{"id":"https://openalex.org/W2395050666","doi":"https://doi.org/10.1152/ajplegacy.1960.199.6.1121","title":"Effects of hypocapnia and hypercapnia on myocardial contractility","display_name":"Effects of hypocapnia and hypercapnia on myocardial contractility","publication_year":1960,"publication_date":"1960-12-01","ids":{"openalex":"https://openalex.org/W2395050666","doi":"https://doi.org/10.1152/ajplegacy.1960.199.6.1121","mag":"2395050666","pmid":"https://pubmed.ncbi.nlm.nih.gov/13772070"},"language":"en","primary_location":{"id":"doi:10.1152/ajplegacy.1960.199.6.1121","doi":"https://doi.org/10.1152/ajplegacy.1960.199.6.1121","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1960.199.6.1121","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113766361","display_name":"R. GRIER MONROE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Grier Monroe","raw_affiliation_strings":["Department of Physiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041679600","display_name":"Gordon N. French","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon French","raw_affiliation_strings":["Department of Physiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056666463","display_name":"James L. Whittenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Whittenberger","raw_affiliation_strings":["Department of Physiology, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":2.0476,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.85875352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"199","issue":"6","first_page":"1121","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.241799995303154,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.241799995303154,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.1688999980688095,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypocapnia","display_name":"hypocapnia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":1.0},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.9810000061988831},{"id":"https://openalex.org/keywords/stroke-work","display_name":"stroke work","score":0.8420000076293945},{"id":"https://openalex.org/keywords/carbon-dioxide-tension","display_name":"carbon dioxide tension","score":0.6690000295639038},{"id":"https://openalex.org/keywords/ventricular-function","display_name":"ventricular function","score":0.7990000247955322},{"id":"https://openalex.org/keywords/left-atrial-pressure","display_name":"left atrial pressure","score":0.8360000252723694},{"id":"https://openalex.org/keywords/rate-control","display_name":"rate control","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2778866228","wikidata":"https://www.wikidata.org/wiki/Q1328215","display_name":"Hypocapnia","level":4,"score":0.9586049914360046},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.8517651557922363},{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.6652916073799133},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6115172505378723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5461597442626953},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.46537917852401733},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.4346035420894623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41755327582359314},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4153309166431427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3498181104660034},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.32110416889190674},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.24215960502624512}],"mesh":[{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016857","descriptor_name":"Hypocapnia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplegacy.1960.199.6.1121","doi":"https://doi.org/10.1152/ajplegacy.1960.199.6.1121","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1960.199.6.1121","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},{"id":"pmid:13772070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13772070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2332458663","https://openalex.org/W2237534382","https://openalex.org/W1988744570","https://openalex.org/W2102296830","https://openalex.org/W2008235928","https://openalex.org/W2416797211","https://openalex.org/W4409138653","https://openalex.org/W108540343","https://openalex.org/W2079872504","https://openalex.org/W2413048131"],"abstract_inverted_index":{"Moderate":[0],"elevations":[1],"of":[2,37,52,62],"pCO2":[3,36,61],"(61\u201375":[4],"mm":[5,39,64],"Hg)":[6],"did":[7],"not":[8],"consistently":[9],"depress":[10],"myocardial":[11],"contractility":[12],"as":[13],"determined":[14],"by":[15,43,68],"standard":[16],"ventricular":[17],"function":[18],"curves.":[19],"With":[20],"an":[21,44,59],"altered":[22],"preparation":[23],"in":[24,47,72],"which":[25],"heart":[26],"rate":[27],"and":[28],"left":[29],"atrial":[30],"pressure":[31],"were":[32],"held":[33],"constant,":[34],"a":[35],"60\u201375":[38],"Hg":[40,65],"was":[41,66],"accompanied":[42],"average":[45],"reduction":[46,71],"stroke":[48,73],"work":[49],"to":[50],"73.6%":[51],"its":[53],"control":[54],"value,":[55],"while":[56],"hypocapnia":[57],"with":[58],"alveolar":[60],"6\u201313":[63],"unaccompanied":[67],"any":[69],"consistent":[70],"work.":[74]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
