{"id":"https://openalex.org/W2395792408","doi":null,"title":"Hypoxia and development of interneurones of the rat hippocampus.","display_name":"Hypoxia and development of interneurones of the rat hippocampus.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2395792408","mag":"2395792408","pmid":"https://pubmed.ncbi.nlm.nih.gov/2528767"},"language":"en","primary_location":{"id":"pmid:2528767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2528767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiologia Bohemoslovaca","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007247609","display_name":"Jaroslav Pokorny","orcid":"https://orcid.org/0000-0002-9716-3409","observed_orcids":["https://orcid.org/0000-0002-9716-3409"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J Pokorn\u00fd","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Charles University, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Charles University, Prague","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083873718","display_name":"Y Pecov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Pecov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109323951","display_name":"S Trojan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Trojan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086682644","display_name":"M Langmeier","orcid":"https://orcid.org/0000-0001-6260-0739","observed_orcids":["https://orcid.org/0000-0001-6260-0739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Langmeier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.26462207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"38","issue":"3","first_page":"215","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postnatal-hypoxia","display_name":"postnatal hypoxia","score":0.902999997138977},{"id":"https://openalex.org/keywords/hippocampal-interneurons","display_name":"hippocampal interneurons","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dendritic-morphology","display_name":"dendritic morphology","score":0.7940000295639038},{"id":"https://openalex.org/keywords/interneuron-density","display_name":"interneuron density","score":0.921999990940094},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.8330000042915344},{"id":"https://openalex.org/keywords/stratum-radiatum","display_name":"stratum radiatum","score":0.9890000224113464},{"id":"https://openalex.org/keywords/excitation-inhibition-balance","display_name":"excitation-inhibition balance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hippocampal-development","display_name":"hippocampal development","score":0.7059999704360962},{"id":"https://openalex.org/keywords/morphometrics","display_name":"morphometrics","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7036117315292358},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6575790047645569},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6446448564529419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5446027517318726},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5241649150848389},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.4472787380218506},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4325970411300659},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3635612726211548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3594557046890259},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.31721222400665283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24818778038024902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14383509755134583},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2528767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2528767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiologia Bohemoslovaca","raw_type":"Journal Article"},{"id":"mag:2395792408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2528767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2442200589","https://openalex.org/W2412942559","https://openalex.org/W2396860585","https://openalex.org/W2415611448","https://openalex.org/W2066462712","https://openalex.org/W2027656765","https://openalex.org/W2066483293","https://openalex.org/W2107713038","https://openalex.org/W1964590899","https://openalex.org/W7054523608"],"abstract_inverted_index":{"Interneuronal":[0],"connections":[1],"are":[2,14,93],"an":[3],"important":[4],"component":[5],"of":[6,10,42,45,58,104,118,121,125],"the":[7,11,43,59,71,78,89,102,105,110,119,122],"integration":[8],"circuits":[9],"hippocampus.":[12],"They":[13],"formed":[15],"mostly":[16],"postnatally,":[17],"i.e.":[18],"in":[19,52,70,77,88,109],"a":[20,37,98],"phase":[21],"when":[22],"their":[23],"development":[24],"can":[25,114],"be":[26],"strongly":[27],"influenced":[28],"by":[29],"external":[30],"environmental":[31],"factors.":[32],"In":[33],"model":[34],"postnatal":[35],"hypoxia,":[36],"morphometric":[38],"analysis":[39],"showed":[40],"reduction":[41],"number":[44],"dendritic":[46],"segments":[47],"(chiefly":[48],"3rd":[49],"order":[50],"segments)":[51],"18-day-old":[53],"rats.":[54],"The":[55],"total":[56],"length":[57,66],"dendrites":[60],"was":[61,74,85],"unaltered,":[62],"but":[63,81],"mean":[64],"segment":[65],"increased.":[67],"Interneuron":[68],"density":[69,84],"experimental":[72],"animals":[73],"higher,":[75],"especially":[76],"stratum":[79],"radiatum,":[80],"pyramidal":[82],"cell":[83],"lower":[86],"than":[87],"controls.":[90],"These":[91],"findings":[92],"evidence":[94],"that":[95],"hypoxia":[96],"has":[97],"complex":[99],"effect":[100],"on":[101],"microstructure":[103],"hippocampus":[106],"and":[107,127],"that,":[108],"long":[111],"run,":[112],"it":[113],"lead":[115],"to":[116],"impairment":[117],"balance":[120],"elementary":[123],"processes":[124],"excitation":[126],"inhibition.":[128]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}