{"id":"https://openalex.org/W2395747602","doi":"https://doi.org/10.1152/jappl.1989.66.4.1905","title":"Quantification of regional V/Q ratios in humans by use of PET. II. Procedure and normal values","display_name":"Quantification of regional V/Q ratios in humans by use of PET. II. Procedure and normal values","publication_year":1989,"publication_date":"1989-04-01","ids":{"openalex":"https://openalex.org/W2395747602","doi":"https://doi.org/10.1152/jappl.1989.66.4.1905","mag":"2395747602","pmid":"https://pubmed.ncbi.nlm.nih.gov/2786523"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1989.66.4.1905","doi":"https://doi.org/10.1152/jappl.1989.66.4.1905","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1989.66.4.1905","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113831913","display_name":"Christopher G. Rhodes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. G. Rhodes","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520341","display_name":"S. Valind","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. O. Valind","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031786155","display_name":"Lars H. Brudin","orcid":"https://orcid.org/0000-0002-6278-1362","observed_orcids":["https://orcid.org/0000-0002-6278-1362"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. H. Brudin","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065329704","display_name":"Per Wollmer","orcid":"https://orcid.org/0000-0003-2448-9931","observed_orcids":["https://orcid.org/0000-0003-2448-9931"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. E. Wollmer","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030656061","display_name":"Terry Jones","orcid":"https://orcid.org/0000-0002-8852-6837","observed_orcids":["https://orcid.org/0000-0002-8852-6837"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Jones","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056610041","display_name":"P. D. Buckingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. D. Buckingham","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112173892","display_name":"J. M. B. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. M. Hughes","raw_affiliation_strings":["Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Cyclotron Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8093,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.82819335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"66","issue":"4","first_page":"1905","last_page":"1913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventilation-perfusion-mismatch","display_name":"ventilation-perfusion mismatch","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pulmonary-blood-flow","display_name":"pulmonary blood flow","score":0.5899999737739563},{"id":"https://openalex.org/keywords/pulmonary-ventilation","display_name":"pulmonary ventilation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/supine-position","display_name":"supine position","score":0.6200000047683716},{"id":"https://openalex.org/keywords/dependent-lung-regions","display_name":"dependent lung regions","score":0.7910000085830688},{"id":"https://openalex.org/keywords/smokers","display_name":"smokers","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.8529649972915649},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.733238697052002},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5186323523521423},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.4969766438007355},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4866946041584015},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4470609128475189},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4427070915699005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41988489031791687},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.41086477041244507},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2499907910823822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22422397136688232},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17658475041389465},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014692","descriptor_name":"Ventilation-Perfusion Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1989.66.4.1905","doi":"https://doi.org/10.1152/jappl.1989.66.4.1905","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1989.66.4.1905","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:2786523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2786523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2105652385","https://openalex.org/W2395886740","https://openalex.org/W2155105246","https://openalex.org/W7096767722","https://openalex.org/W1856988603","https://openalex.org/W2161778294","https://openalex.org/W2033860876","https://openalex.org/W1833554327","https://openalex.org/W1968674621","https://openalex.org/W2019261076"],"abstract_inverted_index":{"Regional":[0],"measurements":[1,74],"of":[2,26,58,65,106,124,140,162,172,194,207],"tissue":[3],"isotope":[4],"concentration,":[5],"made":[6,75],"using":[7],"positron":[8],"emission":[9],"tomography":[10],"(PET),":[11],"allow":[12],"tracer":[13],"models":[14],"to":[15,22,47,99,137],"be":[16],"used":[17],"in":[18,53,76,110,164,170,218,228,237],"a":[19,45,86,100,159,184,198],"quantitative":[20],"manner":[21],"provide":[23],"topographic":[24],"distributions":[25],"many":[27],"structural":[28],"and":[29,60,71,130,222],"functional":[30],"parameters,":[31],"each":[32],"derived":[33],"for":[34],"the":[35,61,104,107,111,118,165,173,195,211,229],"same":[36],"well-defined":[37],"lung":[38,88,132,189,213,239],"element.":[39],"In":[40],"this":[41],"paper":[42],"we":[43],"describe":[44],"technique":[46],"measure":[48],"regional":[49],"ventilation-perfusion":[50],"ratios":[51],"(V/Q),":[52],"absolute":[54],"units,":[55],"by":[56],"use":[57],"PET":[59],"continuous":[62],"intravenous":[63],"infusion":[64],"an":[66],"inert":[67],"gas":[68],"isotope,":[69],"13N,":[70],"report":[72],"on":[73],"12":[77,119],"normal":[78,219],"subjects":[79,174,196],"(4":[80],"smokers).":[81],"Data":[82],"were":[83],"obtained":[84],"from":[85,135],"single":[87],"section":[89],"(slice":[90],"thickness,":[91],"1.7":[92],"cm":[93],"full":[94],"width":[95],"at":[96,103,210],"half-maximum":[97],"response":[98],"line":[101],"source)":[102],"level":[105],"right":[108,129],"ventricle":[109],"supine":[112,230],"posture":[113],"during":[114],"quiet":[115],"breathing.":[116],"For":[117],"subjects,":[120,220],"volume-weighted":[121],"mean":[122],"values":[123],"V/Q,":[125],"averaged":[126],"over":[127],"individual":[128],"left":[131],"fields,":[133],"ranged":[134],"0.50":[136],"1.29.":[138],"Analysis":[139],"these":[141],"means":[142],"showed":[143,183],"no":[144],"difference":[145,177],"between":[146],"lungs:":[147],"right,":[148],"0.80":[149],"+/-":[150,155],"0.23":[151],"SD;":[152],"left,":[153],"0.76":[154],"0.20":[156],"SD.":[157],"Topographically,":[158],"systematic":[160],"fall":[161],"V/Q":[163,201,209],"ventrodorsal":[166,176,200],"direction":[167],"was":[168],"observed":[169],"eight":[171],"(mean":[175],"0.39,":[178],"range":[179],"0.19-0.90),":[180],"whereas":[181],"two":[182],"clear":[185],"increase":[186],"toward":[187],"dependent":[188,238],"regions":[190,206],"(range":[191],"0.16-0.26).":[192],"Seven":[193],"with":[197],"falling":[199],"gradient":[202],"also":[203],"exhibited":[204],"discrete":[205],"low":[208],"dorsal":[212],"border.":[214],"We":[215],"conclude":[216],"that,":[217],"ventilation":[221],"perfusion":[223],"are":[224],"generally":[225],"well":[226],"matched":[227],"posture,":[231],"but":[232],"isolated":[233],"mismatching":[234],"often":[235],"occurs":[236],"regions.":[240]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}