{"id":"https://openalex.org/W2395865447","doi":"https://doi.org/10.1142/s0192415x16500476","title":"Effects ofPanax notoginsengon the Metastasis of Human Colorectal Cancer Cells","display_name":"Effects ofPanax notoginsengon the Metastasis of Human Colorectal Cancer Cells","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2395865447","doi":"https://doi.org/10.1142/s0192415x16500476","mag":"2395865447","pmid":"https://pubmed.ncbi.nlm.nih.gov/27222068"},"language":"en","primary_location":{"id":"doi:10.1142/s0192415x16500476","doi":"https://doi.org/10.1142/s0192415x16500476","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0192415x16500476","pdf_url":null,"source":{"id":"https://openalex.org/S118315377","display_name":"The American Journal of Chinese Medicine","issn_l":"0090-2942","issn":["0090-2942","0192-415X","1793-6853"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043554321","display_name":"Shu\u2010Ling Hsieh","orcid":"https://orcid.org/0000-0002-5972-0112","observed_orcids":["https://orcid.org/0000-0002-5972-0112"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I43518871","display_name":"National Kaohsiung Marine University","ror":"https://ror.org/00ca6fy54","country_code":"TW","type":"education","lineage":["https://openalex.org/I43518871","https://openalex.org/I4387154394"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Ling Hsieh","raw_affiliation_strings":["Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan","institution_ids":["https://openalex.org/I43518871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010247574","display_name":"Shuchen Hsieh","orcid":"https://orcid.org/0000-0001-5358-0836","observed_orcids":["https://orcid.org/0000-0001-5358-0836"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I43518871","display_name":"National Kaohsiung Marine University","ror":"https://ror.org/00ca6fy54","country_code":"TW","type":"education","lineage":["https://openalex.org/I43518871","https://openalex.org/I4387154394"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shuchen Hsieh","raw_affiliation_strings":["Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan","institution_ids":["https://openalex.org/I43518871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085580716","display_name":"Yu-Hao Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43518871","display_name":"National Kaohsiung Marine University","ror":"https://ror.org/00ca6fy54","country_code":"TW","type":"education","lineage":["https://openalex.org/I43518871","https://openalex.org/I4387154394"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Hao Kuo","raw_affiliation_strings":["Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan","institution_ids":["https://openalex.org/I43518871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083651965","display_name":"Jyh\u2010Jye Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32303042","display_name":"Tajen University","ror":"https://ror.org/01fvf0d84","country_code":"TW","type":"education","lineage":["https://openalex.org/I32303042"]},{"id":"https://openalex.org/I64045040","display_name":"Fooyin University","ror":"https://ror.org/03pfmgq50","country_code":"TW","type":"education","lineage":["https://openalex.org/I64045040"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jyh-Jye Wang","raw_affiliation_strings":["Department of Food Science and Technology, Tajen University, Pingtung 90741, Taiwan","Department of Nutrition and Health Science, Fooyin University, Kaohsiung 83102, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Tajen University, Pingtung 90741, Taiwan","institution_ids":["https://openalex.org/I32303042"]},{"raw_affiliation_string":"Department of Nutrition and Health Science, Fooyin University, Kaohsiung 83102, Taiwan","institution_ids":["https://openalex.org/I64045040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088833963","display_name":"Jinn\u2010Chyi Wang","orcid":"https://orcid.org/0000-0002-4964-9965","observed_orcids":["https://orcid.org/0000-0002-4964-9965"]},"institutions":[{"id":"https://openalex.org/I32303042","display_name":"Tajen University","ror":"https://ror.org/01fvf0d84","country_code":"TW","type":"education","lineage":["https://openalex.org/I32303042"]},{"id":"https://openalex.org/I64045040","display_name":"Fooyin University","ror":"https://ror.org/03pfmgq50","country_code":"TW","type":"education","lineage":["https://openalex.org/I64045040"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jinn-Chyi Wang","raw_affiliation_strings":["Department of Food Science and Technology, Tajen University, Pingtung 90741, Taiwan","Department of Nutrition and Health Science, Fooyin University, Kaohsiung 83102, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Tajen University, Pingtung 90741, Taiwan","institution_ids":["https://openalex.org/I32303042"]},{"raw_affiliation_string":"Department of Nutrition and Health Science, Fooyin University, Kaohsiung 83102, Taiwan","institution_ids":["https://openalex.org/I64045040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066651956","display_name":"Chih\u2010Chung Wu","orcid":"https://orcid.org/0000-0002-6518-5312","observed_orcids":["https://orcid.org/0000-0002-6518-5312"]},"institutions":[{"id":"https://openalex.org/I80327900","display_name":"Chang Jung Christian University","ror":"https://ror.org/02s3d7j94","country_code":"TW","type":"education","lineage":["https://openalex.org/I80327900"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Chung Wu","raw_affiliation_strings":["Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan","institution_ids":["https://openalex.org/I80327900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4309,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86716742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"04","first_page":"851","last_page":"870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panax-notoginseng","display_name":"Panax notoginseng","score":0.996999979019165},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.9089999794960022},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.875},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.746999979019165},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8510000109672546},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antimetastatic-effect","display_name":"antimetastatic effect","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.6572169065475464},{"id":"https://openalex.org/C2781212864","wikidata":"https://www.wikidata.org/wiki/Q15551438","display_name":"Panax notoginseng","level":3,"score":0.6389334201812744},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6092145442962646},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5156513452529907},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48457610607147217},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4777223765850067},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4644142985343933},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4471556842327118},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4319222867488861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4214288294315338},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.4199945330619812},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3760906159877777},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3586421608924866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3459985852241516},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3247469663619995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3143226206302643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29157328605651855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23155805468559265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21411362290382385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1091010570526123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053723","descriptor_name":"Panax notoginseng","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0192415x16500476","doi":"https://doi.org/10.1142/s0192415x16500476","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0192415x16500476","pdf_url":null,"source":{"id":"https://openalex.org/S118315377","display_name":"The American Journal of Chinese Medicine","issn_l":"0090-2942","issn":["0090-2942","0192-415X","1793-6853"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Chinese Medicine","raw_type":"journal-article"},{"id":"pmid:27222068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27222068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of Chinese medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W163232160","https://openalex.org/W1552616562","https://openalex.org/W1560758904","https://openalex.org/W1629179716","https://openalex.org/W1775749144","https://openalex.org/W1967453876","https://openalex.org/W1970780458","https://openalex.org/W1971663228","https://openalex.org/W1972974383","https://openalex.org/W1981989535","https://openalex.org/W1985650202","https://openalex.org/W1988150665","https://openalex.org/W1989771147","https://openalex.org/W1992588954","https://openalex.org/W1994490125","https://openalex.org/W2000740254","https://openalex.org/W2001913172","https://openalex.org/W2002603913","https://openalex.org/W2003292748","https://openalex.org/W2010045296","https://openalex.org/W2010308216","https://openalex.org/W2010414816","https://openalex.org/W2013614177","https://openalex.org/W2018795692","https://openalex.org/W2019683307","https://openalex.org/W2020830322","https://openalex.org/W2023247554","https://openalex.org/W2025077054","https://openalex.org/W2026477506","https://openalex.org/W2035068715","https://openalex.org/W2050726791","https://openalex.org/W2052561474","https://openalex.org/W2064949856","https://openalex.org/W2076312465","https://openalex.org/W2076435848","https://openalex.org/W2080953466","https://openalex.org/W2082013762","https://openalex.org/W2083531592","https://openalex.org/W2086857519","https://openalex.org/W2088356990","https://openalex.org/W2091720415","https://openalex.org/W2096444752","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2109658199","https://openalex.org/W2118288659","https://openalex.org/W2126516854","https://openalex.org/W2136993284","https://openalex.org/W2140551998","https://openalex.org/W2144638161","https://openalex.org/W2149504763","https://openalex.org/W2151483995","https://openalex.org/W2154771779","https://openalex.org/W2157941198","https://openalex.org/W2158862003","https://openalex.org/W2161625612","https://openalex.org/W2165200432","https://openalex.org/W2166153671","https://openalex.org/W2168110794","https://openalex.org/W2168197406","https://openalex.org/W2396423701","https://openalex.org/W2415469895","https://openalex.org/W4245635197","https://openalex.org/W4366067477"],"related_works":["https://openalex.org/W2550971471","https://openalex.org/W1993695022","https://openalex.org/W1967453876","https://openalex.org/W7132822485","https://openalex.org/W4366067477","https://openalex.org/W2062936488","https://openalex.org/W7100276303","https://openalex.org/W2052561474","https://openalex.org/W2470105075","https://openalex.org/W2085707480"],"abstract_inverted_index":{"The":[0,26,54,67,90,111,191],"goal":[1],"of":[2,10,20,35,59,69,130,142,188,196,227,237,258],"this":[3,52,178],"study":[4],"was":[5,182],"to":[6,101,106,184],"investigate":[7],"the":[8,11,18,33,47,73,87,98,124,127,143,164,197,206,221,234,238,243,256],"effect":[9],"Panax":[12],"notoginseng":[13],"ethanol":[14],"extract":[15],"(PNEE)":[16],"on":[17],"regulation":[19],"human":[21,41],"colorectal":[22],"cancer":[23],"(CRC)":[24],"metastasis.":[25],"migratory,":[27],"invasive,":[28],"and":[29,32,56,81,132,170,177,240,252,254],"adhesive":[30],"abilities":[31,58],"expression":[34,80,84,257],"metastasis-associated":[36,259],"regulatory":[37],"molecules":[38],"in":[39,51,115,180],"cultured":[40],"CRC":[42],"cells":[43,61,71,108,117,146,158,218,246],"(HCT-116)":[44],"treated":[45,159,219],"with":[46,72,86,97,123,147,160,163,174,205,220],"PNEE":[48,65,74,99,165,207,222,239,244],"were":[49,62,118,137],"analyzed":[50],"study.":[53],"migratory":[55],"invasive":[57],"HCT-116":[60,70,104,116,157,217],"reduced":[63,225],"after":[64,203],"treatment.":[66],"incubation":[68,204],"for":[75,208],"24":[76,209],"h":[77],"decreased":[78,103,120,139],"MMP-9":[79],"increased":[82,202],"E-cadherin":[83],"compared":[85,173],"control":[88],"group.":[89],"adhesion":[91,105,134,253],"reaction":[92],"assay":[93,214],"indicated":[94,155,215],"that":[95,156,216,242],"treatment":[96,122,141],"led":[100],"significantly":[102,119,138,224],"endothelial":[107,145,199],"(EA.hy926":[109],"cells).":[110],"integrin-1":[112],"protein":[113,128],"levels":[114,129,226],"following":[121],"PNEE.":[125,148],"Similarly,":[126],"E-selectin":[131],"intercellular":[133],"molecule-1":[135],"(ICAM-1)":[136],"by":[140,247],"EA.hy926":[144,198],"A":[149,211],"scanning":[150],"electron":[151],"microscope":[152],"(SEM)":[153],"examination":[154],"LPS":[161],"combined":[162],"had":[166],"a":[167,186],"less":[168],"flattened":[169],"retracted":[171],"shape":[172,181],"LPS-treated":[175],"cells,":[176],"change":[179],"found":[183],"be":[185],"phenomenon":[187],"extravasation":[189],"invasion.":[190],"transepithelial":[192],"electrical":[193],"resistance":[194],"(TEER)":[195],"cell":[200,249],"monolayer":[201],"h.":[210],"cell-cell":[212],"permeability":[213],"displayed":[223],"phosphorylated":[228],"VE-cadherin":[229],"(p-VE-cadherin).":[230],"These":[231],"results":[232],"demonstrate":[233],"antimetastatic":[235],"properties":[236],"show":[241],"affects":[245],"inhibiting":[248],"migration,":[250],"invasion,":[251],"regulating":[255],"signaling":[260],"molecules.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}