TC/TC":[155,187],"diplotypes":[156,190],"significantly":[157,214],"higher":[159],"than":[160],"AC/AC":[165,203],"diplotype.":[166,204],"There":[167],"was":[168],"a":[169],"significant":[170],"difference":[171],"genotypes":[175],"(F":[176],"9.24;":[178],"df":[179],"5,":[181],"41;":[182],"0.001).":[185],"TT/TT":[189],"showed":[191],"about":[192],"2":[193],"4":[195],"folds":[196],"compared":[200],"with":[201,216],"CONCLUSIONS:":[205],"findings":[208],"indicated":[209],"associated":[215],"gene":[218],"expression.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}