{"id":"https://openalex.org/W2395833453","doi":null,"title":"[Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer].","display_name":"[Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer].","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2395833453","mag":"2395833453","pmid":"https://pubmed.ncbi.nlm.nih.gov/19106592"},"language":"ja","primary_location":{"id":"pmid:19106592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19106592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112096760","display_name":"Kazuhiko Yoshimatsu","orcid":"https://orcid.org/0000-0001-7901-8374","observed_orcids":["https://orcid.org/0000-0001-7901-8374"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Yoshimatsu","raw_affiliation_strings":["Dept. of Surgery, Tokyo Women's Medical University, Medical Center East"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, Tokyo Women's Medical University, Medical Center East","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109336895","display_name":"Hajime Yokomizo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Yokomizo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061270953","display_name":"Gakuji Osawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gakuji Osawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086768780","display_name":"Takashi Fujimoto","orcid":"https://orcid.org/0000-0002-9966-6202","observed_orcids":["https://orcid.org/0000-0002-9966-6202","https://orcid.org/0000-0002-0295-7995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Fujimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073746318","display_name":"Taisuke Otani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taisuke Otani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000823360","display_name":"Takuya Tsunoda","orcid":"https://orcid.org/0000-0002-6416-8211","observed_orcids":["https://orcid.org/0000-0002-6416-8211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuya Tsunoda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101940701","display_name":"Yusuke Nakamura","orcid":"https://orcid.org/0009-0009-8461-749X","observed_orcids":["https://orcid.org/0009-0009-8461-749X","https://orcid.org/0000-0003-2956-382X","https://orcid.org/0000-0002-2310-0587","https://orcid.org/0000-0003-4425-4216","https://orcid.org/0009-0004-6320-7030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yusuke Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108587373","display_name":"Kenji Ogawa","orcid":"https://orcid.org/0000-0002-4247-6862","observed_orcids":["https://orcid.org/0000-0002-4247-6862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenji Ogawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.33602248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"12","first_page":"2268","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/montanide-isa-51","display_name":"Montanide ISA 51","score":0.9480000138282776},{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.8510000109672546},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.7630000114440918},{"id":"https://openalex.org/keywords/para-aortic-lymph-node-metastasis","display_name":"para-aortic lymph node metastasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/sigmoid-colon-cancer","display_name":"sigmoid colon cancer","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9078574180603027},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7386403679847717},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6251529455184937},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5704684853553772},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.559705376625061},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5579149127006531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5501275658607483},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5311405062675476},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5075916051864624},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2660549283027649},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1933833360671997},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17664164304733276},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059871","descriptor_name":"HLA-A24 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19106592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19106592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},{"id":"mag:2395833453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19106592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3080855752","https://openalex.org/W2062173928","https://openalex.org/W2113364379","https://openalex.org/W2002686369","https://openalex.org/W2012468683","https://openalex.org/W2153876458","https://openalex.org/W2793266104","https://openalex.org/W2593057183","https://openalex.org/W2965262419","https://openalex.org/W2146747550"],"abstract_inverted_index":{"Phase":[0],"I":[1],"study":[2,25,50],"of":[3,23,34,37,56],"combination":[4,45],"therapy":[5],"with":[6,40,46,62,74,82,113],"peptide":[7,57,75],"vaccine":[8],"and":[9,31,79],"anti-cancer":[10],"drug":[11],"for":[12,116],"colorectal":[13],"cancer":[14],"has":[15,106],"been":[16,107],"performed":[17],"in":[18,44],"our":[19],"hospital.":[20],"The":[21,49],"purpose":[22],"this":[24,114],"was":[26,52],"to":[27,109],"evaluate":[28],"the":[29],"safety":[30],"immune":[32],"response":[33],"different":[35],"dose":[36,54],"RNF43-721":[38],"emulsified":[39],"Montanide":[41],"ISA":[42],"51":[43],"S-1/CPT-11":[47,83],"chemotherapy.":[48,84],"design":[51],"a":[53,103],"escalation":[55],"(0.5,":[58],"1.0,":[59],"3.0":[60],"mg)":[61],"three":[63],"patients'":[64],"cohort.":[65],"Nine":[66],"patients":[67,71],"were":[68,72,86],"enrolled.":[69],"All":[70],"treated":[73],"subcutaneously":[76],"every":[77],"week":[78],"two":[80],"courses":[81],"Vaccinations":[85],"well":[87],"tolerated":[88],"without":[89],"any":[90],"major":[91],"adverse":[92],"events.":[93],"Immunological":[94],"reactions":[95],"are":[96],"not":[97],"analyzed":[98],"yet.":[99],"We":[100],"herein":[101],"report":[102],"case":[104],"who":[105],"evaluated":[108],"be":[110],"long":[111],"SD":[112],"intervention":[115],"para-aortic":[117],"LN":[118],"metastasis":[119],"from":[120],"sigmoid":[121],"colon":[122],"cancer.":[123]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}