{"id":"https://openalex.org/W2395762755","doi":null,"title":"Pharmacotherapy of adolescent major depression: beyond TCAs.","display_name":"Pharmacotherapy of adolescent major depression: beyond TCAs.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2395762755","mag":"2395762755","pmid":"https://pubmed.ncbi.nlm.nih.gov/2196629"},"language":"en","primary_location":{"id":"pmid:2196629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2196629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology bulletin","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101747001","display_name":"Neal D. Ryan","orcid":"https://orcid.org/0000-0003-1335-8426","observed_orcids":["https://orcid.org/0000-0003-1335-8426"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N D Ryan","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101747001"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":2.8238,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90966995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"26","issue":"1","first_page":"75","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10182","display_name":"Child and Adolescent Psychosocial and Emotional Development","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antidepressant-treatment","display_name":"antidepressant treatment","score":0.7900000214576721},{"id":"https://openalex.org/keywords/placebo-responders","display_name":"placebo responders","score":0.6650000214576721},{"id":"https://openalex.org/keywords/open-label-study","display_name":"open-label study","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7443662881851196},{"id":"https://openalex.org/C2779657639","wikidata":"https://www.wikidata.org/wiki/Q908843","display_name":"Tricyclic antidepressant","level":4,"score":0.7415232062339783},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.7036489248275757},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6782259941101074},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.6462430953979492},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.56548011302948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5598101615905762},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5390993356704712},{"id":"https://openalex.org/C2992459003","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo response","level":4,"score":0.5329030156135559},{"id":"https://openalex.org/C2781210005","wikidata":"https://www.wikidata.org/wiki/Q6738337","display_name":"Major depressive episode","level":3,"score":0.5047558546066284},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.4756854772567749},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4497515857219696},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32244786620140076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2764394283294678},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.10857763886451721},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.07855275273323059},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000297","descriptor_name":"Psychology, Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2196629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2196629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology bulletin","raw_type":"Journal Article"},{"id":"mag:2395762755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2196629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1814545769","https://openalex.org/W2170153793","https://openalex.org/W2008693468","https://openalex.org/W2034063477","https://openalex.org/W2034900956","https://openalex.org/W2131237665","https://openalex.org/W2059073970","https://openalex.org/W1980879074","https://openalex.org/W1964128529","https://openalex.org/W1964727785"],"abstract_inverted_index":{"To":[0],"date,":[1],"controlled":[2],"studies":[3,49,79],"of":[4,9,18,24,37,43,47,53,56,62,80],"tricyclic":[5],"antidepressant":[6,82],"(TCA)":[7],"treatment":[8],"adolescent":[10,28],"major":[11,29],"depression":[12,30],"have":[13],"failed":[14],"to":[15,33,58],"demonstrate":[16],"efficacy":[17],"these":[19],"compounds":[20],"despite":[21],"multiple":[22],"lines":[23],"evidence":[25],"suggesting":[26],"that":[27],"is":[31,50],"related":[32],"the":[34,38,45,54,69],"adult":[35],"form":[36],"disorder.":[39],"One":[40],"possible":[41],"means":[42],"increasing":[44],"power":[46],"such":[48],"explored:":[51],"examination":[52],"pattern":[55],"response":[57],"medication":[59,66],"and":[60,74,88],"separation":[61],"placebo":[63],"responders":[64,67],"from":[65],"using":[68],"technique":[70],"proposed":[71],"by":[72],"Quitkin":[73],"colleagues":[75],"(1984).":[76],"Open":[77],"label":[78],"nontricyclic":[81],"agents":[83],"in":[84,96],"adolescents":[85],"are":[86,90],"reviewed,":[87],"suggestions":[89],"made":[91],"for":[92],"future":[93],"pharmacological":[94],"trials":[95],"this":[97],"population.":[98]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}