{"id":"https://openalex.org/W2395591435","doi":null,"title":"Anti-idiotype to monoclonal anti-swine SLA antibody detects a common idiotype shared by mouse anti-SLA sera and elicits an anti-SLA activity.","display_name":"Anti-idiotype to monoclonal anti-swine SLA antibody detects a common idiotype shared by mouse anti-SLA sera and elicits an anti-SLA activity.","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W2395591435","mag":"2395591435","pmid":"https://pubmed.ncbi.nlm.nih.gov/3089919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453115"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453115","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453115","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453115","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110045264","display_name":"R Rabinowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rabinowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042236941","display_name":"Mark D. Pescovitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Pescovitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073338357","display_name":"David H. Sachs","orcid":"https://orcid.org/0000-0001-9588-8580","observed_orcids":["https://orcid.org/0000-0001-9588-8580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Sachs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4307,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61127044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":"4","first_page":"607","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.7710000276565552},{"id":"https://openalex.org/keywords/xenoantisera","display_name":"xenoantisera","score":0.7509999871253967},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tolerance-pharmacology-and-immunology","display_name":"tolerance (pharmacology and immunology)","score":0.3880000114440918},{"id":"https://openalex.org/keywords/variable-region-genes","display_name":"variable region genes","score":0.722000002861023},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.8157624006271362},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7251847386360168},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.6860558390617371},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6495612859725952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5998706817626953},{"id":"https://openalex.org/C2910082366","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Immunoglobulin Idiotypes","level":5,"score":0.5137258768081665},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5051067471504211},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4885343313217163},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.48040202260017395},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.37476682662963867},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3350769281387329},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19888237118721008},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06309199333190918}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1453115","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453115","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:3089919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3089919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:2395591435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3089919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453115","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453115","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1504492615","https://openalex.org/W1521286109","https://openalex.org/W1562079541","https://openalex.org/W1625897096","https://openalex.org/W1883188249","https://openalex.org/W1916871702","https://openalex.org/W1989949042","https://openalex.org/W1997881863","https://openalex.org/W2000696784","https://openalex.org/W2009473574","https://openalex.org/W2011199011","https://openalex.org/W2013227185","https://openalex.org/W2021615388","https://openalex.org/W2031686936","https://openalex.org/W2042230752","https://openalex.org/W2043844341","https://openalex.org/W2068512144","https://openalex.org/W2084093106","https://openalex.org/W2089747719","https://openalex.org/W2104965258","https://openalex.org/W2107106791","https://openalex.org/W2132840519","https://openalex.org/W2151587543"],"related_works":["https://openalex.org/W1989253527","https://openalex.org/W2072345275","https://openalex.org/W2028616301","https://openalex.org/W2132840519","https://openalex.org/W1585991687","https://openalex.org/W1507798367","https://openalex.org/W1995642728","https://openalex.org/W1519616856","https://openalex.org/W1888650860","https://openalex.org/W1613927213"],"abstract_inverted_index":{"Heterologous":[0],"anti-idiotypic":[1,97,132,180],"reagents":[2,29,98],"have":[3],"been":[4],"prepared":[5],"against":[6],"a":[7,147],"BALB/c":[8,35,69,100,151],"anti-swine":[9],"MHC":[10,127],"(SLAd)":[11],"monoclonal":[12],"antibody":[13,138],"(74-11-10)":[14],"in":[15,34,64,93,159],"order":[16],"to":[17,30,49,84,99,113,135,172],"test":[18],"for":[19],"possible":[20],"interspecies":[21],"idiotypic":[22],"cross-reactions":[23],"of":[24,53,67,88,96,105,118,129,150,156,170,186,191],"anti-MHC":[25],"antibodies.":[26,153],"Using":[27],"these":[28],"examine":[31],"xenoantisera":[32],"produced":[33],"mice":[36,70,101],"immunized":[37,71,162],"with":[38,72,131,163,179],"swine":[39,73,120,122],"SLAdd":[40,114],"peripheral":[41],"blood":[42],"lymphocytes,":[43],"all":[44],"animals":[45],"tested":[46],"were":[47,79],"found":[48],"express":[50,173],"detectable":[51,86,103],"levels":[52,87,104],"the":[54,89,124,168,174,184,192],"74-11-10":[55,90,106,145,157,175],"idiotype":[56,149],"(Id).":[57],"The":[58,92,154],"Id":[59,107,158,176],"could":[60],"also":[61,80],"be":[62,183],"detected":[63],"one":[65,160],"out":[66],"five":[68],"SLAcc":[74,164],"PBL.":[75,115],"Swine":[76],"anti-SLAdd":[77,152],"alloantibodies":[78],"tested,":[81],"but":[82],"failed":[83,134],"show":[85],"Id.":[91],"vivo":[94],"administration":[95],"induced":[102],"positive":[108],"antibodies":[109,133,181],"that":[110,144,167],"bound":[111],"specifically":[112],"Similar":[116],"treatment":[117,178],"SLAgg":[119],"(recombinant":[121],"expressing":[123],"class":[125],"I":[126],"molecules":[128],"c)":[130],"induce":[136],"anti-SLAd":[137],"activity.":[139],"These":[140],"results":[141],"thus":[142],"indicate":[143],"represents":[146],"shared":[148],"presence":[155],"mouse":[161],"PBL":[165],"suggests":[166],"failure":[169],"pigs":[171],"following":[177],"may":[182],"result":[185],"tolerance":[187],"rather":[188],"than":[189],"absence":[190],"relevant":[193],"variable":[194],"region":[195],"gene(s).":[196]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}