{"id":"https://openalex.org/W2395033756","doi":null,"title":"Inhibition of squamous cell carcinoma angiogenesis by direct interaction of retinoic acid with endothelial cells.","display_name":"Inhibition of squamous cell carcinoma angiogenesis by direct interaction of retinoic acid with endothelial cells.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W2395033756","mag":"2395033756","pmid":"https://pubmed.ncbi.nlm.nih.gov/8780165"},"language":"en","primary_location":{"id":"pmid:8780165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058226349","display_name":"Mark William Lingen","orcid":"https://orcid.org/0000-0001-9666-7608","observed_orcids":["https://orcid.org/0000-0001-9666-7608","https://orcid.org/0000-0001-9822-646X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Lingen","raw_affiliation_strings":["Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008563300","display_name":"Peter J. Polverini","orcid":"https://orcid.org/0000-0001-9832-967X","observed_orcids":["https://orcid.org/0000-0001-9832-967X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Polverini","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026371165","display_name":"No\u00ebl Bouck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N P Bouck","raw_affiliation_strings":["Northwestern University","University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9022,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.86725048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"74","issue":"2","first_page":"476","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8859999775886536},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8420000076293945},{"id":"https://openalex.org/keywords/corneal-neovascularization","display_name":"corneal neovascularization","score":0.8550000190734863},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.7300000190734863},{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"fibroblast growth factor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7739999890327454},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.7789999842643738},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7549448013305664},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6893384456634521},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5779643654823303},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5614644289016724},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5385706424713135},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5374084115028381},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.42356282472610474},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4104698598384857},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36397820711135864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36258119344711304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3583430051803589},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3520301580429077},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33457207679748535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3272237181663513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3261986970901489},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.29302918910980225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2762414813041687},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13980162143707275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12783324718475342},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8780165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2395033756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7896065299","display_name":"REGULATION OF MACROPHAGE ANGIOGENIC ACTIVITY","funder_award_id":"R01HL039926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8120167915","display_name":"SUPPRESSOR GENES, ONCOGENES AND ORAL CARCINOGENESIS                              ","funder_award_id":"K15DE000313","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G887976463","display_name":"TUMOR SUPPRESSOR GENES AND ANGIOGENESIS","funder_award_id":"R01CA052750","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W117293536","https://openalex.org/W2121176591","https://openalex.org/W2605235685","https://openalex.org/W2357217669","https://openalex.org/W160665775","https://openalex.org/W1995369328","https://openalex.org/W1519335206","https://openalex.org/W2086027965","https://openalex.org/W2085036524","https://openalex.org/W2112726396"],"abstract_inverted_index":{"Retinoic":[0],"acid":[1],"(RA)":[2],"is":[3,8,27],"a":[4,202,226,257],"multifunctional":[5],"drug":[6,60,138],"that":[7,39,58,211],"particularly":[9],"effective":[10],"at":[11],"preventing":[12],"the":[13,30,49,56,59,68,152,197,234,252],"development":[14],"of":[15,24,32,71,78,92,125,142,154,175,187,228,236,254],"multiple":[16],"primary":[17],"oral":[18,144,261],"squamous":[19,262],"cell":[20,263],"carcinomas.":[21],"A":[22],"portion":[23],"this":[25],"activity":[26,70],"due":[28],"to":[29,87,90,149,200,223,249,251],"inhibition":[31],"tumor":[33,42,50],"angiogenesis.":[34],"It":[35],"has":[36],"been":[37],"thought":[38],"RA":[40,79,117,167,177,212,255],"influences":[41],"angiogenesis":[43],"only":[44],"via":[45],"its":[46],"interactions":[47],"with":[48],"cells":[51,86,160,246],"themselves.":[52],"Here,":[53],"we":[54],"test":[55],"hypothesis":[57],"can":[61],"also":[62],"block":[63],"neovascularization":[64],"by":[65,95,184],"directly":[66,213],"inhibiting":[67,220],"angiogenic":[69,100,180],"normal":[72],"endothelial":[73,85,108,215],"cells.":[74],"Clinically":[75],"achievable":[76],"doses":[77],"rapidly":[80,217],"caused":[81],"large-":[82],"and":[83,114,132,156,178,218,232],"small-vessel":[84],"become":[88],"refractory":[89],"stimulation":[91],"migration":[93,126,141,153],"either":[94],"tumor-conditioned":[96,188],"media":[97,189],"or":[98],"purified":[99],"factors":[101],"(a-fibroblast":[102],"growth":[103],"factor":[104],"(aFGF),":[105],"bFGF,":[106],"vascular":[107,157,245],"GF,":[109,111],"platelet-derived":[110],"TGF":[112],"beta-1,":[113],"IL-8).":[115],"However,":[116],"had":[118],"little":[119],"effect":[120],"on":[121,244],"their":[122,179,191,206,221],"proliferation.":[123],"Inhibition":[124],"was":[127,133,146,161,182],"complete":[128],"within":[129],"3":[130],"hours":[131,136],"reversed":[134],"36":[135],"after":[137],"removal.":[139],"The":[140],"human":[143],"keratinocytes":[145],"not":[147],"sensitive":[148],"RA,":[150],"whereas":[151],"fibroblasts":[155],"smooth":[158],"muscle":[159],"inhibited.":[162],"To":[163],"determine":[164],"if":[165],"systemic":[166],"affected":[168],"neovascularization,":[169],"rats":[170,198],"were":[171],"given":[172],"1":[173],"mg/kg/day":[174],"all-trans":[176],"potential":[181],"tested":[183],"implanting":[185],"pellets":[186],"into":[190],"avascular":[192],"corneas.":[193,207],"This":[194],"treatment":[195],"rendered":[196],"unable":[199],"mount":[201],"neovascular":[203],"response":[204],"in":[205,230,239],"These":[208,241],"data":[209],"demonstrate":[210],"affects":[214],"cells,":[216],"reversibly":[219],"ability":[222],"migrate":[224],"toward":[225],"variety":[227],"stimuli":[229],"vitro":[231],"halting":[233],"formation":[235],"new":[237],"vessels":[238],"vivo.":[240],"direct":[242],"effects":[243],"seem":[247],"likely":[248],"contribute":[250],"success":[253],"as":[256],"chemopreventive":[258],"agent":[259],"for":[260],"carcinoma.":[264]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}