{"id":"https://openalex.org/W2395545459","doi":null,"title":"The effect of aging on mucosal host defense.","display_name":"The effect of aging on mucosal host defense.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2395545459","mag":"2395545459","pmid":"https://pubmed.ncbi.nlm.nih.gov/14730364"},"language":"en","primary_location":{"id":"pmid:14730364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14730364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111841700","display_name":"Susanna Cunningham-Rundles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S Cunningham-Rundles","raw_affiliation_strings":["Immunology Research Laboratory, Department of Pediatrics, The New York Presbyterian Hospital-Cornell University Weill Medical College. 1300 York Avenue, New York, NY 10021, USA. scrundle@mail.med.cornell.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Research Laboratory, Department of Pediatrics, The New York Presbyterian Hospital-Cornell University Weill Medical College. 1300 York Avenue, New York, NY 10021, USA. scrundle@mail.med.cornell.edu","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111841700"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"],"apc_list":null,"apc_paid":null,"fwci":5.2198,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.94673512,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"20","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.13650000095367432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.875},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/subacute-infection","display_name":"subacute infection","score":0.5799999833106995},{"id":"https://openalex.org/keywords/gastrointestinal-immune-system","display_name":"gastrointestinal immune system","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8884046077728271},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6571113467216492},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6177040338516235},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6067551374435425},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5985232591629028},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.427334189414978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41866302490234375},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.41032496094703674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38102632761001587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09370386600494385},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009748","descriptor_name":"Nutrition Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14730364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14730364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},{"id":"mag:2395545459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14730364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066619342","https://openalex.org/W2006958725","https://openalex.org/W2075174082","https://openalex.org/W2002679217","https://openalex.org/W2065038959","https://openalex.org/W2015826427","https://openalex.org/W2892044775","https://openalex.org/W1990125277","https://openalex.org/W2006094712","https://openalex.org/W4310989402"],"abstract_inverted_index":{"Mucosal":[0],"immune":[1,23,49,71,86,112,121,142],"response":[2,24,122],"is":[3,28,54,76,89],"primed":[4],"at":[5,10],"birth":[6],"and":[7,64,139],"responses":[8],"generated":[9],"this":[11,99],"time":[12],"support":[13],"specific":[14,132],"immunity":[15,75],"in":[16,30,41,93,123],"later":[17],"life.":[18],"Conversely":[19],"development":[20],"of":[21,33,44,69,81,127,134],"mucosal":[22,74,120],"to":[25,108,130],"new":[26],"antigens":[27],"diminished":[29],"aging.":[31,124],"Availability":[32],"key":[34],"nutrients":[35],"that":[36,55,91],"are":[37,60],"conditionally":[38,56],"essential":[39,57],"especially":[40],"the":[42,66,79,84,94,110,140],"context":[43],"sub-acute":[45],"infections":[46],"may":[47],"limit":[48],"response.":[50],"A":[51],"critical":[52],"hypothesis":[53],"nutrient":[58],"requirements":[59],"associated":[61],"with":[62,83],"aging":[63,97],"form":[65],"fundamental":[67],"basis":[68],"observed":[70],"senescence.":[72],"Since":[73],"modulated":[77],"by":[78],"interaction":[80],"microflora":[82],"gut":[85,95],"system,":[87],"it":[88],"likely":[90],"changes":[92],"during":[96],"affect":[98],"microenvironment.":[100],"Probiotic":[101],"lactic":[102],"acid":[103],"bacteria":[104],"offer":[105],"one":[106],"approach":[107],"stimulating":[109],"gastrointestinal":[111],"system":[113],"thereby":[114],"enhancing":[115],"systemic":[116],"as":[117,119],"well":[118],"The":[125],"mechanisms":[126],"action":[128],"appear":[129],"include":[131],"stimulation":[133],"natural":[135],"killer":[136],"cells":[137],"(NK)":[138],"innate":[141],"system.":[143]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}