{"id":"https://openalex.org/W2395058374","doi":"https://doi.org/10.1152/ajplung.1995.269.2.l215","title":"Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells","display_name":"Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2395058374","doi":"https://doi.org/10.1152/ajplung.1995.269.2.l215","mag":"2395058374","pmid":"https://pubmed.ncbi.nlm.nih.gov/7653583"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.1995.269.2.l215","doi":"https://doi.org/10.1152/ajplung.1995.269.2.l215","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1995.269.2.l215","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020156437","display_name":"Boaz A. Markewitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. A. Markewitz","raw_affiliation_strings":["Department of Medicine, Veterans Affairs Medical Center, Salt LakeCity, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Veterans Affairs Medical Center, Salt LakeCity, Utah, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075086560","display_name":"Donald E. Kohan","orcid":"https://orcid.org/0000-0002-3981-2941","observed_orcids":["https://orcid.org/0000-0002-3981-2941"]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. E. Kohan","raw_affiliation_strings":["Department of Medicine, Veterans Affairs Medical Center, Salt LakeCity, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Veterans Affairs Medical Center, Salt LakeCity, Utah, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103838599","display_name":"J. R. Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210089864","display_name":"VA Salt Lake City Healthcare System","ror":"https://ror.org/007fyq698","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089864","https://openalex.org/I4210113540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. R. Michael","raw_affiliation_strings":["Department of Medicine, Veterans Affairs Medical Center, Salt LakeCity, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Veterans Affairs Medical Center, Salt LakeCity, Utah, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210089864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2947,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.79842536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"269","issue":"2","first_page":"L215","last_page":"L220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pulmonary-endothelial-cells","display_name":"pulmonary endothelial cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.890999972820282},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8600000143051147},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hypoxic-pulmonary-vasoconstriction","display_name":"hypoxic pulmonary vasoconstriction","score":0.6650000214576721},{"id":"https://openalex.org/keywords/vascular-tone-regulation","display_name":"vascular tone regulation","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7790540456771851},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.6879052519798279},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6061934232711792},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4943537712097168},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4817540645599365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48102933168411255},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.4775317907333374},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4610729515552521},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.427584171295166},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4184392988681793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39692986011505127},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37833863496780396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37204813957214355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33695805072784424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33436083793640137},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22753456234931946},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.15509635210037231},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13139712810516357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12157168984413147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10838916897773743},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019323","descriptor_name":"omega-N-Methylarginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.1995.269.2.l215","doi":"https://doi.org/10.1152/ajplung.1995.269.2.l215","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1995.269.2.l215","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:7653583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7653583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1025991121","display_name":"SCOR ON ACUTE LUNG INJURY","funder_award_id":"P50HL050153","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1407051737","display_name":null,"funder_award_id":"R29-DK-44440-01","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4029445860","display_name":"RENAL ENDOTHELIN-NEPHRON SYNTHESIS AND ACTIONS","funder_award_id":"R29DK044440","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5685733627","display_name":null,"funder_award_id":"5K04-HL-02297-04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5875202830","display_name":"REGULATION OF PULMONARY VASCULAR TONE","funder_award_id":"K04HL002297","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037447701","https://openalex.org/W2147620141","https://openalex.org/W2012574801","https://openalex.org/W2444379671","https://openalex.org/W2972611191","https://openalex.org/W2037268745","https://openalex.org/W2925195650","https://openalex.org/W2299845288","https://openalex.org/W2403888093","https://openalex.org/W2052819142"],"abstract_inverted_index":{"Endothelin-1":[0],"(ET-1)":[1],"is":[2,23,34,102],"a":[3,82,107,169,228],"21-amino":[4],"acid":[5],"peptide":[6],"synthesized":[7],"by":[8,64,91,212],"several":[9],"cell":[10],"types":[11],"in":[12,41,117,208],"the":[13,37,57,73,135,148,154,163,206,225],"lung.":[14],"Locally,":[15],"ET-1":[16,40,55,76,89,115,127,159,185,192,209],"regulates":[17],"vascular":[18,26],"and":[19,22,27,59,67,131,196,214],"airway":[20,28],"tone":[21],"mitogenic":[24],"for":[25,85],"smooth":[29],"muscle":[30],"cells.":[31,44,119],"Little,":[32],"however,":[33],"known":[35],"about":[36],"regulation":[38],"of":[39,54,61,75,79,100,106,121,138,142,156,218,227],"pulmonary":[42],"endothelial":[43,48],"Cultured":[45],"rat":[46],"lung":[47],"cells":[49],"(RLECs)":[50],"release":[51,193,210],"significant":[52],"amounts":[53],"into":[56],"supernatant,":[58],"isolation":[60],"RNA":[62],"followed":[63],"reverse":[65],"transcription":[66],"polymerase":[68],"chain":[69],"reaction":[70],"amplification":[71],"confirms":[72],"presence":[74],"mRNA.":[77],"Exposure":[78],"RLECs":[80,178],"to":[81,147,221],"hypoxic":[83,118,149],"environment":[84,150],"24":[86],"h":[87],"decreases":[88,184,191],"production":[90,190],"approximately":[92],"50%":[93],"compared":[94],"with":[95],"normoxic":[96,108],"controls.":[97],"The":[98,140],"effect":[99,137,155,217],"hypoxia":[101,132,157,182,219],"reversible":[103],"upon":[104],"restoration":[105],"environment.":[109],"RNase":[110],"protection":[111],"studies":[112],"reveal":[113],"decreased":[114],"mRNA":[116],"Inhibition":[120],"nitric":[122],"oxide":[123],"(NO)":[124],"synthase":[125],"increases":[126],"synthesis":[128,202],"during":[129,194],"normoxia":[130,195],"without":[133,224],"altering":[134],"inhibitory":[136],"hypoxia.":[139],"addition":[141],"10%":[143],"carbon":[144],"monoxide":[145],"(CO)":[146],"does":[151,166,203],"not":[152,167,204],"erase":[153],"on":[158],"production,":[160],"suggesting":[161],"that":[162,176],"transduction":[164],"process":[165],"involve":[168],"heme":[170,229],"sensor.":[171,230],"In":[172],"summary,":[173],"we":[174],"conclude":[175],"1)":[177],"synthesize":[179],"ET-1;":[180],"2)":[181],"reversibly":[183],"production;":[186],"3)":[187],"constitutive":[188,200],"NO":[189,201],"hypoxia;":[197,213],"4)":[198],"inhibiting":[199],"prevent":[205],"decrease":[207],"caused":[211],"5)":[215],"this":[216],"appears":[220],"be":[222],"transduced":[223],"involvement":[226]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}