{"id":"https://openalex.org/W2395090862","doi":"https://doi.org/10.2340/0001555563447449","title":"Does long-term treatment with D-penicillamine alter calcium and phosphorus metabolism in patients with systemic sclerosis?","display_name":"Does long-term treatment with D-penicillamine alter calcium and phosphorus metabolism in patients with systemic sclerosis?","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W2395090862","doi":"https://doi.org/10.2340/0001555563447449","mag":"2395090862","pmid":"https://pubmed.ncbi.nlm.nih.gov/6197850"},"language":"en","primary_location":{"id":"doi:10.2340/0001555563447449","doi":"https://doi.org/10.2340/0001555563447449","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2340/0001555563447449","pdf_url":"https://medicaljournalssweden.se/actadv/article/download/8142/11618","source":{"id":"https://openalex.org/S4210210846","display_name":"Acta Dermato Venereologica","issn_l":"0001-5555","issn":["0001-5555","1651-2057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317100","host_organization_name":"Soc for Publication of\u00a0Acta Dermato-Venereologica","host_organization_lineage":["https://openalex.org/P4310317100"],"host_organization_lineage_names":["Soc for Publication of\u00a0Acta Dermato-Venereologica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Dermato-Venereologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://medicaljournalssweden.se/actadv/article/download/8142/11618","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111714705","display_name":"H Hagdrup","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Hagdrup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111745702","display_name":"J\u00f8rgen Vedelskov Serup","orcid":"https://orcid.org/0000-0003-3676-5198","observed_orcids":["https://orcid.org/0000-0003-3676-5198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Serup","raw_affiliation_strings":["Department of Dermatology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044189926","display_name":"Erling Tvedegaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"E. Tvedegaard","raw_affiliation_strings":["Medical Department P, University of Copenhal(en,","Department of Dermatology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department P, University of Copenhal(en,","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Dermatology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"EUR","value_usd":1725},"apc_paid":{"value":1600,"currency":"EUR","value_usd":1725},"fwci":0.8232,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75724977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"5","first_page":"447","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillamine","display_name":"D-penicillamine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcium-metabolism","display_name":"calcium metabolism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/phosphorus-metabolism","display_name":"phosphorus metabolism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mineral-balance","display_name":"mineral balance","score":0.6700000166893005},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9139999747276306},{"id":"https://openalex.org/keywords/urinary-calcium-excretion","display_name":"urinary calcium excretion","score":0.8299999833106995},{"id":"https://openalex.org/keywords/urinary-phosphorus-excretion","display_name":"urinary phosphorus excretion","score":0.972000002861023},{"id":"https://openalex.org/keywords/bone-mineral-content","display_name":"bone mineral content","score":0.968999981880188},{"id":"https://openalex.org/keywords/distal-radius","display_name":"distal radius","score":0.6769999861717224},{"id":"https://openalex.org/keywords/collagenase-inhibitors","display_name":"collagenase inhibitors","score":0.578000009059906},{"id":"https://openalex.org/keywords/hydralazine","display_name":"hydralazine","score":0.8209999799728394},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.800000011920929},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6803951859474182},{"id":"https://openalex.org/C2779348387","wikidata":"https://www.wikidata.org/wiki/Q421239","display_name":"Penicillamine","level":2,"score":0.6534575819969177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6147288084030151},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6114240884780884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5713273286819458},{"id":"https://openalex.org/C510538283","wikidata":"https://www.wikidata.org/wiki/Q674","display_name":"Phosphorus","level":2,"score":0.4858071804046631},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.43328046798706055},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4316597580909729},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4125329256057739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39196720719337463},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2340/0001555563447449","doi":"https://doi.org/10.2340/0001555563447449","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2340/0001555563447449","pdf_url":"https://medicaljournalssweden.se/actadv/article/download/8142/11618","source":{"id":"https://openalex.org/S4210210846","display_name":"Acta Dermato Venereologica","issn_l":"0001-5555","issn":["0001-5555","1651-2057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317100","host_organization_name":"Soc for Publication of\u00a0Acta Dermato-Venereologica","host_organization_lineage":["https://openalex.org/P4310317100"],"host_organization_lineage_names":["Soc for Publication of\u00a0Acta Dermato-Venereologica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Dermato-Venereologica","raw_type":"journal-article"},{"id":"pmid:6197850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6197850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta dermato-venereologica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2340/0001555563447449","doi":"https://doi.org/10.2340/0001555563447449","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2340/0001555563447449","pdf_url":"https://medicaljournalssweden.se/actadv/article/download/8142/11618","source":{"id":"https://openalex.org/S4210210846","display_name":"Acta Dermato Venereologica","issn_l":"0001-5555","issn":["0001-5555","1651-2057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317100","host_organization_name":"Soc for Publication of\u00a0Acta Dermato-Venereologica","host_organization_lineage":["https://openalex.org/P4310317100"],"host_organization_lineage_names":["Soc for Publication of\u00a0Acta Dermato-Venereologica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Dermato-Venereologica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2395090862.pdf","grobid_xml":"https://content.openalex.org/works/W2395090862.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1892921638","https://openalex.org/W2417938374","https://openalex.org/W2410065364","https://openalex.org/W4253383267","https://openalex.org/W2073685194","https://openalex.org/W1965044093","https://openalex.org/W1980250810","https://openalex.org/W2341164966","https://openalex.org/W2346591917","https://openalex.org/W2000079424"],"abstract_inverted_index":{"Only":[0],"animal":[1],"experiments":[2],"have":[3],"been":[4],"published":[5],"regarding":[6],"the":[7,55,64,82,92,105,119],"possible":[8],"effect":[9],"of":[10,23,58,71,81,91,112,134],"penicillamine":[11],"treatment":[12,141],"on":[13],"mineral":[14,79,124],"balance.":[15],"We":[16],"examined":[17],"35":[18],"patients":[19,33],"with":[20,27,31,34,38,142],"a":[21],"diagnosis":[22],"systemic":[24,35],"sclerosis":[25,36],"treated":[26,37],"penicillamine,":[28],"in":[29,52,118,128],"comparison":[30],"10":[32],"other":[39],"collagen":[40],"inhibitors":[41],"(glutamine,":[42],"hydralazine,":[43],"phenytoin,":[44],"chlorpromazine).":[45],"The":[46,67,77,122],"following":[47],"laboratory":[48],"tests":[49],"were":[50,75,102],"performed":[51,95],"all":[53],"patients:":[54],"serum":[56],"concentrations":[57],"calcium,":[59,61],"ionized":[60],"phosphorus":[62,74],"and":[63,73,114],"parathyroid":[65],"hormone.":[66],"24-hour":[68],"urinary":[69,110],"excretions":[70],"calcium":[72,113],"determined.":[76],"bone":[78,123],"content":[80,125],"distal":[83],"radius":[84],"was":[85,94,116,126,137],"determined":[86],"by":[87],"photon-absorptiometry;":[88],"radiological":[89],"examination":[90],"hands":[93],"to":[96,140],"show":[97],"aberrant":[98,135],"calcifications.":[99],"No":[100],"differences":[101],"found":[103,117],"between":[104],"two":[106],"groups.":[107,130],"A":[108,131],"low":[109,127],"excretion":[111],"phosphor":[115],"entire":[120],"material.":[121],"both":[129],"high":[132],"frequency":[133],"calcifications":[136],"not":[138],"correlated":[139],"penicillamine.":[143]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}