{"id":"https://openalex.org/W2395919070","doi":null,"title":"A high frequency of N-RAS oncogene mutations in multiple myeloma.","display_name":"A high frequency of N-RAS oncogene mutations in multiple myeloma.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2395919070","mag":"2395919070","pmid":"https://pubmed.ncbi.nlm.nih.gov/1421173"},"language":"en","primary_location":{"id":"pmid:1421173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1421173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of hematology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052483359","display_name":"Kazuaki Tanaka","orcid":"https://orcid.org/0000-0002-6763-7773","observed_orcids":["https://orcid.org/0000-0002-6763-7773"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Tanaka","raw_affiliation_strings":["Department of Hematology, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083729467","display_name":"Miho Takechi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takechi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034298297","display_name":"Hideki Asaoku","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Asaoku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021775720","display_name":"Hiroo Dohy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Dohy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113571315","display_name":"N Kamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Kamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3036,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77276704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"56","issue":"2","first_page":"119","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/n-ras-oncogene","display_name":"N-ras oncogene","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.8730000257492065},{"id":"https://openalex.org/keywords/kras-oncogene","display_name":"K-ras oncogene","score":0.781000018119812},{"id":"https://openalex.org/keywords/codon-61-mutation","display_name":"codon 61 mutation","score":0.843999981880188},{"id":"https://openalex.org/keywords/codon-12-mutation","display_name":"codon 12 mutation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/codon-13-mutation","display_name":"codon 13 mutation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.8148180246353149},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6711708903312683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5500999689102173},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.48948514461517334},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.48603659868240356},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.46824324131011963},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4542953073978424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43859827518463135},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4208020567893982},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35717877745628357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3245934545993805},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3109475076198578},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3076018989086151},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2650378942489624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21123751997947693},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.10091900825500488}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1421173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1421173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of hematology","raw_type":"Journal Article"},{"id":"mag:2395919070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1421173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217215059","https://openalex.org/W2402284595","https://openalex.org/W1985196751","https://openalex.org/W115820681","https://openalex.org/W1968111572","https://openalex.org/W66769261","https://openalex.org/W2356217487","https://openalex.org/W2003442933","https://openalex.org/W178019285","https://openalex.org/W2080164596"],"abstract_inverted_index":{"Mutation":[0],"of":[1,42,50,62,69,80,122,127,137,188],"the":[2,14,43,75,81,87,91,98,123,128,135,163,169,186],"RAS":[3,138],"oncogene":[4,45,83,171,178],"was":[5,34,84,165],"studied":[6],"in":[7,31,48,55,60,141,147,185],"ten":[8,63],"patients":[9,33,52,64,95,124],"with":[10],"multiple":[11,142,189],"myeloma,":[12],"and":[13,38,59,114,159],"DNA":[15,70],"from":[16,24,71],"nude":[17],"mouse":[18],"tumors":[19],"formed":[20],"by":[21,36,54,66,97],"cells":[22],"obtained":[23],"tumorigenecity":[25],"assays":[26],"(in":[27],"vivo":[28,56],"selection":[29,57],"assays)":[30],"these":[32],"analyzed":[35],"PCR":[37,67,99],"oligonucleotide":[39],"hybridization.":[40],"Mutations":[41],"N-RAS":[44,82,93,170,177],"were":[46],"identified":[47],"two":[49,76,108,115],"three":[51],"investigated":[53,65,96],"assay":[58],"five":[61,92],"analysis":[68],"myeloma":[72,143],"cells.":[73],"In":[74],"former":[77],"patients,":[78],"mutation":[79,104,140,164],"observed":[85,166],"at":[86,105,111,118,168],"61st":[88],"codon.":[89],"Of":[90],"mutant-positive":[94],"analysis,":[100],"one":[101],"had":[102,109,116,125],"a":[103],"codon":[106,112,119],"12,":[107],"mutations":[110,117,126],"13,":[113],"61.":[120],"None":[121],"K-RAS":[129],"oncogene.":[130],"These":[131],"results":[132],"suggest":[133],"that":[134,176],"frequency":[136],"gene":[139],"is":[144,174],"higher":[145],"than":[146],"other":[148],"lymphoid":[149],"malignancies":[150],"such":[151],"as":[152],"acute":[153],"lymphocytic":[154,157],"leukemia,":[155,158],"chronic":[156],"malignant":[160],"lymphoma.":[161],"As":[162],"only":[167],"level,":[172],"it":[173],"speculated":[175],"activation":[179],"might":[180],"play":[181],"an":[182],"important":[183],"role":[184],"progression":[187],"myeloma.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
