{"id":"https://openalex.org/W2395580402","doi":null,"title":"The identification and partial characterization of a human mononuclear cell-derived neutrophil chemotactic factor apparently distinct from IL-1, IL-2, GM-CSF, TNF and IFN-gamma.","display_name":"The identification and partial characterization of a human mononuclear cell-derived neutrophil chemotactic factor apparently distinct from IL-1, IL-2, GM-CSF, TNF and IFN-gamma.","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2395580402","mag":"2395580402","pmid":"https://pubmed.ncbi.nlm.nih.gov/3292407","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384946"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105301527","display_name":"Piero Maestrelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Maestrelli","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, Brompton Hospital, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, Brompton Hospital, London, U.K","institution_ids":["https://openalex.org/I4210096640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088995573","display_name":"Tsai Jj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Tsai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074378770","display_name":"Oliver Cromwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Cromwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050094214","display_name":"A B Kay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Kay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6602,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.93781095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"64","issue":"2","first_page":"219","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-chemotactic-factor","display_name":"neutrophil chemotactic factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.890999972820282},{"id":"https://openalex.org/keywords/neutrophil-chemoattractants","display_name":"neutrophil chemoattractants","score":0.6779999732971191},{"id":"https://openalex.org/keywords/chemokinesis","display_name":"chemokinesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.4410000145435333},{"id":"https://openalex.org/keywords/granulocyte-monocyte-colony-stimulating-factor","display_name":"granulocyte-monocyte colony-stimulating factor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.921999990940094},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.7099999785423279},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.5070000290870667},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.826651930809021},{"id":"https://openalex.org/C35510296","wikidata":"https://www.wikidata.org/wiki/Q724997","display_name":"Chemokinesis","level":4,"score":0.6468397974967957},{"id":"https://openalex.org/C2780050583","wikidata":"https://www.wikidata.org/wiki/Q2702796","display_name":"Phytohaemagglutinin","level":3,"score":0.5823521018028259},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5633457899093628},{"id":"https://openalex.org/C2776829962","wikidata":"https://www.wikidata.org/wiki/Q4501552","display_name":"Chromatofocusing","level":4,"score":0.5629605650901794},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.5471455454826355},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.502966582775116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48099076747894287},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47168853878974915},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.466397225856781},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4266808331012726},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34502077102661133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33130985498428345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29838013648986816},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29757159948349},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.17230698466300964},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08587417006492615},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07655397057533264}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002847","descriptor_name":"Chromatography, Agarose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1384946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:3292407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3292407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/2508562","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2508562","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2395580402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3292407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W109806090","https://openalex.org/W117390686","https://openalex.org/W1506157243","https://openalex.org/W1510258932","https://openalex.org/W1524801043","https://openalex.org/W1542115737","https://openalex.org/W1593110487","https://openalex.org/W1644494874","https://openalex.org/W1895186915","https://openalex.org/W1926253898","https://openalex.org/W1982213879","https://openalex.org/W2018289835","https://openalex.org/W2019509298","https://openalex.org/W2038891519","https://openalex.org/W2061103764","https://openalex.org/W2072425850","https://openalex.org/W2093107928","https://openalex.org/W2097646128","https://openalex.org/W2100837269","https://openalex.org/W2103685679","https://openalex.org/W2117228071","https://openalex.org/W2140547471","https://openalex.org/W2142688519","https://openalex.org/W2155160447","https://openalex.org/W2413567968","https://openalex.org/W2415343245","https://openalex.org/W4206163632","https://openalex.org/W4313310979","https://openalex.org/W4313313415"],"related_works":["https://openalex.org/W2080740517","https://openalex.org/W7097507271","https://openalex.org/W2001152660","https://openalex.org/W1997025810","https://openalex.org/W2413567968","https://openalex.org/W1975742983","https://openalex.org/W7099172259","https://openalex.org/W127452108","https://openalex.org/W7098564273","https://openalex.org/W7099780936"],"abstract_inverted_index":{"We":[0],"have":[1],"identified":[2],"a":[3,37,45,55,104,128,193],"neutrophil":[4,204],"chemotactic":[5,152],"factor":[6,112,136,142,182],"(NCF)":[7],"in":[8,17,149],"supernatants":[9],"from":[10,197],"human":[11,189],"blood":[12],"mononuclear":[13],"cells":[14],"(MNC)":[15],"cultured":[16],"the":[18,75,172,188],"presence":[19],"of":[20,48,74,100,119,154,160,171,174,177],"phytohaemagglutinin":[21],"(PHA).":[22],"Maximal":[23],"activity":[24,73,173],"was":[25,61,79,87,113,145],"observed":[26],"48":[27],"hr":[28],"after":[29],"culture.":[30],"Following":[31],"gel":[32],"filtration,":[33],"NCF":[34,86,126,158,191],"eluted":[35],"as":[36],"single":[38,56],"major":[39],"peak,":[40],"together":[41],"with":[42,116],"proteins,":[43],"having":[44],"molecular":[46,129],"size":[47,130],"approximately":[49,66],"10,000":[50],"MW.":[51],"The":[52,71,111],"material":[53,78],"gave":[54],"band":[57],"on":[58],"SDS-PAGE":[59],"but":[60],"heterogeneous":[62],"following":[63],"chromatofocusing":[64],"(pIs":[65],"6.8-7.0,":[67],"5.5-6.0":[68],"and":[69,83,94,138,144,165,167,180],"5.0).":[70],"biological":[72],"partially":[76,155],"purified":[77,156],"abolished":[80],"by":[81],"trypsin":[82],"chymotrypsin":[84],"treatment.":[85],"heat":[88],"stable":[89],"(70":[90],"degrees,":[91],"60":[92],"min)":[93],"promoted":[95],"both":[96],"directional":[97],"migration":[98],"(chemotaxis)":[99],"neutrophils":[101],"and,":[102],"to":[103,163,202],"lesser":[105],"extent,":[106],"stimulated":[107],"random":[108],"locomotion":[109],"(chemokinesis).":[110],"not":[114],"associated":[115],"detectable":[117],"amounts":[118],"IL-1,":[120],"IL-2":[121],"or":[122],"interferon-gamma":[123],"(IFN-gamma).":[124],"MNC-derived":[125,157,190],"had":[127,168],"lower":[131],"than":[132],"recombinant":[133,139],"granulocyte-monocyte":[134],"colony-stimulating":[135],"(rGM-CSF)":[137],"tumour":[140],"necrosis":[141],"(rTNF),":[143],"considerably":[146],"more":[147],"active":[148],"chemotaxis.":[150],"Optimal":[151],"concentrations":[153,176],"were":[159],"comparable":[161],"potency":[162],"FMLP":[164],"LTB4":[166],"about":[169],"60%":[170],"optimal":[175],"C5a,":[178],"C5a-des-Arg":[179],"platelet-activating":[181],"(PAF).":[183],"These":[184],"experiments":[185],"indicate":[186],"that":[187],"is":[192],"potent":[194],"chemo-attractant":[195],"distinct":[196],"other":[198],"cytokines":[199],"previously":[200],"reported":[201],"promote":[203],"locomotion.":[205]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}