{"id":"https://openalex.org/W2395555765","doi":"https://doi.org/10.1097/tp.0000000000000896","title":"Research Highlights","display_name":"Research Highlights","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2395555765","doi":"https://doi.org/10.1097/tp.0000000000000896","mag":"2395555765","pmid":"https://pubmed.ncbi.nlm.nih.gov/26308408"},"language":"en","primary_location":{"id":"doi:10.1097/tp.0000000000000896","doi":"https://doi.org/10.1097/tp.0000000000000896","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000000896","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071342347","display_name":"Elmi Muller","orcid":"https://orcid.org/0000-0003-4891-5296","observed_orcids":["https://orcid.org/0000-0003-4891-5296"]},"institutions":[{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Elmi Muller","raw_affiliation_strings":["1 Groote Schuur Hospital Main Road, Observatory Cape Town, Western Cape, South Africa","Groote Schuur Hospital Main Road, Observatory Cape Town, Western Cape, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Groote Schuur Hospital Main Road, Observatory Cape Town, Western Cape, South Africa","institution_ids":["https://openalex.org/I2802258008"]},{"raw_affiliation_string":"Groote Schuur Hospital Main Road, Observatory Cape Town, Western Cape, South Africa","institution_ids":["https://openalex.org/I2802258008"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071342347"],"corresponding_institution_ids":["https://openalex.org/I2802258008"],"apc_list":null,"apc_paid":null,"fwci":1.0687,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.81130106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"99","issue":"9","first_page":"1743","last_page":"1743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/potential-organ-donors","display_name":"potential organ donors","score":0.6240000128746033},{"id":"https://openalex.org/keywords/icu-management","display_name":"intensive care unit management","score":0.8009999990463257},{"id":"https://openalex.org/keywords/organ-procurement-organizations","display_name":"organ procurement organizations","score":0.675000011920929},{"id":"https://openalex.org/keywords/definition-of-death","display_name":"definition of death","score":0.734000027179718},{"id":"https://openalex.org/keywords/donor-suitability","display_name":"donor suitability","score":0.4560000002384186},{"id":"https://openalex.org/keywords/bacterial-meningitis","display_name":"bacterial meningitis","score":0.5210000276565552},{"id":"https://openalex.org/keywords/hiv-testing","display_name":"HIV testing","score":0.46700000762939453},{"id":"https://openalex.org/keywords/hemodynamic-management","display_name":"hemodynamic management","score":0.6119999885559082},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/vasoactive-drugs","display_name":"vasoactive drugs","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pediatric-donors","display_name":"pediatric donors","score":0.5339999794960022},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"organ transplantation","score":0.38499999046325684},{"id":"https://openalex.org/keywords/organ-availability","display_name":"organ availability","score":0.3319999873638153},{"id":"https://openalex.org/keywords/family-support","display_name":"family support","score":0.35600000619888306},{"id":"https://openalex.org/keywords/withdrawal-of-life-sustaining-treatment","display_name":"withdrawal of life-sustaining treatment","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7681061029434204},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6911824941635132},{"id":"https://openalex.org/C2994510829","wikidata":"https://www.wikidata.org/wiki/Q849032","display_name":"Organ donation","level":3,"score":0.5801887512207031},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5172998905181885},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.49009689688682556},{"id":"https://openalex.org/C2775933685","wikidata":"https://www.wikidata.org/wiki/Q1124860","display_name":"Donation","level":2,"score":0.4157383441925049},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.41256552934646606},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.39236071705818176},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2703244686126709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1821504533290863},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003245","descriptor_name":"Consensus Statements as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D009927","descriptor_name":"Tissue and Organ Procurement","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/tp.0000000000000896","doi":"https://doi.org/10.1097/tp.0000000000000896","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000000896","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:26308408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26308408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2229998871","https://openalex.org/W2917147144","https://openalex.org/W2233289629","https://openalex.org/W2995222129","https://openalex.org/W4366203105","https://openalex.org/W7172135156","https://openalex.org/W2913693308","https://openalex.org/W1998476667","https://openalex.org/W7223361677","https://openalex.org/W3029795288"],"abstract_inverted_index":{"Management":[0],"of":[1,10,15,18,42,51,61,120,129,166,221,279,295,307,392,397,406,414,428,466,480,498,518,526,537,552,591,618,632,664],"the":[2,7,34,40,112,127,161,177,218,229,277,280,310,328,404,412,426,451,478,508,587,592,616],"Potential":[3],"Organ":[4,19],"Donor":[5],"in":[6,154,173,246,269,292,325,420,463,535,596,675,688,694],"ICU:":[8],"Society":[9],"Critical":[11],"Care":[12],"Medicine/American":[13],"College":[14],"Chest":[16],"Physicians/Association":[17],"Procurement":[20],"Organizations":[21],"Consensus":[22],"Statement":[23],"This":[24],"consensus":[25],"statement":[26],"provides":[27],"important":[28,113,215],"guidelines":[29],"for":[30,44,57,69,144,150,184,211,238,266,303,319,371,434,441,450,612,646,651,667],"deceased":[31],"donation":[32,116,239,268,321],"to":[33,125,175,179,188,224,227,232,241,244,373,402,461,476,493,520,528,599],"transplant":[35,333],"community.":[36],"The":[37,109,193,253,335,395,482],"document":[38],"defines":[39],"standard":[41],"care":[43,46,182,186,198],"intensive":[45,197],"units":[47],"regarding:":[48],"(1)":[49],"Definitions":[50],"death;":[52],"(2)":[53],"Timing":[54],"and":[55,65,75,92,107,135,187,201,240,289,331,443,457,502,546,558,569,642,678,697],"request":[56,264],"authorization;":[58],"(3)":[59],"Use":[60],"donors":[62,143,223,346,649,654],"with":[63,208,261,276,327,340,366,383,637,655],"malignancies":[64,288],"infections;":[66],"(4)":[67],"Testing":[68],"human":[70,407,619],"immunodeficiency":[71,408],"virus,":[72],"hepatitis":[73],"B":[74],"C;":[76],"(5)":[77],"Hemodynamic":[78,87],"management;":[79],"(6)":[80],"Fluid":[81],"resuscitation;":[82],"(7)":[83],"Vasoactive":[84],"drugs;":[85],"(8)":[86],"monitoring;":[88],"(9)":[89],"Endocrine":[90],"dysfunction":[91],"hormone":[93,499,635],"replacement;":[94],"(10)":[95],"Pediatric":[96],"donor":[97,296,695],"issues;":[98],"(11)":[99],"Specific":[100,511,662],"organ":[101,212,267,320,345,362],"management:":[102],"heart,":[103],"kidney,":[104],"liver,":[105],"lung":[106,444],"pancreas.":[108],"authors":[110,194,336,483],"confirm":[111],"impact":[114],"that":[115,133,196,249,256,338],"after":[117,164,607],"circulatory":[118],"determination":[119],"death":[121,156,665],"(DCD)":[122],"can":[123,137],"make":[124],"increase":[126,228],"availability":[128],"organs.":[130],"They":[131],"highlight":[132],"liver":[134],"lungs":[136],"be":[138,148,172,299,323,379,507,574,605,623,644],"used":[139],"from":[140,381,680],"selected":[141],"DCD":[142,152],"transplantation.":[145],"Clinicians":[146],"must":[147,298],"prepared":[149],"potential":[151,222,305,588,652],"scenarios":[153],"which":[155],"does":[157],"not":[158,308,378],"occur":[159],"within":[160],"established":[162],"time":[163,251],"withdrawal":[165],"life-sustaining":[167],"therapy:":[168],"appropriate":[169,190],"protocols":[170],"should":[171,204,263,322,377,506,573,604],"place":[174,597],"return":[176],"patient":[178],"a":[180,234,247,273,304,367,469,485,496,514,533,547,633],"critical":[181],"setting":[183],"continuing":[185],"provide":[189,205],"family":[191],"support.":[192],"comment":[195],"unit":[199],"caregivers":[200],"OPO":[202,257,330],"representatives":[203],"all":[206,270,421],"patients":[207,339,382],"equal":[209],"opportunities":[210],"donation.":[213],"One":[214],"recommendation":[216],"is":[217,446,474],"early":[219],"referral":[220],"procurement":[225,445,465],"agencies":[226],"period":[230],"available":[231],"evaluate":[233],"patient\u2019s":[235],"medical":[236,317],"suitability":[237,318],"relay":[242],"information":[243],"families":[245],"manner":[248],"minimizes":[250],"pressure.":[252],"group":[254],"recommends":[255],"or":[258,358,389,629,650],"designated":[259],"coordinators":[260],"expertise":[262],"authorization":[265],"institutions,":[271],"using":[272],"collaborative":[274],"approach":[275],"rest":[278],"healthcare":[281],"team.":[282],"There":[283],"are":[284,343,561,673,686],"several":[285],"recommendations":[286],"regarding":[287],"infections,":[290],"but":[291],"general,":[293],"risks":[294,302],"transmission":[297],"weighed":[300],"against":[301,355],"recipient":[306],"receiving":[309],"organ.":[311],"Determinations":[312],"about":[313],"an":[314,356],"individual":[315],"donor\u2019s":[316],"made":[324],"conjunction":[326],"local":[329],"involved":[332],"centers.":[334],"recommend":[337,484],"bacterial":[341],"meningitis":[342],"suitable":[344],"as":[347,349,563,615,630],"long":[348],"they":[350],"have":[351],"received":[352],"therapy":[353,501,636],"directed":[354],"identified":[357],"presumed":[359],"pathogen":[360],"while":[361],"recipients":[363],"get":[364],"treated":[365],"similar":[368],"antibiotic":[369],"regimen":[370],"5":[372],"10":[374,542],"days.":[375],"Organs":[376],"procured":[380],"undiagnosed":[384],"febrile":[385],"illnesses,":[386],"encephalitis,":[387],"meningitis,":[388],"flaccid":[390],"paralysis":[391],"unknown":[393],"etiology.":[394],"use":[396,427],"nucleic":[398],"acid":[399],"amplification":[400,430],"testing":[401,431],"detect":[403],"presence":[405],"virus":[409],"RNA":[410],"reduces":[411,586],"likelihood":[413],"unrecognized":[415],"viremia":[416],"by":[417],"approximately":[418],"half":[419],"high-risk":[422,435],"behavior":[423,436],"categories;":[424],"therefore,":[425],"nucleic-acid":[429],"was":[432],"recommended":[433,562],"groups.":[437],"A":[438],"frequent":[439],"challenge":[440],"kidney":[442],"conflicting":[447],"fluid":[448,455,471,504,566],"requirements":[449],"donor.":[452],"Traditionally,":[453],"aggressive":[454],"resuscitation":[456,505],"management":[458,671,696],"were":[459],"thought":[460,475],"result":[462],"improved":[464],"kidneys,":[467],"whereas":[468],"conservative":[470],"replacement":[472,500,572,626],"strategy":[473],"benefit":[477],"quality":[479],"lungs.":[481],"central":[486],"venous":[487],"catheter":[488,492],"and/or":[489],"pulmonary":[490],"artery":[491],"manage":[494],"fluids:":[495],"combination":[497,634],"CVP-targeted":[503],"gold":[509],"standard.":[510],"variables":[512],"include":[513],"mean":[515],"arterial":[516],"pressure":[517],"60":[519],"70":[521],"mm":[522],"Hg,":[523],"urinary":[524],"output":[525],"1":[527],"3":[529],"mL/kg":[530],"per":[531,544],"hour,":[532],"decrease":[534],"dose":[536],"vasoactive":[538],"agents":[539],"(dopamine":[540],"\u2264":[541],"\u03bcg/kg":[543],"minute),":[545],"left":[548,658],"ventricular":[549,659],"ejection":[550,660],"fraction":[551],"at":[553],"least":[554],"45%.":[555],"Isotonic":[556],"crystalloids":[557],"lactated":[559],"Ringer":[560],"first":[564],"line":[565],"management.":[567],"Dopamine":[568],"arginine":[570,639],"vasopressin":[571],"considered":[575,645],"when":[576],"hypotension":[577],"persists":[578],"despite":[579],"adequate":[580],"volume":[581],"resuscitation.":[582],"High-dose":[583],"corticosteroid":[584],"administration":[585],"deleterious":[589],"effects":[590],"inflammatory":[593],"cascade":[594],"set":[595],"subsequent":[598],"brain":[600],"death.":[601],"Ideally,":[602],"steroids":[603],"administered":[606],"blood":[608],"has":[609],"been":[610],"collected":[611],"tissue":[613],"typing":[614],"expression":[617],"leukocyte":[620],"antigen":[621],"may":[622],"suppressed.":[624],"Thyroid":[625],"therapy\u2014either":[627],"alone":[628],"part":[631],"intravenous":[638],"vasopressin,":[640],"corticosteroids,":[641],"insulin\u2014should":[643],"hemodynamically":[647],"unstable":[648],"cardiac":[653],"abnormal":[656],"(<45%)":[657],"fraction.":[661],"aspects":[663],"declaration":[666],"pediatric":[668],"donors,":[669],"including":[670],"goals":[672],"detailed":[674],"this":[676],"report":[677],"differ":[679],"adult":[681],"donors.":[682],"Furthermore,":[683],"organ-specific":[684],"considerations":[685],"discussed":[687],"great":[689],"detail\u2014an":[690],"extremely":[691],"helpful":[692],"tool":[693],"procurement.":[698]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}