{"id":"https://openalex.org/W2395089185","doi":null,"title":"Adverse reactions in syphilis therapy.","display_name":"Adverse reactions in syphilis therapy.","publication_year":1976,"publication_date":"1976-12-01","ids":{"openalex":"https://openalex.org/W2395089185","mag":"2395089185","pmid":"https://pubmed.ncbi.nlm.nih.gov/1010785"},"language":"en","primary_location":{"id":"pmid:1010785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1010785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Venereal Disease Association","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059318789","display_name":"Brown St","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S T Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059318789"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.20996819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"3","issue":"2 Pt 2","first_page":"172","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syphilis","display_name":"syphilis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/jarisch-herxheimer-reaction","display_name":"Jarisch-Herxheimer reaction","score":0.9670000076293945},{"id":"https://openalex.org/keywords/therapeutic-paradox","display_name":"therapeutic paradox","score":0.9620000123977661},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9129999876022339},{"id":"https://openalex.org/keywords/treponemal-infection","display_name":"treponemal infection","score":0.6949999928474426},{"id":"https://openalex.org/keywords/neurosyphilis","display_name":"neurosyphilis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cranial-nerve-involvement","display_name":"cranial nerve involvement","score":0.8259999752044678},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.9449999928474426},{"id":"https://openalex.org/keywords/penicillin","display_name":"penicillin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8080000281333923},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/antibiotic-adverse-effects","display_name":"antibiotic adverse effects","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.8618379235267639},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7999618649482727},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.5801492929458618},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5154086351394653},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.4691639840602875},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.4295887351036072},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42926955223083496},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4279256761074066},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.42188718914985657},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36322635412216187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2648269236087799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18384161591529846},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.16868102550506592},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08968067169189453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007752","descriptor_name":"Obstetric Labor, Premature","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009494","descriptor_name":"Neurosyphilis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013587","descriptor_name":"Syphilis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013589","descriptor_name":"Syphilis, Cardiovascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013590","descriptor_name":"Syphilis, Congenital","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1010785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1010785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Venereal Disease Association","raw_type":"Journal Article"},{"id":"mag:2395089185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1010785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W176817522","https://openalex.org/W1563012850","https://openalex.org/W1971881221","https://openalex.org/W1979503340","https://openalex.org/W2019834218","https://openalex.org/W2053885058","https://openalex.org/W2060699853","https://openalex.org/W2066355803","https://openalex.org/W2075451324","https://openalex.org/W2079558403","https://openalex.org/W2104216921","https://openalex.org/W2120519294","https://openalex.org/W2123408425","https://openalex.org/W2133903115","https://openalex.org/W2409416477","https://openalex.org/W2415139106","https://openalex.org/W2415610547","https://openalex.org/W2465483110","https://openalex.org/W2469295877"],"related_works":["https://openalex.org/W2101785003","https://openalex.org/W1966563630","https://openalex.org/W2419069705","https://openalex.org/W3217676178","https://openalex.org/W2794419775","https://openalex.org/W2415335591","https://openalex.org/W2415872968","https://openalex.org/W2113566164","https://openalex.org/W4247874087","https://openalex.org/W2411962962"],"abstract_inverted_index":{"Reactions":[0],"related":[1,76],"to":[2,9,14,77,185,209],"treatment":[3],"of":[4,17,50,70,81,135,141,156,181,203],"syphilis":[5],"may":[6,95],"be":[7,96,159],"due":[8],"treponemal":[10,71,192],"infection,":[11,182],"therapy,":[12],"or":[13,118,133],"the":[15,24,29,78,139,154],"interaction":[16],"these.":[18],"In":[19,87],"this":[20,88],"review":[21],"I":[22,90],"discuss":[23],"Jarisch-Herxheimer":[25],"(J-H)":[26],"reaction":[27],"and":[28,66,106,166],"therapeutic":[30,85,195,198],"paradox.":[31],"Antibiotic":[32],"side":[33,53],"effects":[34],"are":[35,45,57,75,213],"not":[36,144,201],"unique":[37],"among":[38],"patients":[39],"treated":[40],"for":[41,48,147,167],"syphilis;":[42],"therefore,":[43],"readers":[44],"referred":[46],"elsewhere":[47],"reviews":[49],"major":[51],"antibiotic":[52],"effects.":[54],"J-H":[55,93],"reactions":[56,74,94,212],"acute,":[58],"transient":[59],"episodes":[60],"with":[61,116,129],"manifestations":[62],"occurring":[63],"both":[64],"systemically":[65],"at":[67],"local":[68,108],"sites":[69],"concentration.":[72],"These":[73],"rapid":[79,191],"destruction":[80,193],"treponemes":[82],"by":[83,104,194],"various":[84],"agents.":[86,196],"review,":[89],"suggest":[91],"that":[92],"significant":[97],"only":[98,161],"in":[99,127,131,150,162],"syphilitic":[100],"paresis,":[101],"pregnancy":[102],"complicated":[103],"syphilis,":[105],"when":[107],"inflammation":[109],"can":[110,158],"cause":[111],"serious":[112],"functional":[113],"compromise,":[114],"as":[115],"second":[117],"eighth":[119],"cranial":[120],"nerve":[121],"involvement.":[122],"Many":[123],"workers":[124],"use":[125,155],"prednisone":[126,157],"conjunction":[128],"penicillin":[130],"some":[132],"all":[134],"these":[136],"situations.":[137],"However,":[138],"efficacy":[140],"corticosteroids":[142],"has":[143],"been":[145],"evaluated":[146],"such":[148,211],"problems":[149],"clinical":[151,177],"trials.":[152],"Therefore,":[153],"supported":[160],"very":[163],"selected":[164],"situations":[165],"short":[168],"duration":[169],"(ie,":[170],"2":[171],"days).":[172],"Therapeutic":[173],"paradox,":[174],"which":[175],"is":[176,183],"worsening":[178],"despite":[179],"cure":[180],"said":[184],"result":[186],"from":[187],"scar":[188],"formation":[189],"after":[190],"The":[197],"paradox":[199],"does":[200],"appear":[202],"great":[204],"significance.":[205],"Futhermore,":[206],"no":[207],"methods":[208],"prevent":[210],"generally":[214],"advocated.":[215]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
