{"id":"https://openalex.org/W2394969253","doi":null,"title":"[Changes in GAT-3 and GABA-T mRNA expression of C6 glioma cells in response to a 2-week treatment with sodium valproate and withdrawal].","display_name":"[Changes in GAT-3 and GABA-T mRNA expression of C6 glioma cells in response to a 2-week treatment with sodium valproate and withdrawal].","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2394969253","mag":"2394969253","pmid":"https://pubmed.ncbi.nlm.nih.gov/13129709"},"language":"zh","primary_location":{"id":"pmid:13129709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13129709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101736213","display_name":"Yang Gao","orcid":"https://orcid.org/0000-0002-4966-0355","observed_orcids":["https://orcid.org/0000-0002-4966-0355"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Gao","raw_affiliation_strings":["Institute of Pharmaceutic Science, First Military Medical University, Guangzhou 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutic Science, First Military Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034662646","display_name":"Lin-sheng Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin-sheng Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101909556","display_name":"Shuguang Wu","orcid":"https://orcid.org/0000-0002-0700-4616","observed_orcids":["https://orcid.org/0000-0002-0700-4616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu-guang Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.17842544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"9","first_page":"885","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5922999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5922999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.20800000429153442,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.08250000327825546,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rebound-effect","display_name":"rebound effect","score":0.5709999799728394},{"id":"https://openalex.org/keywords/gat-3","display_name":"GAT-3","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gaba-transaminase","display_name":"GABA transaminase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chronic-drug-exposure","display_name":"chronic drug exposure","score":0.6940000057220459},{"id":"https://openalex.org/keywords/antiepileptic-drug-withdrawal","display_name":"antiepileptic drug withdrawal","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6013747453689575},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5893106460571289},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47818949818611145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45150434970855713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39782005548477173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3885996639728546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38504448533058167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3377029001712799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1358758509159088},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08381718397140503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06720221042633057}],"mesh":[{"descriptor_ui":"D000612","descriptor_name":"4-Aminobutyrate Transaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:13129709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13129709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA","raw_type":"English Abstract"},{"id":"mag:2394969253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13129709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W911392291","https://openalex.org/W2354768583","https://openalex.org/W2033658811","https://openalex.org/W2017582281","https://openalex.org/W2364667716","https://openalex.org/W1975276395","https://openalex.org/W2064631531","https://openalex.org/W2066238494","https://openalex.org/W2399808460","https://openalex.org/W2004800140"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"examine":[2,74],"the":[3,12,30,37,61,75,106,119,126,133,153,159,173,175,182],"effects":[4],"of":[5,14,32,40,64,77,135,152,161],"sodium":[6],"valproate(VPA)":[7],"treatment":[8,87,188],"and":[9,18,27,34,79,88,128,196,205],"withdrawal":[10,127,160,211],"on":[11],"expression":[13,82,98,114,143,178,195,200],"GABA":[15,19],"transporter-3":[16],"(GAT-3)":[17],"transaminase":[20],"(GABA-T)":[21],"mRNA":[22,81,97,113,142,167,177,194,199],"in":[23,36,52,83,105,164,201],"C6":[24,44,202],"glioma":[25,45,203],"cells,":[26,204],"to":[28,59,67,73,85,93,99,132,146,181],"explore":[29],"role":[31],"GAT-3":[33,78,96,112,193],"GABA-T":[35,80,141,166,176,198],"rebound":[38],"mechanism":[39],"VPA":[41,56,86,94,110,157,190,210],"withdrawal.":[42,89],"METHODS:":[43],"cells":[46],"were":[47],"maintained":[48],"for":[49],"2":[50],"weeks":[51],"DMEM":[53],"medium":[54],"containing":[55],"(50":[57],"mg/L)":[58],"establish":[60],"cell":[62],"model":[63],"chronic":[65],"exposure":[66,92],"VPA.":[68],"Semi-quantitative":[69],"RT-PCR":[70],"was":[71,144],"used":[72],"changes":[76],"response":[84],"RESULTS:":[90],"Chronic":[91,187],"down-regulated":[95],"39.1%":[100],"+/-0.5%":[101],"from":[102,149],"46%":[103],"+/-1.3%":[104],"control":[107,154],"group;":[108],"After":[109],"withdrawal,":[111,174],"level":[115,134,155,179],"kept":[116],"decreasing,":[117],"reaching":[118],"minimum":[120],"(11.7%":[121],"+/-1.6%)":[122],"24":[123,139],"h":[124,171],"after":[125,137,156,172],"with":[129,189],"an":[130],"increase":[131],"33.5%+/-1.1%":[136],"another":[138],"hr.":[140],"up-regulated":[145],"71.31%":[147],"+/-8.39%":[148],"34.77%":[150],"+/-2.36%":[151],"treatment,":[158],"which":[162],"resulted":[163],"decreased":[165,180],"expression.":[168],"Till":[169],"12":[170],"minimum,":[183],"25.36%":[184],"+/-7.68%.":[185],"CONCLUSIONS:":[186],"can":[191],"down-regulate":[192],"up-regulate":[197],"this":[206],"undulation":[207],"may":[208],"involve":[209],"rebound.":[212]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}