{"id":"https://openalex.org/W2395048431","doi":null,"title":"Effect of probucol on blood cholesterol and basal and lovastatin-induced 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in mice.","display_name":"Effect of probucol on blood cholesterol and basal and lovastatin-induced 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in mice.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2395048431","mag":"2395048431","pmid":"https://pubmed.ncbi.nlm.nih.gov/2010669"},"language":"en","primary_location":{"id":"pmid:2010669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2010669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113902005","display_name":"Roger L. Gebhard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R L Gebhard","raw_affiliation_strings":["Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN 55417","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111605899","display_name":"William F. Prigge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W F Prigge","raw_affiliation_strings":["University of Minnesota\u2010Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota\u2010Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109226738","display_name":"J P Andreini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J P Andreini","raw_affiliation_strings":["University of Minnesota\u2010Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota\u2010Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041378628","display_name":"Martin L. Freeman","orcid":"https://orcid.org/0000-0003-3383-5269","observed_orcids":["https://orcid.org/0000-0003-3383-5269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Freeman","raw_affiliation_strings":["Medicine - Gastro, Hepatology, Nutrition Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine - Gastro, Hepatology, Nutrition Division","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5139,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8457194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"117","issue":"4","first_page":"299","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probucol","display_name":"probucol","score":1.0},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hepatic-cholesterol-metabolism","display_name":"hepatic cholesterol metabolism","score":0.6520000100135803},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.574999988079071},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.7229999899864197},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.42800000309944153},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2776167589","wikidata":"https://www.wikidata.org/wiki/Q10354103","display_name":"Probucol","level":3,"score":0.9921722412109375},{"id":"https://openalex.org/C2780940807","wikidata":"https://www.wikidata.org/wiki/Q417740","display_name":"Lovastatin","level":3,"score":0.8625166416168213},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.7608665823936462},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.7459346055984497},{"id":"https://openalex.org/C2777320049","wikidata":"https://www.wikidata.org/wiki/Q2989497","display_name":"Hydroxymethylglutaryl-CoA reductase","level":5,"score":0.6258854866027832},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.607334554195404},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.5979330539703369},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5883053541183472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5810075998306274},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5755971074104309},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4849993884563446},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.4105379581451416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39542415738105774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3070249557495117},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2973019778728485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2806629538536072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2762092649936676}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011341","descriptor_name":"Probucol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2010669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2010669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2395048431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2010669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2606327006","https://openalex.org/W2406156662","https://openalex.org/W2003731404","https://openalex.org/W2094400511","https://openalex.org/W2067375280","https://openalex.org/W2089889877","https://openalex.org/W1984661978","https://openalex.org/W651723767","https://openalex.org/W2039821372","https://openalex.org/W2055310601"],"abstract_inverted_index":{"The":[0,110],"drug":[1,33],"probucol":[2,25,100],"is":[3],"known":[4],"to":[5,12],"reduce":[6],"levels":[7],"of":[8,71,80,90,104],"blood":[9],"cholesterol":[10,58,106],"and":[11,57],"have":[13],"antioxidant":[14],"effects":[15,93],"on":[16],"lipoproteins":[17],"that":[18,31,76,99,115],"may":[19,120],"alter":[20],"their":[21],"metabolism.":[22],"While":[23],"studying":[24],"feeding":[26,79],"in":[27,86],"mice,":[28],"we":[29],"observed":[30],"the":[32,48,69,108,113],"lowered":[34],"total":[35],"hepatic,":[36],"but":[37],"not":[38,61],"gut,":[39],"3-hydroxyl-3-methylglutaryl":[40],"coenzyme":[41],"A":[42],"(HMG":[43],"CoA)":[44],"reductase":[45,74],"activities":[46],"during":[47],"diurnal":[49],"cycle.":[50],"Hepatic":[51],"fatty":[52],"acyl:cholesterol":[53],"acyl":[54],"transferase":[55],"activity":[56,75,83],"content":[59],"were":[60],"measurably":[62],"affected":[63],"by":[64,107],"probucol.":[65,128],"Probucol":[66],"also":[67],"abolished":[68],"induction":[70],"HMG":[72],"CoA":[73],"resulted":[77],"from":[78,122],"lovastatin,":[81],"when":[82],"was":[84],"measured":[85],"microsomes":[87],"washed":[88],"free":[89],"drugs.":[91],"These":[92],"are":[94],"consistent":[95],"with":[96,118,125],"previous":[97],"reports":[98],"increases":[101],"fractional":[102],"clearance":[103],"lipoprotein":[105],"liver.":[109],"findings":[111],"raise":[112],"possibility":[114],"some":[116],"patients":[117],"hypercholesterolemia":[119],"benefit":[121],"combined":[123],"therapy":[124],"lovastatin":[126],"plus":[127]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}