{"id":"https://openalex.org/W2395528275","doi":null,"title":"Effects of testosterone on the zona fasciculata of the male rat adrenal cortex. A correlated stereological and biochemical study.","display_name":"Effects of testosterone on the zona fasciculata of the male rat adrenal cortex. A correlated stereological and biochemical study.","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W2395528275","mag":"2395528275","pmid":"https://pubmed.ncbi.nlm.nih.gov/6317881"},"language":"en","primary_location":{"id":"pmid:6317881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6317881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of submicroscopic cytology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046529833","display_name":"Giuseppina Mazzocchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Mazzocchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113760650","display_name":"Malendowicz Lk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L K Malendowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018913222","display_name":"Claudia Robba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Robba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108198855","display_name":"Piera Rebuffat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Rebuffat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023479209","display_name":"Giuseppe Gottardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Gottardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039585400","display_name":"Virgilio Meneghelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Meneghelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112178478","display_name":"Nussdorfer Gg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G G Nussdorfer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9975,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76488032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"15","issue":"4","first_page":"991","last_page":"1005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adrenal-zona-fasciculata","display_name":"adrenal zona fasciculata","score":0.8429999947547913},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/5alpha-reductase","display_name":"5\u03b1-reductase","score":0.6539999842643738},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8989999890327454},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9160000085830688},{"id":"https://openalex.org/keywords/11beta-hydroxylase","display_name":"11\u03b2-hydroxylase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitochondrial-cristae","display_name":"mitochondrial cristae","score":0.7429999709129333},{"id":"https://openalex.org/keywords/smooth-endoplasmic-reticulum","display_name":"smooth endoplasmic reticulum","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nuclear-rna-synthesis","display_name":"nuclear RNA synthesis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/male-rats","display_name":"male rats","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8547255992889404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8528388738632202},{"id":"https://openalex.org/C2778736161","wikidata":"https://www.wikidata.org/wiki/Q3301573","display_name":"Zona fasciculata","level":3,"score":0.8349192142486572},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7672032117843628},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.7617957592010498},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.7113890051841736},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5437137484550476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.474319189786911},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.44970959424972534},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4457632601261139},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4351355731487274},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.41567137837409973},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38711094856262207},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2949609160423279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16587066650390625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12999334931373596}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015096","descriptor_name":"3-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6317881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6317881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of submicroscopic cytology","raw_type":"Journal Article"},{"id":"mag:2395528275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6317881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2425460496","https://openalex.org/W2472639852","https://openalex.org/W1993218037","https://openalex.org/W2410671165","https://openalex.org/W2413799876","https://openalex.org/W2017553792","https://openalex.org/W2089179957","https://openalex.org/W2089436881","https://openalex.org/W2146631051","https://openalex.org/W2406430548"],"abstract_inverted_index":{"The":[0,100],"effects":[1],"of":[2,10,30,45,66,83,87,103,110,121,130,135,141,144,160,167,175,189,200,212,216,225,239,245],"long-term":[3],"testosterone":[4,24,136,163,213,226],"administration":[5,134],"on":[6],"the":[7,31,40,43,46,58,61,76,79,104,118,128,142,145,157,165,170,183,186,190,198,201,207,233,236,243],"adrenal":[8,146,193],"cortex":[9],"male":[11,176,191],"rats":[12],"were":[13],"investigated":[14],"by":[15,75,197,232],"coupled":[16],"morphometric":[17],"and":[18,49,69,97,107,123,149,172,204,218],"biochemical":[19],"methods.":[20],"Morphometry":[21],"showed":[22],"that":[23,57,185,206],"treatment":[25],"provoked":[26,113,153],"a":[27,114,124,138,154],"time-dependent":[28],"atrophy":[29,188],"zona":[32],"fasciculata":[33],"cells,":[34],"which":[35],"was":[36,72],"mainly":[37],"due":[38,241],"to":[39,242,250],"decrease":[41,59,77],"in":[42,60,78,91,117,127,151,156,235],"volume":[44],"mitochondrial":[47,70,173,219],"compartment":[48],"smooth":[50],"endoplasmic":[51],"reticulum":[52],"(SER).":[53],"Biochemical":[54],"assays":[55],"demonstrated":[56],"surface":[62],"area":[63],"per":[64,81],"cell":[65,82],"SER":[67],"membranes":[68],"cristae":[71],"tightly":[73],"paralleled":[74],"activity":[80,143],"two":[84],"key":[85],"enzymes":[86],"steroid":[88],"synthesis":[89],"contained":[90],"them":[92],"(delta":[93],"5-3":[94],"beta-hydroxysteroid":[95],"dehydrogenase":[96],"11":[98],"beta-hydroxylase).":[99],"testosterone-induced":[101],"inhibition":[102,215,244],"growth":[105],"maintenance":[106],"steroidogenic":[108],"capacity":[109],"adrenocortical":[111,178],"cells":[112],"significant":[115],"fall":[116],"plasma":[119],"concentration":[120,159],"corticosterone":[122,240],"consequential":[125],"increase":[126],"level":[129],"circulating":[131],"ACTH.":[132],"Chronic":[133],"caused":[137],"notable":[139],"suppression":[140,199],"5":[147,246],"alpha-reductase":[148,247],"this":[150,210,223],"turn":[152],"rise":[155,234],"intracellular":[158,237],"corticosterone.":[161],"Moreover,":[162],"inhibited":[164],"incorporation":[166],"3H-uridine":[168],"into":[169],"nuclear":[171,217],"fractions":[174],"rat":[177,192],"cells.":[179],"These":[180],"findings":[181],"exclude":[182],"possibility":[184],"testosterone-provoked":[187],"glands":[194],"is":[195,227],"mediated":[196,231],"hypothalamo-hypophyseal":[202],"axis,":[203],"suggest":[205],"mechanism":[208],"underlying":[209],"action":[211],"involves":[214],"RNA":[220],"synthesis.":[221],"Whether":[222],"effect":[224],"directly":[228],"or":[229],"indirectly":[230],"content":[238],"activity,":[248],"remains":[249],"be":[251],"elucidated.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
