{"id":"https://openalex.org/W2395834338","doi":null,"title":"A systematic search for a bipolar predisposing locus on chromosome 5.","display_name":"A systematic search for a bipolar predisposing locus on chromosome 5.","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2395834338","mag":"2395834338","pmid":"https://pubmed.ncbi.nlm.nih.gov/1632891"},"language":"en","primary_location":{"id":"pmid:1632891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041991034","display_name":"Sevilla D. Detera\u2010Wadleigh","orcid":"https://orcid.org/0000-0002-8549-0066","observed_orcids":["https://orcid.org/0000-0002-8549-0066"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S D Detera-Wadleigh","raw_affiliation_strings":["Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012998944","display_name":"Wade H. Berrettini","orcid":"https://orcid.org/0000-0001-8445-5165","observed_orcids":["https://orcid.org/0000-0001-8445-5165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W H Berrettini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076029384","display_name":"Lynn R. Goldin","orcid":"https://orcid.org/0000-0001-7350-446X","observed_orcids":["https://orcid.org/0000-0001-7350-446X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L R Goldin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050979549","display_name":"Maria M. Martinez","orcid":"https://orcid.org/0000-0003-2180-4537","observed_orcids":["https://orcid.org/0000-0003-2180-4537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Martinez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110171086","display_name":"W T Hsieh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W T Hsieh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086522997","display_name":"Margret R. Hoehe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Hoehe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076267766","display_name":"Ignacio Enc\u0131\u0301o","orcid":"https://orcid.org/0000-0003-1732-1989","observed_orcids":["https://orcid.org/0000-0003-1732-1989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I J Encio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063450243","display_name":"D. Coffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Coffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010331950","display_name":"Denise Y. Rollins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Y Rollins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037622916","display_name":"David Muniec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Muniec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7202,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90553407,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4","first_page":"219","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chromosome-5","display_name":"chromosome 5","score":0.8650000095367432},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.9470000267028809},{"id":"https://openalex.org/keywords/schizoaffective-disorder","display_name":"schizoaffective disorder","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pedigree-analysis","display_name":"pedigree analysis","score":0.5550000071525574},{"id":"https://openalex.org/keywords/lod-score","display_name":"lod score","score":0.8600000143051147},{"id":"https://openalex.org/keywords/multipoint-analysis","display_name":"multipoint analysis","score":0.6290000081062317},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phenocopy","display_name":"phenocopy","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C12387725","wikidata":"https://www.wikidata.org/wiki/Q937024","display_name":"Phenocopy","level":4,"score":0.8808945417404175},{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.8125556707382202},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.7381142377853394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.708238959312439},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.6711814403533936},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6434544324874878},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5773957371711731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5167036056518555},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5090270042419434},{"id":"https://openalex.org/C190789776","wikidata":"https://www.wikidata.org/wiki/Q767511","display_name":"Genetic marker","level":3,"score":0.446725457906723},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.43815943598747253},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4136166274547577},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.4133650064468384},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28995704650878906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16924023628234863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16803526878356934},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.08795639872550964},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.056951314210891724},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.05463835597038269}],"mesh":[{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002895","descriptor_name":"Chromosomes, Human, Pair 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1632891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"},{"id":"mag:2395834338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090657055","https://openalex.org/W2072509409","https://openalex.org/W2107242691","https://openalex.org/W2024324966","https://openalex.org/W77030747","https://openalex.org/W1967318382","https://openalex.org/W1984086447","https://openalex.org/W2096581460","https://openalex.org/W2037873735","https://openalex.org/W2156581173"],"abstract_inverted_index":{"Chromosome":[0],"5":[1,149],"markers":[2],"spanning":[3],"the":[4,7,76,84,100,143],"pter":[5],"to":[6,11,14,104,155],"qter":[8],"were":[9,22,30,37,45,94,122],"used":[10],"examine":[12],"linkage":[13,103,154],"bipolar":[15,79,156],"illness":[16,80],"in":[17,24,138],"14":[18],"pedigrees.":[19],"Twenty-four":[20],"loci":[21],"examined":[23],"237":[25],"individuals,":[26],"of":[27,56,62,67,73,102,108,115,129,147],"whom":[28],"69":[29],"either":[31],"bipolars":[32],"or":[33],"schizoaffectives.":[34],"Marker":[35],"genotypes":[36],"determined":[38],"for":[39,125,153],"each":[40,92],"individual":[41],"and":[42,69],"lod":[43,86,120],"scores":[44,87,121],"calculated":[46,123],"under":[47],"a":[48,53,58,64,70],"dominant":[49],"disease":[50,59,105],"model":[51],"with":[52,91],"maximum":[54],"penetrance":[55],"85%,":[57],"gene":[60],"frequency":[61],"0.015,":[63],"variable":[65],"age":[66],"onset,":[68],"phenocopy":[71],"rate":[72],"0.001.":[74],"Under":[75],"assumption":[77],"that":[78,137],"is":[81],"genetically":[82],"homogeneous,":[83],"total":[85],"from":[88],"all":[89],"pedigrees":[90],"marker":[93],"uniformly":[95],"lower":[96],"than":[97],"-2.0,":[98],"suggesting":[99],"absence":[101],"at":[106],"any":[107],"these":[109],"loci.":[110],"Multipoint":[111],"analysis":[112],"allowed":[113],"exclusion":[114],"intervals":[116],"between":[117],"markers.":[118],"When":[119],"allowing":[124],"heterogeneity,":[126],"no":[127],"subset":[128],"linked":[130],"families":[131],"was":[132],"found.":[133],"These":[134],"results":[135],"indicate":[136],"our":[139],"pedigree":[140],"series":[141],"almost":[142],"entire":[144],"mapped":[145],"region":[146],"chromosome":[148],"can":[150],"be":[151],"excluded":[152],"illness.":[157]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
