{"id":"https://openalex.org/W2395599395","doi":null,"title":"Validation of a microbiological method using Acholeplasma laidlawii for assessing performance of microporous membranes for mycoplasma clearance.","display_name":"Validation of a microbiological method using Acholeplasma laidlawii for assessing performance of microporous membranes for mycoplasma clearance.","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2395599395","mag":"2395599395","pmid":"https://pubmed.ncbi.nlm.nih.gov/20158050"},"language":"en","primary_location":{"id":"pmid:20158050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20158050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PDA journal of pharmaceutical science and technology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052732225","display_name":"Karen Cronholm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Cronholm","raw_affiliation_strings":["Bioprocess R&D, Millipore Corporation, 80 Ashby Road, Bedford, MA 01730, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioprocess R&D, Millipore Corporation, 80 Ashby Road, Bedford, MA 01730, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052343945","display_name":"Shawn Bates","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shawn Bates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002743645","display_name":"Nhung Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nhung Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069390280","display_name":"Anne Leahy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Leahy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Blanchard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Blanchard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001924649","display_name":"Kerry Roche Lentine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerry Roche Lentine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6642,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72734134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"5","first_page":"438","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10197","display_name":"Membrane Separation Technologies","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10197","display_name":"Membrane Separation Technologies","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.16099999845027924,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acholeplasma-laidlawii","display_name":"Acholeplasma laidlawii","score":0.925000011920929},{"id":"https://openalex.org/keywords/microporous-membranes","display_name":"microporous membranes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/biopharmaceutical-manufacturing","display_name":"biopharmaceutical manufacturing","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bubble-point","display_name":"bubble point","score":0.6769999861717224},{"id":"https://openalex.org/keywords/microbial-contamination-control","display_name":"microbial contamination control","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.5664832592010498},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5610712766647339},{"id":"https://openalex.org/C2778838687","wikidata":"https://www.wikidata.org/wiki/Q210975","display_name":"Mycoplasma","level":2,"score":0.5416785478591919},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.440256804227829},{"id":"https://openalex.org/C128489963","wikidata":"https://www.wikidata.org/wiki/Q1187724","display_name":"Filtration (mathematics)","level":2,"score":0.4169306457042694},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3871912658214569},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.359103798866272},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3509792685508728},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33134347200393677},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3098912835121155},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.232123464345932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22315296530723572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19630327820777893},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18744084239006042},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.18036282062530518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13035869598388672},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12513059377670288},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10792362689971924},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000128","descriptor_name":"Acholeplasma laidlawii","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001431","descriptor_name":"Bacteriological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008851","descriptor_name":"Micropore Filters","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D009174","descriptor_name":"Mycoplasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20158050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20158050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PDA journal of pharmaceutical science and technology","raw_type":"Journal Article"},{"id":"mag:2395599395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20158050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.53329998254776},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1600538013","https://openalex.org/W1687604884","https://openalex.org/W1856219842","https://openalex.org/W1884472013","https://openalex.org/W2096718691","https://openalex.org/W2236392989","https://openalex.org/W2336339044"],"related_works":["https://openalex.org/W2148995011","https://openalex.org/W4383874617","https://openalex.org/W2184998277","https://openalex.org/W2027968716","https://openalex.org/W7150839540","https://openalex.org/W2783349897","https://openalex.org/W2572486899","https://openalex.org/W2948711455","https://openalex.org/W2154149273","https://openalex.org/W2056863360"],"abstract_inverted_index":{"While":[0],"no":[1],"recognized":[2,40],"industry":[3,44],"standard":[4],"currently":[5],"exists":[6],"for":[7],"mycoplasma":[8,33],"clearance":[9,34],"testing":[10,35],"of":[11,48,56,68,77,83,86,92,111,123,137,147],"membrane":[12,20,103,148],"filters,":[13],"several":[14],"methods":[15,122],"have":[16],"been":[17],"used":[18,150],"by":[19],"manufacturers":[21],"and":[22,36,96,120,133],"contract":[23],"test":[24,121,129],"laboratories.":[25],"This":[26,139],"validation":[27,38,113],"exercise":[28,114],"documents":[29],"one":[30],"approach":[31],"to":[32,100,143],"incorporates":[37],"guidelines":[39],"in":[41,66,134,151],"the":[42,53,80,98,112,117,124,145],"biopharmaceutical":[43,152],"today.":[45],"The":[46,109],"benefits":[47],"this":[49],"method":[50,140],"are":[51,130],"(1)":[52],"consistent":[54,81],"production":[55],"small":[57],"monodisperse":[58],"cells,":[59],"0.37":[60],"x":[61,70],"0.41":[62],"microm,":[63],"at":[64],"titers":[65],"excess":[67],"1":[69],"10(9)":[71],"CFU":[72],"mL(-1)":[73],"within":[74],"20-24":[75],"h":[76],"incubation;":[78],"(2)":[79],"detection":[82],"low":[84],"levels":[85],"Acholeplasma":[87],"laidlawii":[88,126],"with":[89,105],"an":[90],"absence":[91],"false":[93],"negative":[94],"results;":[95],"(3)":[97],"ability":[99],"distinguish":[101],"among":[102],"filters":[104,149],"different":[106],"bubble":[107],"points.":[108],"results":[110],"demonstrate":[115],"that":[116],"equipment,":[118],"materials,":[119],"A.":[125],"filter":[127],"challenge":[128],"suitably":[131],"understood":[132],"a":[135],"state":[136],"control.":[138],"is":[141],"appropriate":[142],"characterize":[144],"performance":[146],"applications.":[153]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
